FORMULATION AND EVALUATION OF TRAMADOL HYDROCHLORIDE-LOADED NIOSOMAL GEL BY ETHER INJECTION METHOD

Amena Amreen; RATNAMALA KV

doi:10.22159/ajpcr.2023.v16i5.47133

Authors

Amena Amreen Department of Pharmaceutics, RBVRR Women’s College of Pharmacy (Affiliated to Osmania University), Hyderabad, Telangana, India.
RATNAMALA KV Department of Pharmaceutics, RBVRR Women’s College of Pharmacy (Affiliated to Osmania University), Hyderabad, Telangana, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i5.47133

Keywords:

Niosomes, Cholesterol, Span 60, Tween 80, Tramadol hydrochloride, Entrapment efficiency

Abstract

Objective: The primary goal of this study was to develop a topical gel containing tramadol hydrochloride-loaded Niosomes injection technique as the vesicular carrier for site-specific delivery.

Methods: The tramadol hydrochloride-loaded niosomes were created by varying the ratios of nonionic surfactants (Tween 80, Tween 60, Tween 20, Span 20, Span 60, and Span 80) and cholesterol while keeping the drug concentration constant.

Results and Discussion: Each formulation was examined for drug content, entrapment efficiency, mean vesicular diameter, zeta potential, and in-vitro drug release tests. Among the six formulations, the N2 formulation containing the drug and Tween 20 demonstrated maximal drug content of 96.7%, entrapment efficiency of 99%, mean vesicular diameter of 319 nm, zeta potential of −28 mV, in-vitro drug release of 90.14% in 12 h, and the drug release followed the zero-order with non-fickian diffusion mechanism by ether injection method. As a result, the ether injection approach is an optimal procedure for the synthesis of tramadol hydrochloride niosomes.

Conclusion: By comparing Niosomal gel with plain gel Niosomal gel indicated better results than plain gel.

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References

Aggarwal D, Kaur IP. Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system. Int J Pharm 2005;290:155-9.

Handjani-Vila RM, Ribier A, Rondot B, Vanlerberge G. Non-ionic lipid lamellar phase dispersions in cosmetic products. Int J Cosmet Sci 1979;1:303-14.

Solankia A. Aceclofenac proniosome preparation, characterisation, optimization, and stability investigations. Iran J Pharm Res 2008;7: 237-46.

Szoka F Jr., Papahadjopoulos D. Comparative properties and methods of preparation of lipid vesicles (liposomes). Annu Rev Biophys Bioeng 1980;9:9467-508.

Sundaresan P. A comparison of aceclofenac niosome preparation methodologies. Int J Pharm Sci Rev Res 2012;25:75-8.

Kaur IP, Garg A, Singla AK, Aggarwal D. Vesicular systems in ocular delivery: An overview. Int J Pharm 2004;269:1-14.

Supraja R, Sailaja AK . Formulation and evaluation of mefenamic acid loaded ethosomal gel by hot and cold technique. Nano Biomed Eng 2017;9:27-35.

Azmin MN, Florence AT, Handjani-Vila RM, Stuart JF, Vanlerberghe G, Whittaker GS. The effect of nonionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. J Pharm Pharmacol 1985;37:237-42.

Moser P, Marchand-Arvier M, Labrude P, Handjani-Vila RM, Vigneron C. Formulation and evaluation of niosomes d’hemoglobine. Pharm Acta Helv 1989;64:192-202.

Kumar YP, Kumar KV, Shekar R, Ravi M, Kishore VS. Formulation and evaluation of econozole Niosomes. Sch Acad J Pharm 2013;2: 315-8.

Kamboj S, Saini V, Bala S, Sharma G. Formulation and characterization of drug loaded niosomal gel for anti-inlammatory activity. Int J Med Health Pharm Biomed Eng 2013;7:877-81.

Uchegbu IF, Vyas SP. Non-ionic surfactant-based vesicles (niosomes) in drug delivery. Int J Pharm 1998;172:33-70.

Malhotra M, Jain NK. Niosomes as drug carriers. Indian Drugs 1994;31:81-6.