PREVALENCE AND PROFILE OF BETA-THALASSEMIA: A PROSPECTIVE ANALYSIS AT A TERTIARY CARE CANTER

Authors

  • Sheetal Mahajan Department of Pathology, Grant Medical College and JJ Group of Hospital, Byculla, Mumbai, India. https://orcid.org/0000-0003-0985-7046
  • SACHIN DHULE Department of Pediatrics, MGM Hospital, Aurangabad, Maharashtra, India.
  • TAKSANDE RV Department of Pathology, Grant Medical College and JJ Group of Hospital, Byculla, Mumbai, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i5.47258

Keywords:

Beta-thalassemia, Hemoglobinopathies, Hematological parameters, Prevalence

Abstract

Objective: The objective of the present investigation was to identify the hematological profile of β-thalassemia trait.

Methods: The cross-sectional investigation, which included 186 patients, was conducted in a tertiary care hospital’s hematology unit of the pathology department from November 2012 to May 2014.

Results: About 73.11% of the study population was in the 21–50 years age group followed by 18.27% in the age group 0–20 years. About 8.62% of the study population was in between 51 and 75 years of age. Eighty-six (46.23%) men and 100 (53.77%) women made up the study’s sample. In our study, India had a 19% overall prevalence of the thalassemia trait. In the research, we conducted we found that those with the beta-thalassemia trait (BTT) had much lower levels of red blood cells (RBC) parameters except RBC count which is slightly raised than those without the trait.

Conclusion: There is a significant prevalence of BTT in our population. This information will prove helpful to health policy managers in making informed decisions on how to design accessible screening programs for BTT.

Downloads

Download data is not yet available.

References

Kohne E. Hemoglobinopathies: Clinical manifestations, diagnosis, and treatment. Dtsch Ärztebl Int 2011;108:532-40. doi: 10.3238/ arztebl.2011.0532, PMID 21886666

Madan N, Sharma S, Sood SK, Colah R, Bhatia LH. Frequency of β-thalassemia trait and other hemoglobinopathies in northern and western India. Indian J Hum Genet 2010;16:16-25. doi: 10.4103/0971- 6866.64941, PMID 20838487

Demir A, Yarali N, Fisgin T, Duru F, Kara A. Most reliable indices in differentiation between thalassemia trait and iron deficiency anemia. Pediatr Int 2002;44:612-6. doi: 10.1046/j.1442-200x.2002.01636.x, PMID 12421257

Schoorl M, Schoorl M, Linssen J, Villanueva MM, NoGuera JA, Martinez PH, et al. Efficacy of advanced discriminating algorithms for screening on iron-deficiency anemia and β-thalassemia trait: A multicenter evaluation. Am J Clin Pathol 2012;138:300-4. doi: 10.1309/AJCP20UTTCAYKUDX, PMID 22904143

Rund D, Rachmilewitz E. β-thalassemia. N Engl J Med 2005;353:1135- 46. doi: 10.1056/NEJMra050436, PMID 16162884

Salah NB, Bou-Fakhredin R, Mellouli F, Taher AT. Revisiting beta thalassemia intermedia: Past, present, and future prospects. Hematology 2017;22:607-16. doi: 10.1080/10245332.2017.1333246, PMID 28589785

Mosca A, Paleari R, Ivaldi G, Galanello R, Giordano PC. The role of haemoglobin A2 testing in the diagnosis of thalassaemias and related haemoglobinopathies. J Clin Pathol 2009;62:13-7. doi: 10.1136/ jcp.2008.056945, PMID 19103851

Jameel T, Baig M, Ahmed I, Hussain MB, Alkhamaly MB. Differentiation of beta thalassemia trait from iron deficiency anemia by hematological indices. Pak J Med Sci 2017;33:665-9. doi: 10.12669/ pjms.333.12098, PMID 28811791

Bhargava M, Kumar V, Pandey H, Singh V, Misra V, Gupta P. Role of hematological indices as a screening tool of beta thalassemia trait in Eastern Uttar Pradesh: An institutional study. Indian J Hematol Blood Transfus 2020;36:719-24. doi: 10.1007/s12288-020-01282-z, PMID 33100716

Mohanty D, Colah RB, Gorakshakar AC, Patel RZ, Master DC, Mahanta J, et al. Prevalence of β-thalassemia and other haemoglobinopathies in six cities in India: A multicentre study. J Community Genet 2013;4:33-42. doi: 10.1007/s12687-012-0114-0, PMID 23086467

Mondal SK, Mandal S. Prevalence of thalassemia and hemoglobinopathy in eastern India: A 10-year high-performance liquid chromatography study of 119,336 cases. Asian J Transfus Sci 2016;10:105-10. doi: 10.4103/0973-6247.175424, PMID 27011683

Kiss TL, Ali MA, Levine M, Lafferty JD. An algorithm to aid in the investigation of thalassemia trait in multicultural populations. Arch Pathol Lab Med 2000;124:1320-3. doi: 10.5858/2000-124-1320-AATAIT, PMID 10975930

Roth IL, Lachover B, Koren G, Levin C, Zalman L, Koren A. Detection of β-thalassemia carriers by red cell parameters obtained from automatic counters using mathematical formulas. Mediterr J Hematol Infect Dis 2018;10:e2018008. doi: 10.4084/MJHID.2018.008, PMID 29326805

Published

07-05-2023

How to Cite

Mahajan, S., S. DHULE, and T. RV. “PREVALENCE AND PROFILE OF BETA-THALASSEMIA: A PROSPECTIVE ANALYSIS AT A TERTIARY CARE CANTER”. Asian Journal of Pharmaceutical and Clinical Research, vol. 16, no. 5, May 2023, pp. 174-6, doi:10.22159/ajpcr.2023.v16i5.47258.

Issue

Section

Original Article(s)