A PROSPECTIVE STUDY FOR THE EVALUATION OF NERVE CONDUCTION ABNORMALITIES IN NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS

LORD KRISHNA GOVINDARAJU; KAMALAKANNAN VADIVEL; PRASHANTH TALIKOTI; RAVI KUMAR T; JEYALAKSHMI D; VENGADESH PRABHU V

doi:10.22159/ajpcr.2023.v16i2.47299

Authors

LORD KRISHNA GOVINDARAJU Department of Physiology, GMC and ESI Hospital, Coimbatore, Tamil Nadu, India.
KAMALAKANNAN VADIVEL Department of Physiology, ESIC Medical College and Hospital, Kalaburagi, Karnataka, India.
PRASHANTH TALIKOTI Department of Biochemistry, ESIC Medical College and Hospital, Kalaburagi, Karnataka, India.
RAVI KUMAR T Department of Medicine, GMC and ESI Hospital, Coimbatore, Tamil Nadu, India.
JEYALAKSHMI D Department of Pharmacology, Government Medical College and ESI Hospital, Coimbatore, Tamil Nadu, India.
VENGADESH PRABHU V Department of Physiology, Tiruppur Medical College, Tiruppur, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i2.47299

Keywords:

Type 2 diabetes mellitus, Peripheral neuropathy, Newly diagnosed diabetes, Nerve conduction studies

Abstract

Objectives: Peripheral neuropathy is the one of the frequently encountered complication of type 2 diabetes mellitus (T2DM). Although, the prevalence of diabetic peripheral neuropathy is associated with the diabetes duration, in some cases, the state of neuropathy is evident at the time of diagnosis. In this backdrop, the present study was carried out to evaluate the nerve conduction abnormalities in newly diagnosed T2DM.

Methods: This was a prospective study carried out on 30 newly diagnosed T2DM within a time range of 1 month. The patient symptoms such as weakness, burning and tingling senzation, hyperesthesia, and foot ulcer and gait abnormalities were recorded. Nerve conduction analysis of upper limb and lower limb of non-dominant hand side was done using neuro pack S1 machine.

Results: Thirty newly diagnosed T2DM patients were enrolled in the present study. The mean age of the patients was found to be 58.12±15.28 years. Distal motor latencies were elevated in T2DM patients as compared to the controls (p<0.05). Further, there was significant prolongation of F-wave latencies in the upper and Lower limbs of the patients as compared to the controls (p<0.05). In addition, there was a significant decrease in sensory conduction velocities in T2DM patients as that of the controls (p<0.05).

Conclusion: The study concludes that newly diagnosed T2DM is susceptible to DPN with high incidence rates. Hence, it is essential to perform the nerve conduction studies in newly diagnosed T2DM patients for the early detection and better management and also to prevent the complications.

Downloads

Download data is not yet available.

References

Leon BM, Maddox TM. Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes 2015;6:1246-58. doi: 10.4239/wjd. v6.i13.1246, PMID 26468341

Harris MI. Undiagnosed NIDDM: Clinical and public health issues. Diabetes Care 1993;16:642-52. doi: 10.2337/diacare.16.4.642, PMID 8462395.

Kostev K, Jockwig A, Hallwachs A, Rathmann W. Prevalence and risk factors of neuropathy in newly diagnosed Type 2 diabetes in primary care practices: A retrospective database analysis in Germany and U.K. Prim Care Diabetes 2014;8:250-5. doi: 10.1016/j.pcd.2014.01.011, PMID 24530101

Zaharia OP, Strassburger K, Strom A, Bönhof GJ, Karusheva Y, Antoniou S, et al. Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: A 5-year follow-up study. Lancet Diabetes Endocrinol 2019;7:684-94. doi: 10.1016/S2213- 8587(19)30187-1, PMID 31345776

Kostev K, Rathmann W. Diabetic retinopathy at diagnosis of Type 2 diabetes in the UK: A database analysis. Diabetologia 2013;56:109-11. doi: 10.1007/s00125-012-2742-7, PMID 23052061

Pradeepa R, Rema M, Vignesh J, Deepa M, Deepa R, Mohan V. Prevalence and risk factors for diabetic neuropathy in an urban South Indian population: The chennai urban rural epidemiology study (CURES-55). Diabet Med 2008;25:407-12. doi: 10.1111/j.1464- 5491.2008.02397.x, PMID 18294224

Paul UK, Sinharay K, Bhattacharyya AK, Pal SK. Update in diabetic neuropathy with special reference to Indian Scenario. J Indian Med Assoc 2012;110:616-22. PMID 23741834

Agarwal S, Lukhmana S, Kahlon N, Malik P, Nandini H. Nerve conduction study in neurologically asymptomatic diabetic patients and correlation with glycosylated hemoglobin and duration of diabetes. Natl J Physiol Pharm Pharmacol 2018;8:1533-1538. doi: 10.5455/ njppp.2018.8.0826828082018

De Souza RJ, de Souza A, Nagvekar MD. Nerve conduction studies in diabetics presymptomatic and symptomatic for diabetic polyneuropathy. J Diabetes Complications 2015;29:811-7. doi: 10.1016/j.jdiacomp.2015.05.009, PMID 26049172

Rota E, Quadri R, Fanti E, Isoardo G, Poglio F, Tavella A, et al. Electrophysiological findings of peripheral neuropathy in newly diagnosed Type II diabetes mellitus. J Peripher Nerv Syst 2005;10:348-53. doi: 10.1111/j.1085-9489.2005.00046.x, PMID 16279983

Singh RB, Chandel K, Kumar S. Nerve conduction study findings of subclinical diabetic neuropathy in newly diagnosed diabetic patients. Indian J Neurosci 2015;1:1-7.

Gill HK, Yadav SB, Ramesh V, Bhatia E. A prospective study of prevalence and association of peripheral neuropathy in Indian patients with newly diagnosed Type 2 diabetes mellitus. J Postgrad Med 2014;60:270-5. doi: 10.4103/0022-3859.138750, PMID 25121366

Vinik AI. Clinical practice. Diabetic sensory and motor neuropathy. N Engl J Med 2016;374:1455-64. doi: 10.1056/NEJMcp1503948, PMID 27074068

Pan H, Jian F, Lin J, Chen N, Zhang C, Zhang Z, et al. F-wave latencies in patients with diabetes mellitus. Muscle Nerve 2014;49:804-8. doi: 10.1002/mus.24127, PMID 24259350