ANALYZING THE CHANGES IN THYROID HORMONES AND THE SERUM LIPID PROFILE IN NON-PREGNANT, PREGNANT, AND PREECLAMPTIC WOMEN

Authors

  • KAVITA TANWAR Department of Obstetrics and Gynaecology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.
  • PREETI MALHOTRA Department of Obstetrics and Gynaecology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.
  • HEMENDRA YADAV Department of , Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.
  • SUMAN JAIN Department of Biochemistry, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i1.46663

Keywords:

Thyroid profile, Lipid profile, Pre-eclampsia, Pregnant women, Triiodothyronine, Thyroxine, Thyrotropin-stimulating hormone

Abstract

Objective: The objective of the study was to investigate lipids and thyroid profile status among women with (100 pregnant women) or without pregnancy (100 normal) and with preeclampsia (100 pre-eclamptic women).

Methods: The Department of Obstetrics and Gynecology at the Pacific Institute of Medical Sciences in Udaipur treated 300 patients (obstetric cases) for the current case control comparative study. The total lipid and thyroid profile were examined for in a fasting blood sample.

Results: The study showed increased level of triiodothyronine, thyroxine in pre-eclampsia than normal pregnant but non-significant. Lipid profile (TC, TG, LDL, and VLDL), TSH were significantly higher in pre-eclampsia than in normal pregnant and non- pregnant women.

Conclusion: Thyroid disorder is one of the predisposing causes for pre-eclampsia. Hence, thyroid hormonal assay can be considered as a screening test for early diagnosis and treatment of pre-eclampsia to prevent further complications of it.

Downloads

Download data is not yet available.

Author Biographies

KAVITA TANWAR, Department of Obstetrics and Gynaecology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.

Assistant Professor, Department of Obstetrics and Gynaecology,

 Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.

 

PREETI MALHOTRA, Department of Obstetrics and Gynaecology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.

Assistant Professor, Department of Obstetrics and Gynaecology,

 Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India

HEMENDRA YADAV, Department of , Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.

Intensivist, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.

 

SUMAN JAIN, Department of Biochemistry, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.

Associate professor, Department of Biochemistry,

 Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.

 

References

Bellamy L, Casas JP, Hingorani AD, Williams DJ. Pre-eclampsia and risk of cardiovascular disease cancer in later life: Systematic review and meta-analysis. BMJ 2007;335:974. doi: 10.1136/bmj.39335.385301.BE

Solomon CG, Seely EW. Brief review: Hypertension in pregnancy: A manifestation of the insulin resistance syndrom? Hypertension 2001;37:232-9. doi: 10.1161/01.hyp.37.2.232, PMID 11230277

Qublan HS, Al-Kaisi IJ, Hindawi IM, Hiasat MS, Awamleh I, Hamaideh AH, et al. Severe pre-eclampsia and maternal thyroid function. J Obstet Gynaecol 2003;23:244-6. doi: 10.1080/0144361031000098334, PMID 12850851

Kaya E, Şahin Y, Özkeçeci Z, Paçaoglu H. Relation between birth weight and thyroid function in preelampsia-eclampsia. Gynecol Obstet Investig 1994;37:30-3. doi: 10.1159/000292516

Kumar A, Ghosh BK, Murthy NS. Maternal thyroid hormonal status in preeclampsia. Indian J Med Sci 2005;59:57-63. doi: 10.4103/0019- 5359.13904, PMID 15738611

Llurba E, Gratacos E, Martín-Gallan P, Cabero L, Dominguez C. A comprehensive study of oxidative stress and antioxidant status in preeclampsia and normal pregnancy. Free Radic Biol Med 2004;37:557-70.

De J, Mukhopadhyay A, Saha PK. Study of serum lipid profile in pregnancy induced hypertension. Indian J Clin Biochem 2006;21:165-8. doi: 10.1007/BF02912935, PMID 23105637

Adegoke OA, Iyare EE, Gbenebitse SO. Fasting plasma glucose and cholesterol levels in pregnant Nigerian women. Niger Postgrad Med J 2003;10:32-6. PMID 12717462

Gratacós E. Lipid-mediated endothelial dysfunction: A common factor to preeclampsia and chronic vascular disease. Eur J Obstet Gynecol Reprod Biol 2000;92:63-6. doi: 10.1016/s0301-2115(00)00427-9, PMID 10986436

Mohanty S, Nayak N, Nanda NN, Rao P. Serum lipids and malondialdehyde levels in primiparous patients with pregnancy induced hypertension. Indian J Clin Biochem 2006;21:189-92. doi: 10.1007/ BF02913094, PMID 23105597

Pottecher J, Huet O, Degos V, Bonnet MP, Gaussem P, Duranteau J, et al. In vitro plasma-induced endothelial oxidative stress and circulating markers of endothelial dysfunction in preeclampsia: An observational study. Hypertens Pregnancy 2009;28:212-23. doi: 10.1080/10641950802601195, PMID 19437231

Rahman MH, Chowdhury MA, Alam MT. Serum thyroxine and triiodothyronine levels in normal pregnancy and pre-eclampsia. J Teach Assoc 2007;20:6-10. doi: 10.3329/taj.v20i1.3082

Bañkowska EM, Pawłowska A, Leibschang J. Thyroid function in pregnant women with pregnancy induced hypertension. Ginekol Pol 2003;74:1044-8. PMID 14669392

Larijani B, Marsoosi V, Aghakhani S, Moradi A, Hashemipour S. Thyroid hormone alteration in pre-eclamptic women. Gynecol Endocrinol 2004;18:97-100. doi: 10.1080/09513590310001652973, PMID 15195501

Published

07-01-2022

How to Cite

TANWAR, K., P. MALHOTRA, H. YADAV, and S. JAIN. “ANALYZING THE CHANGES IN THYROID HORMONES AND THE SERUM LIPID PROFILE IN NON-PREGNANT, PREGNANT, AND PREECLAMPTIC WOMEN”. Asian Journal of Pharmaceutical and Clinical Research, vol. 16, no. 1, Jan. 2022, pp. 134-6, doi:10.22159/ajpcr.2023.v16i1.46663.

Issue

Section

Original Article(s)