CLINICAL PROFILE AND SPIROMETRIC FINDINGS IN PATIENTS HAVING OBSTRUCTIVE SLEEP APNOEA: A PROSPECTIVE STUDY
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i2.46628Keywords:
Obstructive Sleep Apnea, Snoring, Sleep Disturbance, SpirometryAbstract
Objectives: The objectives of the study are as follows: (1) To study the clinical profile of patients with OSA. (2) To assess the prevalence of spirometric abnormalities in obstructive sleep apnea (OSA).
Methods: This was a prospective study in which 50 patients with OSA were included on the basis of a predefined inclusion and exclusion criteria. Written informed consent was obtained from the participants. Demographic data such as age, gender, weight, height, and BMI were recorded. Severity of OSA was diagnosed on the basis of Apnea-Hypoapnea index. Presenting complaints were analyzed. Spirometry was done in all the cases and disease pattern such as obstructive or restrictive was determined. SSPS 21.0 software was used for statistical analysis and p<0.05 was taken as statistically significant.
Results: Among the 50 studied cases, there were 36 (72 %) males and 14 (28.00%) females with a M: F ratio of 1: 0.38. The mean age of the studied cases was found to be 50.04±13.58 years. majority of the patients presenting with obstructive sleep apnea were either obese (64.00%) or overweight (26.00%). OSA was found to be mild, moderate, and severe in 27 (54.00 %), 18 (36.00%), and 5 (10.00 %) patients, respectively. snoring (100%) followed by disturbed sleep or difficulty falling asleep 32 (64%) were most common presenting complaints. Overall abnormal spirometry findings were seen in 35 (70%) patients.
Conclusion: Snoring and sleep disturbance are the common presenting complaints in patients with OSA. A significant number of patients with OSA are found to have spirometric abnormalities.
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Jehan S, Auguste E, Pandi-Perumal SR, Kalinowski J, Myers AK, Zizi F, et al. Depression, obstructive sleep apnea and psychosocial health. Sleep Med Disord 2017;1:00012. PMID 29517078, PMCID PMC5836734
Bernstein P, Ebba JH. Snoring versus obstructive sleep apnea: A case report. Perm J 2006;10:21-3. doi: 10.7812/TPP/05-116, PMID 21519450, PMCID PMC3076978
Spicuzza L, Caruso D, Di Maria G. Obstructive sleep apnoea syndrome and its management. Ther Adv Chronic Dis 2015;6:273-85. doi: 10.1177/2040622315590318, PMID 26336596, PMCID PMC4549693
Luyster FS, Buysse DJ, Strollo PJ Jr. Comorbid insomnia and obstructive sleep apnea: Challenges for clinical practice and research. J Clin Sleep Med 2010;6:196-204. doi: 10.5664/jcsm.27772, PMID 20411700, PMCID PMC2854710
Rezaeitalab F, Moharrari F, Saberi S, Asadpour H, Rezaeetalab F. The correlation of anxiety and depression with obstructive sleep apnea syndrome. J Res Med Sci 2014;19:205-10. PMID 24949026, PMCID PMC4061640
Adler D, Bailly S, Benmerad M, Joyeux-Faure M, Jullian-Desayes I, Soccal PM, et al. Clinical presentation and comorbidities of obstructive sleep apnea-COPD overlap syndrome. PLoS One 2020;15:e0235331. doi: 10.1371/journal.pone.0235331, PMID 32645005
Donovan LM, Boeder S, Malhotra A, Patel SR. New developments in the use of positive airway pressure for obstructive sleep apnea. J Thorac Dis 2015;7:1323-42. doi: 10.3978/j.issn.2072-1439.2015.07.30, PMID 26380760
Yawn BP, Mintz ML, Doherty DE. Gold in practice: Chronic obstructive pulmonary disease treatment and management in the primary care setting. Int J Chron Obstruct Pulm Dis 2021;16:289-99. doi: 10.2147/ COPD.S222664, PMID 33603355, PMCID PMC7886101
Sharma SK, Kumpawat S, Banga A, Goel A. Prevalence and risk factors of obstructive sleep apnea syndrome in a population of Delhi, India. Chest 2006;130:149-56. doi: 10.1378/chest.130.1.149, PMID 16840395
Young T, Shahar E, Nieto FJ, Redline S, Newman AB, Gottlieb DJ, et al. Predictors of sleep-disordered breathing in community-dwelling adults: The Sleep Heart Health Study. Arch Intern Med 2002;162:893-900. doi: 10.1001/archinte.162.8.893, PMID 11966340
Ip MS, Lam B, Lauder IJ, Tsang KW, Chung KF, Mok YW, et al. A community study of sleep-disordered breathing in middle-aged Chinese men in Hong Kong. Chest 2001;119:62-9. doi: 10.1378/ chest.119.1.62, PMID 11157585
Kiral N, Salepçi B, Fidan A. Relationship between obstructive sleep apnea syndrome severity and age. Eur Respir J 2011;38:2190.
Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med 2005;172:1447-51. doi: 10.1164/rccm.200505-702OC. PMID 16141444, PMCID PMC2718439
Alchanatis M, Zias N, Deligiorgis N, Liappas I, Chroneou A, Soldatos C, et al. Comparison of cognitive performance among different age groups in patients with obstructive sleep apnea. Sleep Breath 2008;12:17-24. doi: 10.1007/s11325-007-0133-y, PMID 17906886
Peppard PE, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA 2000;284:3015-21. doi: 10.1001/jama.284.23.3015, PMID 11122588
Bielicki P, Trojnar A, Sobieraj P, Wąsik M. Smoking status in relation to obstructive sleep apnea severity (OSA) and cardiovascular comorbidity in patients with newly diagnosed OSA. Adv Respir Med 2019;87:103-9. doi: 10.5603/ARM.a2019.0011, PMID 31038721
Potdukhe K, Viswakarma R, Patel K, Darji D. Study outcome of continuous positive airway pressure in obstructive sleep apnea. MedPulse Int J ENT 2019;11:50-3. doi: 10.26611/10161131
Stansbury RC, Strollo PJ. Clinical manifestations of sleep apnea. J Thorac Dis 2015;7:E298-310. doi: 10.3978/j.issn.2072- 1439.2015.09.13, PMID 26543619, PMCID PMC4598518
Mehfooz N, Siraj F, Shabir A, Mantoo S, Shah TH, Hafiz U, et al. Spirometric abnormalities in patients with sleep-related breathing disorders. J Family Med Prim Care 2021;10:1009-14. doi: 10.4103/ jfmpc.jfmpc_1018_20. PMID 34041113, PMCID PMC8138423
Thorve SM, Gupta V, Mandilwar S, Modi N, Prabhudesai P. Spirometry and flow volume loops in obstructive sleep apnea patients. Int J Contemp Med Res 2019;6:L5-10. doi: 10.21276/ijcmr.2019.6.12.25
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