EVALUATION OF ACTIVITY OF ALTERNANTHERA SESSILIS LEAVES AQUEOUS EXTRACT ON PLATELET COUNT IN DRUG-INDUCED THROMBOCYTOPENIA IN ALBINO RATS

Nayana MR; DEEPA PATIL; SATHISHA AITHAL; APOORVA BM

doi:10.22159/ajpcr.2023.v16i8.47738

Authors

Nayana MR Department of Pharmacology, SSIMS and RC, Davangere, Karnataka, India.
DEEPA PATIL Department of Pharmacology, BMCH, Chitradurga, Karnataka, India.
SATHISHA AITHAL Department of Pharmacology, K.V.G Medical College and Hospital, Sullia, Karnataka, India.
APOORVA BM Department of Pharmacology, JJMMC, Davangere, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i8.47738

Keywords:

Alternanthera sessilis, thrombocytopenia, albino rats, dengue fever

Abstract

Objectives of Study: (1) To determine the platelet augmenting effect on drug-induced thrombocytopenia in rats. (2) To observe any adverse effects and mortality in the animals.

Methods: Albino rats of either sex of average weight 150–200 g are used. A total of 36 (n=36) rats were divided into VI groups of 6 each. Groups I, II, III received cyclophosphamide 25 mg/kg body weight and group IV, V, VI received 50 mg/kg body weight for 3 consecutive days respectively. Blood was withdrawn from the retro-orbital plexus on the 1st, 4th, 7th, and 11th day of study after subjecting the animals to light anesthesia using ether and platelet count determined by making peripheral smear [8].

Results: Platelet count: Alternanthera sessilis leaves aqueous extract at concentrations of 200 mg/kg and 400 mg/kg were found to significantly increase the platelet count in cyclophosphamide-induced rat model.

Conclusion: The present study demonstrated the platelet augmenting effect of A. sessilis leaves aqueous extract. Further detailed studies are required to establish its usefulness.

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Author Biographies

DEEPA PATIL, Department of Pharmacology, BMCH, Chitradurga, Karnataka, India.

Basaveshwara medical college and hospital, SJMIT campus

NH-4 Bypass, Chitradurga, Karnataka

SATHISHA AITHAL, Department of Pharmacology, K.V.G Medical College and Hospital, Sullia, Karnataka, India.

Department of Pharmacology, K.V.G Medical College & Hospital, Sullia, Karnataka

APOORVA BM, Department of Pharmacology, JJMMC, Davangere, Karnataka, India.

DEPARTMENT OF PHARMACOLOGY,

J.J.M MEDICAL COLLEGE

DAVANGERE, KARNATAKA

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