COMPARISON OF PLAIN X-RAY WITH MRI IN PATIENTS OF RHEUMATOID ARTHRITIS AND SERONEGATIVE ARTHRITIS

Authors

  • bhagwan yadav Department of Radiodiagnosis, Government Medical College and Rajindra Hospital, Patiala, Punjab, India. https://orcid.org/0009-0002-1270-4120
  • Sulabh Puri Department of Radiodiagnosis, Government Medical College and Rajindra Hospital, Patiala, Punjab, India. https://orcid.org/0009-0003-3534-6618
  • Manoj Mathur Department of Radiodiagnosis, Government Medical College and Rajindra Hospital, Patiala, Punjab, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i10.47861

Keywords:

X ray, MRI, Seropositive, Seronegative, Arthritis

Abstract

Objective: The aim of this study was to compare the findings of plain X-ray with magnetic resonance imaging (MRI) in patients of rheumatoid arthritis and seronegative arthritis.

Methods: A total of 35 patients who apparently fulfilled the clinical diagnostic criteria were included on the basis of serological tests for seropositive and seronegative arthritis. After fulfillment of all the inclusion and exclusion criteria, radiographic images and MRI of joints were done by various MR techniques. Findings of plain radiography and MRI in various cases were compiled and subjected to statistical analysis using IBM software SPSS v20.

Results: Twenty-one patients were diagnosed with seropositive arthritis and 14 were with seronegative arthritis. The findings showed that MRI was 100 accurate in diagnosing seropositive and seronegative arthritis while the accuracy of X-ray in detecting seropositive arthritis (in comparison to MRI) was 62.86% with sensitivity of 38.1%, specificity of 100%, positive predictive value (PPV) of 100%, and negative predictive value (NPV) of 51.85%. The accuracy of X-ray in detecting seronegative arthritis (in comparison to MRI) was 85.71% with a sensitivity of 64.29%, specificity of 100%, PPV of 100%, and NPV of 80.77%.

Conclusion: MRI of seropositive and seronegative arthritis is a highly rewarding investigation and should be undertaken in all cases where plain radiographs are positive and when there is clinical suspicion of a disease but the X-ray films are not diagnostic.

Downloads

Download data is not yet available.

References

Zaid A, Gérardin P, Taylor A, Mostafavi H, Malvy D, Mahalingam S. Chikungunya arthritis: Implications of acute and chronic inflammation mechanisms on disease management. Arthritis Rheumatol 2018;70:484-95. doi: 10.1002/art.40403, PMID 29287308

Xu Y, Chen F. Acid-sensing ion Channel-1a in articular chondrocytes and synovial fibroblasts: A novel therapeutic target for rheumatoid arthritis. Front Immunol 2020;11:580936. doi: 10.3389/fimmu.2020.580936, PMID 33584647

Kumari R, Saharawat S. Effectiveness of dynamic metacarpophalangeal splint in treatment of ulnar deviation of rheumatoid arthritis on pinch strength and functional ability in women. J Prosthet Orthot 2022;10:1097.

Sahatçiu-Meka V, Rexhepi S, Manxhuka-Kërliu S, Rexhepi M. Radiographic estimation in seropositive and seronegative rheumatoid arthritis. Bosn J Basic Med Sci 2011;11:180-4. doi: 10.17305/ bjbms.2011.2571, PMID 21875421

Clarke EA, Watson P, Freeston JE, Peckham DG, Jones AM, Horsley A. Assessing arthritis in the context of cystic fibrosis. Pediatr Pulmonol 2019;54:770-7. doi: 10.1002/ppul.24290, PMID 30838784

Llopis E, Kroon HM, Acosta J, Bloem JL. Conventional radiology in rheumatoid arthritis. Radiol Clin North Am 2017;55:917-41. doi: 10.1016/j.rcl.2017.04.002, PMID 28774455

