A COMPARATIVE STUDY TO DETERMINE THE EFFECTS OF VARIABLE CONCENTRATIONS AND DIFFERENT ROUTES OF ADMINISTRATION OF LIDOCAINE IN SUPPRESSING COUGH AND ON HEMODYNAMIC RESPONSE DURING EXTUBATION IN PEDIATRIC AGE GROUP: AN OBSERVATIONAL PROSPECTIVE STUDY

NIDHA HAFIZ; SUMEERA FAYAZ; SHOWKAT HUSSAIN TALI; SHEIKH IRSHAD; MALIK ZAFAR IQBAL

doi:10.22159/ajpcr.2023.v16i2.47350

Authors

NIDHA HAFIZ Department of H&M.
SUMEERA FAYAZ Department of Anesthesiology, SKIMS, Srinagar, Jammu and Kashmir, India.
SHOWKAT HUSSAIN TALI Department of Pediatrics, Government Medical College, Anantnag, Jammu and Kashmir, India.
SHEIKH IRSHAD Department of Anesthesiology, SKIMS, Srinagar, Jammu and Kashmir, India.
MALIK ZAFAR IQBAL Department of Anesthesiology, Government Medical College, Anantnag, Jammu and Kashmir, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i2.47350

Keywords:

Lidocaine, Extubation, Endotracheal spray, IV lidocaine

Abstract

Objectives: The objectives of this study were to compare the effects of different concentrations of lidocaine (2% endotracheal [ET] spray; 10% ET spray; and 2% intravenous [IV]) in suppressing cough and on hemodynamic response during extubation in pediatric age groups; an observational prospective study.

Methods: Ninety patients were enrolled for the study and divided into three groups. In Group A, patients were administered (1 mg/kg) of 2% lidocaine ET spray 5 min before extubation; in Group B, patients were administered (1 mg/kg) of 10% lidocaine ET spray 5 min before extubation; and in Group C patients were administered (1 mg/kg) 2% lidocaine IV 3 min before extubation. The three groups were compared for hemodynamic parameters, incidence of cough, breathing pattern, and need for continuous positive airway pressure (CPAP).

Results: There was significant attenuation of hemodynamic parameters and less incidence of cough and labored breathing in patient receiving either 10% ET or 2% IV lidocaine. As compared to 2% ET lidocaine, requirement of CPAP support was less in patients who received 10% lidocaine. Patients who were administered 2% IV lidocaine did not receive any CPAP support postextubation.

Conclusion: As compared to 2% lidocaine spray postextubation, both 10% lidocaine spray and 2% IV lidocaine postextubation have significantly positive effect on suppression of cough and on hemodynamic parameters.

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