THYROID FUNCTION TEST IN SICKLE-CELL DISEASE

JINGYASA SWAIN; BISWAJIT MOHANTY; Nayan kumar patel; chakradhar majhi

doi:10.22159/ajpcr.2023.v16i7.47607

Authors

JINGYASA SWAIN Department of General Medicine, MKCG Medical College and Hospital, Berhampur, Odisha, India
BISWAJIT MOHANTY Department of General Medicine, Medical College-IMS and SUM Hospital, Bhubaneswar, Odisha, India
Nayan kumar patel Department of Cardiology, Medical College, VIMSAR, Sambalpur, Odisha, India
chakradhar majhi Department of General Medicine, Medical College-VIMSAR, Sambalpur, Odisha, India

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i7.47607

Keywords:

Sickle-cell anemia, Sickle-cell disease, Hypothyroidism, Thyroid Function test

Abstract

Objective: This cross-sectional study aimed to evaluate the thyroid function (triiodothyronine [T3], thyroxine [T4], and thyroid-stimulating hormone [TSH] levels) in patients with sickle-cell disease (SCD).

Methods: This cross-sectional observational study was conducted in the general medicine department of the Veer Surendra Sai Medical College and Hospital, Burla, Sambalpur, Odisha (India). The investigation was performed in the sickle cell clinic, medical ward, and outpatient department of the institute. This study was conducted from November 2019 to October 2021. Sixty-eight patients with SCD were enrolled for assessing their thyroid function. The reference ranges for serum T4 (4.5–12 μg/dL), serum T3 (60–200 ng/dL), and TSH (0.3–5.5 uIU/mL) were defined to evaluate the thyroid function.

Results: The average TSH, mean T4 level, and mean T3 level among the patients were 4.02, 4.67, and 74.15, respectively. The incidence rates of hypothyroidism and euthyroid status were 23.5% and 76.5%, respectively. While 9.59 g/dL was the mean hemoglobin level, 11–16 g/dL was observed in 42.6% of patients compared to <11 g/dL in 57.4% of patients. Patients within the age group of 14-25 years had a higher incidence of hypothyroidism (62.5%). The differences in hypothyroidism between males and females were statistically insignificant (68.8% vs. 31.2%, p = 0.11).

Conclusion: Patients with SCD had clinically significant reductions in T3 and T4 levels. In addition, higher levels of TSH and reductions in endogenous T3/T4 levels were observed in male patients. Overall, SCD was associated with a higher incidence of hypothyroidism.

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Author Biography

Nayan kumar patel, Department of Cardiology, Medical College, VIMSAR, Sambalpur, Odisha, India

Assistant professor, Department of Cardiology, Medical College, VIMSAR, Burla, Sambalpur, Odisha

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