INCIDENCE AND RISK FACTORS FOR DRY EYE DISEASE IN A TERTIARY HOSPITAL IN NORTH CENTRAL INDIA
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i2.46517Keywords:
Dry Eye Disease, Dry Eye, Ocular surface, Tear Film, Contact LensAbstract
Objectives: Dry eye disease (DED is a severe tear insufficiency condition that affects millions of people worldwide. Dry eye refers to conditions of the tear film brought on by decreased tear production and/or excessive tear evaporation. The study’s objective was to compile data on the incidence of DED and associated risk factors.
Methods: The government hospital of Uttar Pradesh (India) served as the study’s site for this cross-sectional and observational study. Clinical observation and the ocular surface disease index survey were used to assess the aim of the study.
Results: Patients were screened in total, 652. The incidence of DED was reported in 267 (40.9%) individuals. There were 130 DED patients (48.7%) above the age of 40, followed by those between the ages of 21 and 40 (47.2%). Both genders were equally impacted, with men (50.2%) and women (49.2%). Out of 267 DED patients, 128 (47.9%) had a desk job with a computer. Among the patients, 57 (21.3%) had mild DED, 74 (27.7%) had moderate DED, and 136 (50.9%) had severe DED. The severe DED also showed independent association between the desk job with a computer (Odds Ratio [OR]; 2.782, 95% confidence interval [CI]: 1.694–4.568, p<0.001), cigarette smoking (OR; 1.849, 95% CI: 1.135–3.014, p=0.014), and use of contact lens (OR; 1.972, 95% CI: 1.206–3.223, p=0.007).
Conclusion: The frequency of DED is high in Uttar Pradesh. The illness is particularly prevalent in older people, computer-using desk workers, smokers, and contact lens wearers.
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References
Miljanović B, Dana R, Sullivan DA, Schaumberg DA. Impact of dry eye syndrome on vision-related quality of life. Am J Ophthalmol 2007;143:409-15. doi: 10.1016/j.ajo.2006.11.060, PMID 17317388
Nichols KK, Mitchell GL, Zadnik K. The repeatability of clinical measurements of dry eye. Cornea 2004;23:272-85. doi: 10.1097/00003226-200404000-00010, PMID 15084861
Begley CG, Caffery B, Nichols KK, Chalmers R. Responses of contact lens wearers to a dry eye survey. Optom Vis Sci 2000;77:40-6. doi: 10.1097/00006324-200001000-00012, PMID 10654857
Kallarackal GU, Ansari EA, Amos N, Martin JC, Lane C, Camilleri JP. A comparative study to assess the clinical use of fluorescein meniscus time (FMT) with tear break up time (TBUT) and Schirmer’s tests (ST) in the diagnosis of dry eyes. Eye (Lond) 2002;16:594-600. doi: 10.1038/ sj.eye.6700177, PMID 12194075
Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL. Reliability and validity of the ocular surface disease index. Arch Ophthalmol 2000;118:615-21. doi: 10.1001/archopht.118.5.615, PMID 10815152
Bakkar MM, Shihadeh WA, Haddad MF, Khader YS. Epidemiology of symptoms of dry eye disease (DED) in Jordan: A cross-sectional non-clinical population-based study. Cont Lens Anterior Eye 2016;39:197-202. doi: 10.1016/j.clae.2016.01.003, PMID 26833214
Hashemi H, Khabazkhoob M, Kheirkhah A, Emamian MH, Mehravaran S, Shariati M, et al. Prevalence of dry eye syndrome in an adult population. Clin Exp Ophthalmol 2014;42:242-8. doi: 10.1111/ ceo.12183, PMID 23927383
Lee AJ, Lee J, Saw SM, Gazzard G, Koh D, Widjaja D, et al. Prevalence and risk factors associated with dry eye symptoms: A population based study in Indonesia. Br J Ophthalmol 2002;86:1347-51. doi: 10.1136/ bjo.86.12.1347, PMID 12446361
Moss SE, Klein R, Klein BE. Prevalence of and risk factors for dry eye syndrome. Arch Ophthalmol 2000;118:1264-8. doi: 10.1001/archopht.118.9.1264, PMID 10980773
Onwubiko SN, Eze BI, Udeh NN, Arinze OC, Onwasigwe EN, Umeh RE. Dry eye disease: Prevalence, distribution and determinants in a hospital-based population. Cont Lens Anterior Eye 2014;37:157-61. doi: 10.1016/j.clae.2013.09.009, PMID 24126152
Sendecka M, Baryluk A, Polz-Dacewicz M. Prevalence and risk factors of dry eye syndrome. Przegl Epidemiol 2004;58:227-33. PMID 15218664
Tan LL, Morgan P, Cai ZQ, Straughan RA. Prevalence of and risk factors for symptomatic dry eye disease in Singapore. Clin Exp Optom 2015;98:45-53. doi: 10.1111/cxo.12210, PMID 25269444
Uchino M, Nishiwaki Y, Michikawa T, Shirakawa K, Kuwahara E, Yamada M, et al. Prevalence and risk factors of dry eye disease in Japan: Koumi study. Ophthalmology 2011;118:2361-7. doi: 10.1016/j. ophtha.2011.05.029, PMID 21889799
Vehof J, Kozareva D, Hysi PG, Hammond CJ. Prevalence and risk factors of dry eye disease in a British female cohort. Br J Ophthalmol 2014;98:1712-7. doi: 10.1136/bjophthalmol-2014-305201, PMID 25185440
