DULOXETINE HYDROCHLORIDE INDUCED PARESTHESIA - A CASE REPORT
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i8.47633Keywords:
Duloxetine hydrochloride, Paraesthesia, Immune compramised patient, DepressionAbstract
A 45-year-old HIV-positive female patient experienced a generalized burning sensation after the administration of one dose of duloxetine 20 mg. The patient’s concurrent medications include a fixed drug combination of nevirapine 200 mg, Lamivudine 150 mg, and Zidovudine 300 mg, twice daily for 5 years. The patient recovered from the generalized burning sensation the next day after the withdrawal of duloxetine. From the causal relationship assessment, we observed that neither the disease, comorbid conditions, nor concurrent medications were found responsible for the burning sensation experience in this patient. Available data from post-marketing surveillance of duloxetine suggest that to date the incidence of duloxetine-induced burning sensation of skin was reported to be 1 in 870 patients. Health-care providers should watch for this rare but important adverse effect of duloxetine.
Downloads
References
Dhaliwal JS, Spurling BC, Molla M. Duloxetine. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2022.
Rezaei S, Ahmadi S, Rahmati J, Hosseinifard H, Dehnad A, Aryankhesal A, et al. Global prevalence of depression in HIV/AIDS: A systematic review and meta-analysis. BMJ Support Palliat Care 2019;9:404-12. doi: 10.1136/bmjspcare-2019-001952, PMID 31537580
Seid S, Abdu O, Mitiku M, Tamirat KS. Prevalence of depression and associated factors among HIV/AIDS patients attending antiretroviral therapy clinic at Dessie referral hospital, South Wollo, Ethiopia. Int J Ment Health Syst 2020;14:55. doi: 10.1186/s13033-020-00389-0, PMID 32742304
Zuniga JA, Yoo-Jeong M, Dai T, Guo Y, Waldrop-Valverde D. The role of depression in retention in care for persons living with HIV. AIDS Patient Care STDS 2016;30:34-8. doi: 10.1089/apc.2015.0214, PMID 26544915
Siegfried N, Akena DH, Stein DJ, Obuku EA, Joska JA, Eshun-Wilson I. Antidepressants for depression in adults with HIV infection. Cochrane Database Syst Rev 2018;1:CD008525.
Available from: https://www.ehealthme.com/ehm/ds/cymbalta/burning-sensation
Woo YS, Bahk WM. Burning paresthesia related to duloxetine therapy. J Clin Psychopharmacol 2014;34:392-4. doi: 10.1097/ JCP.0000000000000067, PMID 24633002
Oulis P, Masdrakis VG, Karakatsanis NA, Karapoulios E, Kouzoupis AV, Soldatos CR. Duloxetine-induced cutaneous adverse reaction. J Clin Psychopharmacol 2008;28:104-5. doi: 10.1097/ jcp.0b013e318160863e, PMID 18204353
Meyboom RH, Hekster YA, Egberts AC, Gribnau FW, Edwards IR. Causal or casual? The role of causality assessment in pharmacovigilance. Drug Saf 1997;17:374-89. doi: 10.2165/00002018-199717060-00004, PMID 9429837
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-45. doi: 10.1038/clpt.1981.154, PMID 7249508
Published
How to Cite
Issue
Section
Copyright (c) 2023 SAI PAWAN RAMESH ADEPU, Birendra Srivastava, Ramesh Adepu
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
