A STUDY OF SPECTRUM OF NEOPLASTIC AND NON-NEOPLASTIC LESIONS OF SALIVARY GLAND AND THEIR CYTOLOGICAL CORRELATION WITH HISTOPATHOLOGY

P NEERAJA; C LAKSHMI KALAVATHI; C BHAKTHAVATSALA REDDY

doi:10.22159/ajpcr.2023.v16i5.47896

Authors

P NEERAJA Department of Pathology A. C. Subba Reddy Government Medical College, Nellore, Andhra Pradesh, India.
C LAKSHMI KALAVATHI Department of Pathology A. C. Subba Reddy Government Medical College, Nellore, Andhra Pradesh, India.
C BHAKTHAVATSALA REDDY Department of Cardiology, Narayana Medical College and Hospitals, Nellore, Andhra Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i5.47896

Keywords:

Salivary gland tumors, Histopathology, Fine-needle aspiration cytology, pleomorphic adenoma

Abstract

Objective: This current study analyzed the diagnostic accuracy of cytology of various salivary gland lesions and correlated with histopathological findings.

Method: A study of 45 samples for fine-needle aspiration cytology (FNAC) were obtained from patients who were posted to the department of pathology. Aspirate from all salivary gland lesions and corresponding histopathological (HPE) specimens were included.

Results: Cytologic (FNAC) diagnosis reveals non-neoplastic, benign, and malignant lesions in 23% (12), 68% (31), and 4% (2) of 45 samples, respectively. While histopathological (HPE) diagnosis revealed non-neoplastic, benign, and malignant lesions in 20% (9), 62% (28), and 18% (8) of cases, respectively. The most common lesion in cytology and histology was discovered to be pleomorphic adenoma, which has a high sensitivity and specificity and can thus be used to screen all salivary gland tumors for a better therapeutic approach. The higher sensitivity, specificity, and diagnostic accuracy of FNAC confirms its important role in conjunction with radiological and clinical findings to provide the best initial assessment. There is a statistically significant relationship between the consistency, location, and cellularity of the lesion in benign and malignant tumours. Study concluded that on FNAC, 48% were benign in nature and 24% were malignant in nature. The sensitivity of FNAC was 86.5%, specificity was 100%, positive predictive value was 100%, negative predictive value was 86%, and diagnostic accuracy was 92.5%.

Conclusion: The study confirms the utility of FNAC as a safe and cost-effective method of distinguishing benign and malignant salivary gland lesions. FNAC had a sensitivity of 86.5%, a specificity of 100%, a positive predictive value of 100%, a negative predictive value of 86%, and a diagnostic accuracy of 92.75%. FNAC and histopathology complemented each other to provide infallible diagnoses that are critical in planning future management.

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References

Venkatesh S, Srinivas T, Hariprasad S. Parotid gland tumors: 2-year prospective clinicopathological study. Ann Maxillofac Surg 2019;9:103-9.

Sarkar D, Fisher PB. AEG-1/MTDH/Lyric: Clinical significance. Adv Cancer Res 2013;120:39-74.

Aggarwal A, Singh R, Sheikh S, Pallagatti S, Singla I. Pleomorphic adenoma of minor salivary gland: A case report. Rev Sul Bras Odontol 2012;9:97-101.

Tessy PJ, Jayalekshmy PS, Cicy PJ, Poothiode U. Fine needle aspiration cytology of salivary gland lesions with histopathological correlation: A two year study. Int J Healthc Biomed Res 2015;3:91-9.

Chi AC, Day TA, Neville BW. Oral cavity and oropharyngeal squamous cell carcinoma--an update. CA Cancer J Clin 2015;65:401-21.

Majchrzak E, Szybiak B, Wegner A, Pienkowski P, Pazdrowski J, Luczewski L, et al. Oral cavity and oropharyngeal squamous cell carcinoma in young adults: A review of the literature. Radiol Oncol 2014;48:1-10.

