CASE REPORT OF SYNOVIAL SARCOMA PRESENTING AS A THIGH SWELLING

Authors

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i12.46084

Keywords:

Spindle cell,, Synovial sarcoma, thigh, immunohistochemistry

Abstract

Synovial sarcoma (SS) is a rare tumor arising from the mesenchymal lining and commonly arising near proximity of joint. The tumor is difficult to diagnose initially or can be misdiagnosed due to its site and slow-growing potential. This is a malignant tumor with genetic predisposition and has a poor prognosis, if metastasizes to distant organs. The current study tries to describe the clinical, histopathological and immunochemistry findings of synovial sarcoma. A case of SSs presented in our institute for surgery and histopathological examination. Relevant history was taken retrospectively and consent of the patient was also taken. The treatment modality consists of wide excision surgery, chemotherapy, and radiotherapy. In this case, a 35 years old having tumor growth involving thigh area, the excised tumor was sent to our department for histopathological examination. On HPE, monophasic spindle cell tumor was diagnosed with differential diagnosis of SS or malignant peripheral nerve sheath tumor and immunohistochemistry staining was done for further confirmation.

Downloads

Download data is not yet available.

Author Biography

NIDHI PRASAD, Department of Community Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.

Assistant Professor, Department of community medicine, IGIMS, Patna

References

Siegel HJ, Sessions W, Casillas MA Jr., Said-Al-Naief N, Lander PH, Lopez-Ben R. Synovial sarcoma: Clinicopathologic features, treatment, and prognosis. Orthopedics 2007;30:1020-5; quiz 1026-7. doi: 10.3928/01477447-20071201-15, PMID 18198773

Steinstraesser L, Agarwal R, Stricker I, Steinau HU, Al-Benna S. Biphasic synovial sarcoma of the extremity: Quadruple approach of isolated limb perfusion, surgical ablation, adipofascial perforator flap and radiation to avoid amputation. Case Rep Oncol 2011;4:222-8. doi: 10.1159/000327845, PMID 21516237

Sultan I, Rodriguez‐Galindo C, Saab R, Yasir S, Casanova M, Ferrari A. Comparing children and adults with synovial sarcoma in the surveillance, epidemiology, and end results program, 1983 to 2005: An analysis of 1268 patients. Cancer 2009;115:3537-47. doi: 10.1002/ cncr.24424, PMID 19514087

Correa H. Li-Fraumeni syndrome. J Pediatr Genet 2016;5:84-8. doi: 10.1055/s-0036-1579759. PMID 27617148, PMCID PMC4918696

Matthew R, Lindberg DL, Gardner JM, Cassarino DS, Stallings-Archer K. Diagnostic Pathology: Soft Tissue Tumors. Canada: Elsevier; 2016.

Rajwanshi A, Srinivas R, Upasana G. Malignant small round cell tumors. J Cytol 2009;26:1-10. doi: 10.4103/0970-9371.54861, PMID 21938141

Eilber FC, Dry SM. Diagnosis and management of synovial sarcoma. J Surg Oncol 2008;97:314-20. doi: 10.1002/jso.20974, PMID 18286474

Ruggiero A. Synovial sarcoma. Orphanet Encyclopedia March. 2004.

Mirzaian E, Tavangar SM, Montazeri S, Yeganeh FE. Biphasic epithelial predominant synovial sarcoma presenting as painful thigh mass. Iran J Pathol 2019;14:261-4. doi: 10.30699/ijp.2019.90673.1865, PMID 31583005

Wisanuyotin T, Radapat K, Sirichativapee W, Paholpak P, Kosuwon W, Sumnanoont C, et al. Prognostic factors and clinical outcomes in synovial sarcoma of the extremities. Asia Pac J Clin Oncol 2013;9:80-5. doi: 10.1111/j.1743-7563.2012.01563.x, PMID 22898085

Published

07-12-2022

How to Cite

KUMAR, B., and N. PRASAD. “CASE REPORT OF SYNOVIAL SARCOMA PRESENTING AS A THIGH SWELLING”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 12, Dec. 2022, pp. 6-8, doi:10.22159/ajpcr.2022.v15i12.46084.

Issue

Section

Case Study(s)