Brown JH, Deluca SA. The radiology of rheumatoid arthritis. Am Fam Phys 1995;52:1372-80. PMID 7572560

Mathiessen A, Conaghan PG. Synovitis in osteoarthritis: Current understanding with therapeutic implications. Arthritis Res Ther 2017;19:18. doi: 10.1186/s13075-017-1229-9, PMID 28148295

Nordberg LB, Lillegraven S, Aga AB, Sexton J, Olsen IC, Lie E, et al. Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/ EULAR classification criteria in a treat-to-target setting: 2-year data from the Arctic trial. RMD Open 2018;4:e000752. doi: 10.1136/ rmdopen-2018-000752, PMID 30564452

Østergaard M, Pedersen SJ, Døhn UM. Imaging in rheumatoid arthritis-status and recent advances for magnetic resonance imaging, ultrasonography, computed tomography and conventional radiography. Best Pract Res Clin Rheumatol 2008;22:1019-44. doi: 10.1016/j. berh.2008.09.014, PMID 19041075

Pratt AG, Isaacs JD. Seronegative rheumatoid arthritis: Pathogenetic and therapeutic aspects. Best Pract Res Clin Rheumatol 2014;28:651-9. doi: 10.1016/j.berh.2014.10.016, PMID 25481556

Tant L, Steinfeld S. Anti-CCP antibody test: Diagnostic and prognostic values in rheumatoid arthritis. Rev Med Brux 2006;27:55-98.

Burns TM, Calin A. The hand radiograph as a diagnostic discriminant between seropositive and seronegative “rheumatoid arthritis”: A controlled study “rheumatoid arthritis”: A controlled study. Ann Rheum Dis 1983;42:605-12. doi: 10.1136/ard.42.6.605, PMID 6651364

El-Khoury GY, Larson RK, Kathol MH, Berbaum KS, Furst DE. Seronegative and seropositive rheumatoid arthritis: Radiographic differences. Radiology 1988;168:517-20. doi: 10.1148/ radiology.168.2.3393674, PMID 3393674

Krahe T, Harder T, Mattern H, Leiendecker U. Follow-up study in chronic polyarthritis as represented in roentgen image. Rofo 1987;147:271-8. doi: 10.1055/s-2008-1048638, PMID 2823331

Gadeholt O, Hausotter K, Eberle H, Klink T, Pfeil A. Differing X-ray patterns in seronegative and seropositive rheumatoid arthritis. Clin Rheumatol 2019;38:2403-10. doi: 10.1007/s10067-019-04602-5, PMID 31123977

Paalanen K, Rannio K, Rannio T, Asikainen J, Hannonen P, Sokka T. Does early seronegative arthritis develop into rheumatoid arthritis A 10-year observational study. Clin Exp Rheumatol 2019;37:37-43. PMID 29998832

Santos-Moreno P, Alvis-Zakzuk NJ, Castillo E, Villarreal L, Pineda C, Sandoval H, et al. Quantifying potential cost-savings through an alternative imaging-based diagnostic process in presumptive seronegative rheumatoid arthritis. Clinicoecon Outcomes Res 2021;13:519-29. doi: 10.2147/CEOR.S302404, PMID 34168469

McQueen FM, Benton N, Crabbe J, Robinson E, Yeoman S, McLean L, et al. What is the fate of erosions in early rheumatoid arthritis Tracking individual lesions using x rays and magnetic resonance imaging over the first two years of disease. Ann Rheum Dis 2001;60:859-68. PMID 11502613

Published

07-10-2023

How to Cite

yadav, bhagwan, S. Puri, and M. Mathur. “COMPARISON OF PLAIN X-RAY WITH MRI IN PATIENTS OF RHEUMATOID ARTHRITIS AND SERONEGATIVE ARTHRITIS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 16, no. 10, Oct. 2023, pp. 84-88, doi:10.22159/ajpcr.2023.v16i10.47861.

Issue

Section

Original Article(s)