PSYCHOMOTOR RECOVERY AFTER INTRAVENOUS DEXMEDETOMIDINE INFUSION AS A PART OF BALANCED ANAESTHESIA – AN OBSERVATIONAL STUDY
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i4.47911Keywords:
Balanced anesthesia, Dexmedetomidine, Psychomotor recovery, Trieger dot, Digit symbol substitutionAbstract
Objective: The aim of the study was to determine the recovery of psychomotor function from balanced anesthesia with and without intravenous (IV) dexmedetomidine infusion as an adjunct.
Methods: A prospective and observational study was conducted in a tertiary care teaching hospital for 12 months. A total of 170 patients (American Society of Anaesthesiologists 1 and 2) in the age group of 18–50 years scheduled for elective surgery under general anesthesia with an anticipated duration of <3 h received either dexmedetomidine infusion (Group D) or not (Group S). Recovery of psychomotor function postoperatively was assessed with trieger dot test (TDT), digit symbol substitution test (DSST), and intraoperative fentanyl requirement in both groups. Data collected were analyzed using SPSS version 16.
Results: Both groups were comparable with respect to demographic variables. Psychomotor recovery assessed by TDT showed statistically significant early recovery in Group D compared with Group S. This was seen in the number of dots missed, maximum distance of dots missed as well as in the average distance of dots missed at post-operative time intervals of 30 min, 60 min, 90 min, and 120 min. Similarly, DSST revealed early recovery at these time points. There was a significant decrease in the intraoperative fentanyl requirement in Group D compared with Group S.
Conclusion: The addition of dexmedetomidine to the balanced anesthetic technique significantly hastened the psychomotor recovery.
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Mishra SK, Chandrasekaran A, Parida S, Senthilnathan M, Bidkar PU, Gupta SL. Time course of psychomotor recovery after intravenous dexmedetomidine infusion as a part of balanced anaesthetic technique: A randomized, double-blind study. Indian J Anaesth 2019;63:623-8. doi: 10.4103/ija.IJA_192_19, PMID 31462807
Arain SR, Ruehlow RM, Uhrich TD, Ebert TJ. The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery. Anesth Analg 2004;98:153-8. doi: 10.1213/01. ANE.0000093225.39866.75, PMID 14693611
Ohtani N, Kida K, Shoji K, Yasui Y, Masaki E. Recovery profiles from dexmedetomidine as a general anesthetic adjuvant in patients undergoing lower abdominal surgery. Anesth Analg 2008;107:1871-4. doi: 10.1213/ane.0b013e3181887fcc, PMID 19020132
Lee YY, Wong SM, Hung CT. Dexmedetomidine infusion as a supplement to isoflurane anaesthesia for vitreoretinal surgery. Br J Anaesth 2007;98:477-83. doi: 10.1093/bja/aem040, PMID 17332003
Shin HW, Yoo HN, Kim DH, Lee H, Shin HJ, Lee HW. Preanesthetic dexmedetomidine 1 μg/kg single infusion is a simple, easy, and economic adjuvant for general anesthesia. Korean J Anesthsiol 2013;65:114-20. doi: 10.4097/kjae.2013.65.2.114, PMID 24023992
Patel CR, Engineer SR, Shah BJ, Madhu S. The effect of dexmedetomidine continuous infusion as an adjuvant to general anesthesia on sevoflurane requirements: A study based on entropy analysis. J Anaesthesiol Clin Pharmacol 2013;29:318-22. doi: 10.4103/0970-9185.117066, PMID 24106354
Newman MG, Trieger N, Miller JC. Measuring recovery from anesthesia-a simple test. Anesth Analg 1969;48:136-40. doi: 10.1213/00000539-196901000-00028, PMID 5812547
Takayama A, Yamaguchi S, Ishikawa K, Shinozaki M, Kimura Y, Nagao M, et al. Recovery of psychomotor function after total intravenous anesthesia with remifentanil-propofol or fentanyl- propofol. J Anesth 2012;26:34-8. doi: 10.1007/s00540-011-1266-5, PMID 22048284
Ding L, Zhang H, Mi W, Wang T, He Y, Zhang X, et al. Effects of dexmedetomidine on anesthesia recovery period and postoperative cognitive function of patients after robot-assisted laparoscopic radical cystectomy. Int J Clin Exp Med 2015;8:11388-95. PMID 26379954
Cheung CW, Ng KF, Liu J, Yuen MY, Ho MH, Irwin MG. Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia. Br J Anaesth 2011;107:430-7. doi: 10.1093/ bja/aer164, PMID 21685111
Arain SR, Ebert TJ. The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation. Anesth Analg 2002;95:461-6. doi: 10.1097/00000539-200208000-00042, PMID 12145072
Hall JE, Uhrich TD, Barney JA, Arain SR, Ebert TJ. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions. Anesth Analg 2000;90:699-705. doi: 10.1097/00000539-200003000- 00035, PMID 10702460
Bajwa SJ, Kaur J, Singh A, Parmar S, Singh G, Kulshrestha A, et al. Attenuation of pressor response and dose sparing of opioids and anaesthetics with pre-operative dexmedetomidine. Indan J Anaesth 2012;56:123-8. doi: 10.4103/0019-5049.96303, PMID 22701201
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