ANTIBIOTIC PROPHYLAXIS USE IN PATIENTS ADMITTED IN GENERAL SURGERY DEPARTMENT AT A TERTIARY CARE TEACHING HOSPITAL IN HARYANA

ARVIND NARWAT; MAMTA SHARMA; PREM PRAKASH KHOSLA

doi:10.22159/ajpcr.2023.v16i6.47417

Authors

ARVIND NARWAT Department of Pharmacology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, Haryana, India.
MAMTA SHARMA Department of Medical Pharmacology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, Haryana, India.
PREM PRAKASH KHOSLA Department of Pharmacology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, Haryana, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i6.47417

Keywords:

Antibiotic prophylaxis, Ceftriaxone, Nosocomial infections, Surgical site infections

Abstract

Objective: In India, due to a lack of adequate information and guidelines for antimicrobial prophylaxis in surgery, there is a need to generate baseline data on the pattern of the use of prophylactic antibiotics. Hence, we planned this study with an objective to study the antimicrobial prophylaxis use in the patients admitted to the general surgery department.

Methods: The present study was a prospective observational study conducted in the department of pharmacology in collaboration with the department of surgery with the prior approval of the Institutional Ethical committee. All data were retrieved from the patients’ case records. Using a convenient sampling method, 100 adult patients who underwent surgical procedures in MMIMSR during the study period were taken.

Results: A total of 100 patients admitted to the general surgery department of MMIMSR fulfilling the inclusion and exclusion criteria were enrolled. Out of 100 patients, 52 (52%) were male and 48 (48%) were female patients who underwent surgery and the majority of the patients enrolled are between 48 and 58 years (40%) of age. Cholecystectomy (28%) was the most frequent performed surgery type followed by hernial repair (24%) and hemorrhoidectomy (14%) Among all cases, surgical antibiotic prophylaxis was recommended in 93 (93%) patients. The most preferred route of administration of surgical antibiotic prophylaxis was parenteral route 100 (100%) and ceftriaxone was most commonly prophylactically prescribed antibiotic.

Conclusion: Surgical site infection is the most common nosocomial infections in surgical patients accounting for prolonged hospital stay, mortality, and increased cost of care. According to the analyzed results of our study and from view of literature, the present study provides us patterns of antibiotic usage in patients admitted in surgery wards.

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References

Brunton L, Chabner BA, Knollman B. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York: McGraw- Hill Medical; 2011. p. 1363-6.

Enzler MJ, Berbari E, Osmon DR. Antimicrobial prophylaxis in adults. Mayo Clin Proc 2011;86:686-701. doi: 10.4065/mcp.2011.0012, PMID 21719623

Sattar F, Sattar Z, Zaman M, Akbar S. Frequency of post-operative surgical site infections in a tertiary care hospital in Abbottabad, Pakistan. Cureus 2019;11:e4243. doi: 10.7759/cureus.4243, PMID 31131166

Leekha S, Terrell CL, Edson RS. General principles of antimicrobial therapy. Mayo Clin Proc 2011;86:156-67. doi: 10.4065/mcp.2010.0639, PMID 21282489

Owens CD, Stoessel K. Surgical site infections: Epidemiology, microbiology and prevention. J Hosp Infect 2008;70 Suppl 2:3-10. doi: 10.1016/S0195-6701(08)60017-1, PMID 19022115

Onyekwelu I, Yakkanti R, Protzer L, Pinkston CM, Tucker C, Seligson D. Surgical wound classification and surgical site infections in the orthopaedic patient. J Am Acad Orthop Surg Glob Res Rev 2017;1:e022. doi: 10.5435/JAAOSGlobal-D-17-00022, PMID 30211353

Dutescu IA, Hillier SA. Encouraging the development of new antibiotics: Are financial incentives the right way forward? A systematic review and case study. Infect Drug Resist 2021;14:415-34. doi: 10.2147/IDR. S287792, PMID 33574682

Rehan HS, Kakkar AK, Goel S. Pattern of surgical antibiotic prophylaxis in a tertiary care teaching hospital in India. Int J Infect Control 2010;6:1-6.

Elbur AI, Yousif MA, Elsayed AS, Abdel-Rahman ME. An audit of prophylactic surgical antibiotic use in a Sudanese Teaching Hospital. Int J Clin Pharm 2013;35:149-53. doi: 10.1007/s11096-012-9719-y, PMID 23135836

Ram VG, VidyaSagar RA, Krishnan GG, Senthivelan M. Surgical antibiotic prophylaxis in a tertiary care teaching hospital in India. World J Pharm Pharm Sci 2014;3:968-76.

Revathi R, Sarala N, Bhaskaran A. Prescribing pattern of antimicrobials in patients during post-operative period-an observational study. J Adv Med Med Res 2015;5:1213-9.

Sharma P, Goel D. Utilization assessment of antimicrobial prophylaxis in surgical patients at tertiary care teaching hospital. Saudi J Health Sci 2018;7:23-7.