EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF DRACAENA TERNIFLORA ROXB. AGAINST ETHANOL INDUCED HEPATIC INJURY IN WISTAR ALBINO RATS
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i1.46287Keywords:
Hepatoprotective, Ethanol, Dracaena terniflora Roxb. Silymarin, In vivoAbstract
Objectives: The objectives of the study were to investigate hepatoprotective activity of ethanolic root extract of Dracaena terniflora Roxb. (DTR-E) in alcohol-induced hepatotoxicity in rats.
Methods: Hepatotoxicity was induced in albino Wistar rats by oral administration of 40% ethanol (2 mL/100 g body weight). DTR-E root extract was administered at a dose level of 100 mg/kg and 200 mg/kg orally for 21 days. On the 22nd day blood was taken by puncturing retro orbital plexus and used for the estimation of biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin, creatinine, urea, triglycerides, total cholesterol, albumin, and total protein. Animals were sacrificed by cervical dislocation and liver was dissected out and histopathological analysis of liver and kidney was carried out.
Results: Obtained results revealed that administration of ethanol caused a significant increase in liver weight, plasma ALT, AST, ALP, bilirubin creatinine, urea, triglycerides,and total cholesterol compared to the control group, while total protein and albumin concentration are significantly declined which were effectively prevented by the DTR-E extract. The histopathological observations supported the biochemical evidence of hepatoprotection.
Conclusions: The findings suggest that DTR-E root extract protects the liver cell from ethanol induced liver damages due to its antioxidative effect on hepatocytes. The results of the present investigation indicated that roots of D. terniflora Roxb. possesses significant hepatoprotective activity.
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