Baba AI, Câtoi C. Comparative oncology. In: Cancer Diagnosis. Ch. 18. Bucharest: The Publishing House of the Romanian Academy; 2007. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9550

Iacob A, Zazgyva A, Ormenişan A, Mezei T, Sin A, Tilinca M. Effectiveness of fine-needle aspiration cytology in the diagnosis of lateral cervical nonthyroid tumors. Medicine (Baltimore) 2016;95:e4448.

Gupta R, Dewan D, Kumar D, Suri J. Fine needle aspiration cytology (FNAC) of salivary gland lesions with histopathological correlation in a district hospital of Jammu region. Indian J Pathol Oncol 2016;3:32-7.

Gillani M, Akhtar F, Ali Z, Naz I, Atique M, Khadim MT. Diagnostic accuracy, sensitivity, specificity and positive predictive value of fine needle aspiration cytology (FNAC) in intra oral tumors. Asian Pac J Cancer Prev 2012;13:3611-5.

Deng FM, Hsu J, Khurana KK. Transmucosal fine needle aspiration of oral and pharyngeal lesions. Int Sch Res 2011;2011:1-7.

Stewart CJ, MacKenzie K, McGarry GW, Mowat A. Fine-needle aspiration cytology of salivary gland: A review of 341 cases. Diagn Cytopathol 2000;22:139-46.

AlGhamdi GZ, Alzahrani AK, Saati H, Algarni HM, Alshehri KA, Baroom M, et al. Correlation between fine needle aspiration cytology (FNAC) and permanent histopathology results in salivary gland masses. Cureus 2021;13:e13976.

Verma S. Fine needle aspiration cytology of salivary gland lesions: Study in a tertiary care hospital of North Bihar. Int J Res Med Sci 2016;4:3869-72.

Shalley S, Chand N, Aggarwal A, Garg LN, Yadav V, Yadav A. Diagnostic accuracy of fine needle aspiration cytology in lesions of oral cavity and salivary glands: A clinico-pathological study. Open Dent J 2018;12:782-90.

Stow N, Veivers D, Poole A. Fine-needle aspiration cytology in the management of salivary gland tumors: An Australian experience. Ear Nose Throat J 2004;83:128-31.

Kakoty S, Baruah TD, Babu CP. FNAC and histopathological correlation of salivary gland lesions: An observational study. Int J Surg 2017;4:2148-52.

Sharma M, Bala N, Angral S. FNAC of salivary gland lesions with histopathological correlation. Int J Oral Health Med Res 2015;2:8-12.

Vaidya S, Sinha A, Narayan S, Adhikari S, Sabira KC. A comparative study of fine-needle aspiration cytology and histopathology in salivary gland lesions. J Pathol Nepal 2011;1:108-13.

Dhanani R, Iftikhar H, Awan MS, Zahid N, Momin SN. Role of fine needle aspiration cytology in the diagnosis of parotid gland tumors: Analysis of 193 cases. Int Arch Otorhinolaryngol 2020;24:e508-12.

Sahni S, Vijay Shankar S, Krishnappa A. Diagnostic efficacy of fine needle aspiration cytology in cystic lesions of head and neck region- A single experience at tertiary health care centre. Natl J Lab Med 2017;6:PO01-7.

Mihashi H, Kawahara A, Kage M, Kojiro M, Nakashima T, Umeno H, et al. Comparison of preoperative fine-needle aspiration cytology diagnosis and histopathological diagnosis of salivary gland tumors. Kurume Med J 2006;53:23-7.

Yogambal M, Chandramouleeswari K, Marylilly SA. Role of fine needle aspiration cytology in salivary gland pathology and its histopathological correlation: A five year descriptive study in a tertiary care centre. Online J Otolaryngol 2015;5:54.

Ramana SV, Sudhasree Y. A Cytopathological study of salivary gland lesions with histopathological correlation tertiary care center. MedPulse Int J Pathol 2017;4:32-4.