Zhang Y, Chen H, Wu X. Prevalence and risk factors associated with dry eye syndrome among senior high school students in a county of Shandong Province, China. Ophthal Epidemiol 2012;19:226-30. doi: 10.3109/09286586.2012.670742, PMID 22650150
Gupta SK, Gupta V, Joshi S, Tandon R. Subclinically dry eyes in urban Delhi: An impact of air pollution? Ophthalmologica 2002;216:368-71. doi: 10.1159/000066183, PMID 12424406
Gupta N, Prasad I, Jain R, D’Souza P. Estimating the prevalence of dry eye among Indian patients attending a tertiary ophthalmology clinic. Ann Trop Med Parasitol 2010;104:247-55. doi: 10.1179/136485910X1 2647085215859, PMID 20507698
Basak SK, Pal PP, Basak S, Bandyopadhyay A, Choudhury S, Sar S. Prevalence of dry eye diseases in hospital-based population in West Bengal, Eastern India. J Indian Med Assoc 2012;110:789-94. PMID 23785913
Sahai A, Malik P. Dry eye: Prevalence and attributable risk factors in a hospital-based population. Indian J Ophthalmol 2005;53:87-91. doi: 10.4103/0301-4738.16170, PMID 15976462
Shilpy N, Patel DB. Prevalence of dry eye disease in Western India. Int J Contemp Med Res 2019;6:G10-2. doi: 10.21276/ijcmr.2019.6.7.37
Shah S, Jani H. Prevalence and associated factors of dry eye: Our experience in patients above 40 years of age at a tertiary care center. Oman J Ophthalmol 2015;8:151-6. doi: 10.4103/0974-620X.169910, PMID 26903719
Rege A, Kulkarni V, Puthran N, Khandgave T. A clinical study of subtype-based prevalence of dry eye. J Clin Diagn Res 2013;7:2207-10. doi: 10.7860/JCDR/2013/6089.3472, PMID 24298477
Guillemin I, Begley C, Chalmers R, Baudouin C, Arnould B. Appraisal of patient-reported outcome instruments available for randomized clinical trials in dry eye: Revisiting the standards. Ocul Surf 2012;10:84-99. doi: 10.1016/j.jtos.2012.01.007, PMID 22482469
Abetz L, Rajagopalan K, Mertzanis P, Begley C, Barnes R, Chalmers R,et al. Development and validation of the impact of dry eye on everyday life (IDEEL) questionnaire, a patient-reported outcomes (PRO) measure for the assessment of the burden of dry eye on patients. Health Qual Life Outcomes 2011;9:111. doi: 10.1186/1477-7525-9-111, PMID 22152125
US Department of Health and Human Services. FDA Center for Drug Evaluation and Research. Department of Health and Human Services FDA Center for Devices and Radiological Health. Guidance for industry: Patient-reported outcome measures: Use in medical product development to support labeling claims: Draft guidance. Health Qual Life Outcomes 2006;4:79.
Grubbs JR Jr., Tolleson-Rinehart S, Huynh K, Davis RM. A review of quality of life measures in dry eye questionnaires. Cornea 2014;33:215-8. doi: 10.1097/ICO.0000000000000038, PMID 24326332
Goud R, Aggarwal M, Radhakrishnan OK, Mantri P, Shah A. Prevalence of dry eyes in patients with Type-2 diabetes mellitus. Indian J Clin Exp Ophthalmol 2020;6:286-90. doi: 10.18231/j.ijceo.2020.062
Titiyal JS, Falera RC, Kaur M, Sharma V, Sharma N. Prevalence and risk factors of dry eye disease in North India: Ocular surface disease index-based cross-sectional hospital study. Indian J Ophthalmol 2018;66:207-11. doi: 10.4103/ijo.IJO_698_17, PMID 29380759
Bron AJ, Tiffany JM. The contribution of Meibomian disease to dry eye. Ocul Surf 2004;2:149-65. doi: 10.1016/s1542-0124(12)70150-7, PMID 17216085
Versura P, Cellini M, Torreggiani A, Profazio V, Bernabini B, Caramazza R. Dryness symptoms, diagnostic protocol and therapeutic management: A report on 1,200 patients. Ophthalmic Res 2001;33:221-7. doi: 10.1159/000055674, PMID 11464075
Attri S, Dwivedi J, Mithal S, Gupta A, Singh LK. Dry eye study of prevalence, associated risk factors and frequency of symptoms in Meerut District. J Evol Med Dent Sci 2019;8:3382-6. doi: 10.14260/ jemds/2019/734
Chlasta-Twardzik E, Górecka-Nitoń A, Nowińska A, Wylęgała E. The influence of work environment factors on the OcularSurface in a one-year follow-up prospective clinical study. Diagnostics (Basel) 2021;11:392. doi: 10.3390/diagnostics11030392, PMID 33668951
Uchino M, Yokoi N, Uchino Y, Dogru M, Kawashima M, Komuro A, et al. Prevalence of dry eye disease and its risk factors in visual display terminal users: The Osaka study. Am J Ophthalmol 2013;156:759-66. doi: 10.1016/j.ajo.2013.05.040, PMID 23891330
Reshma BK, Iram S. Prevalence of dry eye in computer users. IP Int J Ocul Oncol Oculoplasty 2020;6:95-8.
Doughty MJ, Fonn D, Richter D, Simpson T, Caffery B, Gordon K. A patient questionnaire approach to estimating the prevalence of dry eye symptoms in patients presenting to optometric practices across Canada. Optom Vis Sci 1997;74:624-31. doi: 10.1097/00006324- 199708000-00023, PMID 9323733
Xu L, Zhang W, Zhu XY, Suo T, Fan XQ, Fu Y. Smoking and the risk of dry eye: A meta-analysis. Int J Ophthalmol 2016;9:1480-6. doi: 10.18240/ijo.2016.10.19, PMID 27803868
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