PREVALENCE AND PROFILE OF BETA-THALASSEMIA: A PROSPECTIVE ANALYSIS AT A TERTIARY CARE CANTER
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i5.47258Keywords:
Beta-thalassemia, Hemoglobinopathies, Hematological parameters, PrevalenceAbstract
Objective: The objective of the present investigation was to identify the hematological profile of β-thalassemia trait.
Methods: The cross-sectional investigation, which included 186 patients, was conducted in a tertiary care hospital’s hematology unit of the pathology department from November 2012 to May 2014.
Results: About 73.11% of the study population was in the 21–50 years age group followed by 18.27% in the age group 0–20 years. About 8.62% of the study population was in between 51 and 75 years of age. Eighty-six (46.23%) men and 100 (53.77%) women made up the study’s sample. In our study, India had a 19% overall prevalence of the thalassemia trait. In the research, we conducted we found that those with the beta-thalassemia trait (BTT) had much lower levels of red blood cells (RBC) parameters except RBC count which is slightly raised than those without the trait.
Conclusion: There is a significant prevalence of BTT in our population. This information will prove helpful to health policy managers in making informed decisions on how to design accessible screening programs for BTT.
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References
Kohne E. Hemoglobinopathies: Clinical manifestations, diagnosis, and treatment. Dtsch Ärztebl Int 2011;108:532-40. doi: 10.3238/ arztebl.2011.0532, PMID 21886666
Madan N, Sharma S, Sood SK, Colah R, Bhatia LH. Frequency of β-thalassemia trait and other hemoglobinopathies in northern and western India. Indian J Hum Genet 2010;16:16-25. doi: 10.4103/0971- 6866.64941, PMID 20838487
Demir A, Yarali N, Fisgin T, Duru F, Kara A. Most reliable indices in differentiation between thalassemia trait and iron deficiency anemia. Pediatr Int 2002;44:612-6. doi: 10.1046/j.1442-200x.2002.01636.x, PMID 12421257
Schoorl M, Schoorl M, Linssen J, Villanueva MM, NoGuera JA, Martinez PH, et al. Efficacy of advanced discriminating algorithms for screening on iron-deficiency anemia and β-thalassemia trait: A multicenter evaluation. Am J Clin Pathol 2012;138:300-4. doi: 10.1309/AJCP20UTTCAYKUDX, PMID 22904143
Rund D, Rachmilewitz E. β-thalassemia. N Engl J Med 2005;353:1135- 46. doi: 10.1056/NEJMra050436, PMID 16162884
Salah NB, Bou-Fakhredin R, Mellouli F, Taher AT. Revisiting beta thalassemia intermedia: Past, present, and future prospects. Hematology 2017;22:607-16. doi: 10.1080/10245332.2017.1333246, PMID 28589785
Mosca A, Paleari R, Ivaldi G, Galanello R, Giordano PC. The role of haemoglobin A2 testing in the diagnosis of thalassaemias and related haemoglobinopathies. J Clin Pathol 2009;62:13-7. doi: 10.1136/ jcp.2008.056945, PMID 19103851
Jameel T, Baig M, Ahmed I, Hussain MB, Alkhamaly MB. Differentiation of beta thalassemia trait from iron deficiency anemia by hematological indices. Pak J Med Sci 2017;33:665-9. doi: 10.12669/ pjms.333.12098, PMID 28811791
Bhargava M, Kumar V, Pandey H, Singh V, Misra V, Gupta P. Role of hematological indices as a screening tool of beta thalassemia trait in Eastern Uttar Pradesh: An institutional study. Indian J Hematol Blood Transfus 2020;36:719-24. doi: 10.1007/s12288-020-01282-z, PMID 33100716
Mohanty D, Colah RB, Gorakshakar AC, Patel RZ, Master DC, Mahanta J, et al. Prevalence of β-thalassemia and other haemoglobinopathies in six cities in India: A multicentre study. J Community Genet 2013;4:33-42. doi: 10.1007/s12687-012-0114-0, PMID 23086467
Mondal SK, Mandal S. Prevalence of thalassemia and hemoglobinopathy in eastern India: A 10-year high-performance liquid chromatography study of 119,336 cases. Asian J Transfus Sci 2016;10:105-10. doi: 10.4103/0973-6247.175424, PMID 27011683
Kiss TL, Ali MA, Levine M, Lafferty JD. An algorithm to aid in the investigation of thalassemia trait in multicultural populations. Arch Pathol Lab Med 2000;124:1320-3. doi: 10.5858/2000-124-1320-AATAIT, PMID 10975930
Roth IL, Lachover B, Koren G, Levin C, Zalman L, Koren A. Detection of β-thalassemia carriers by red cell parameters obtained from automatic counters using mathematical formulas. Mediterr J Hematol Infect Dis 2018;10:e2018008. doi: 10.4084/MJHID.2018.008, PMID 29326805
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