PHYSICOCHEMICAL, FORMULATION, AND EVALUATION OF ANTIFUNGAL HERBAL SOAP USING CURCUMA AMADA ROXBURGH AND PRUNUS DULCIS
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i4.46834Keywords:
Mango Ginger, Antifungal activity, GC-MS Analysis, Antifungal Herbal Soap, Phytochemical, Anntioxidant, Curcuma amadaAbstract
Objective: Mango ginger (Curcuma amada Roxburgh) belongs to the Zingiberaceae family, a type of annual plant. It is commonly used for culinary and therapeutic purposes, which also has the maximum amount of health benefits. The main objective of the study is formulation of antifungal herbal soap which is alternate to chemical products.
Methods: In the present study, aqueous, ethanol, and chloroform extract of mango ginger were subjected to qualitative and quantitative phytochemical analysis and determined the antioxidant activity using DPPH assay and FRAP assay. Furthermore, the ash and moisture content of the rhizome was analyzed. The aqueous extract of mango ginger is used in the GC-MS study to identify the compounds present in the mango ginger. The oil was extracted from mango ginger and subjected to antifungal activity by the well-diffusion method against three fungi, namely, Candida tropicalis, Candida auris, and Candida albicans. Using the extracted mango ginger oil and almond oil, antifungal Herbal Soap is formulated.
Result: This study shows that aqueous extract of mango ginger has a greater number of carbohydrates, phenol, flavonoids, and antioxidant activity than other extracts. Antifungal activity is observed at various concentrations of extract, which shows that the highest zone of inhibition is 1.4 cm for C. auris. The formulated soap has a good aroma, and color – mustard yellow. This soap is base in nature and its pH is 8.9.
Conclusion: According to the above studies, the formulated antifungal herbal soap may rectify the problems of fungal skin infections.
Downloads
References
Basra MK, Shahrukh M. Burden of skin disease. Expert Rev Pharmacoecon Outcomes Res 2009;9:271-83.
Solanki R. Treatment of skin diseases through medicinal plants in different regions of the world. Int J Biomed Res 2011;2:73-88. doi: https://doi.org/10.7439/ijbr.v2i1.82
Afsar Z, Khanam S. Formulation and evaluation of polyherbal soap and hand sanitizer. Int Res J Pharm 2016;7:54-7. doi: 10.21275/ MR21828174927
Pawar BT. Antifungal activity of some stem extracts against seed-borne pathogenic fungi. J Phytol 2011;3:49-51.
Al-Qudah TS, Malloh SA, Nawaz A, Ayub MA, Nisar S, Muhammad I, et al. Mango ginger (Curcuma amada Roxb.): A phytochemical mini review. Int J Chem Biochem Sci 2017;11:51-7.
Padalia RC, Verma RS, Velusamy S, Chauhan A, Chanotiya CS, Yadav A. Volatile terpenoid compositions of leaf and rhizome of Curcuma amada Roxb. From Northern India. J Essential Oil Res 2013;25:17-22.
Debnath S, Babu MN, Dega M, Bharathi K, Jyothsna T, Revathi D, et al. Formulation and evaluation of liquid soap containing herbal antimicrobial agent. Res J Pharmacogn Phytochem 2011;3:225-31.
Fluit AC, Schmits FJ, Verhoef J. Frequency of isolation of pathogens from bloodstream, nosocomial pneumonia, skin and soft tissue, and urinary tract infections occurring in European patients. Eur J Clin Microbiol Infect Dis 2001;20:188-91.
Randeep G, Vandna K, Amandeep S. Phytochemical investigation and evaluation of anthelmintic activity of Curcuma amada and Curcuma caesia-a comparative study. J Ethnopharmacol 2011;2:1-4.
Sutar J, Monalisa K, Pati K, Chauhan VB, Behera S. Qualitative and quantitative phytochemical analysis and antioxidant activity of Curcuma Amada Roxb: An important medicinal plant. Plant Arch 2020;20:193-6.
Tejavathi DH, Sujatha BS, Karigar CS. Physicochemical properties of starch obtained from Curcuma karnatakensis-a new botanical source for high amylose content. J Hellion 2020;6:e03169. doi: 10.1016/j. heliyon.2020.e03169. PMID: 32042958
Chan E, Lim Y, Omar M. Antioxidant and antibacterial activity of leaves of Etlingera species (Zingiberaceae) in peninsular Malaysia. Food Chem 2007;104:1586-93.
Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol 1966;45:493-6. PMID: 5325707
Policegoudra RS, Abiraj K, Gowda D, Aradhya SM. Isolation and characterization of antioxidant and antibacterial compound from mango ginger (Curcuma amada Roxb.) rhizome. J Chromatogr B Analyt Technol Biomed Life Sci 2007;85:40-8.
Akter J, Takara K, Islam MZ, Hossain MA, Sano A, Hou DX. Isolation and structural elucidation of antifungal compounds from Curcuma amada. Asian Pac J Trop Med 2019;12:123-9. doi: 10.4103/1995- 7645.254938
Anita T, Prakash O, Punetha H, Pant AK. Phytochemical profiling and antifungal activity of essential oil and rhizome extracts of Curcuma amada Roxb. Org Med Chem IJ 2017;4:555627. doi: 10.19080/ OMCIJ.2017.04.555627
Rajasree PH, Vishwanad V, Cherian M. Eldhose J, Singh R. Formulation and evaluation of antiseptic polyherbal ointment. Int J Pharmacy Life Sci 2012;3:2021-31.
Jatoi SA, Kikuchi A, Gilani SA, Watanabe KN. Phytochemical, pharmacological and ethnobotanical studies in mango ginger (Curcuma amada Roxb.; Zingiberaceae). Phytother Res 2007;21:507-16.
Published
How to Cite
Issue
Section
Copyright (c) 2023 HARI PRASATH C., DIVYAPRIYA S., DHANA RANGESH KUMAR V.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
