SYMPTOMATOLOGY FOLLOWING COVID-19 VACCINATION – A CROSS-SECTIONAL STUDY IN CENTRAL INDIA
DOI:
https://doi.org/10.22159/ajpcr.2023v16i9.47941Keywords:
Covid-19 disease, Covid-19 vaccine, post-vaccination symptomsAbstract
Objective: A successful COVID-19 vaccine should survive the safety, efficacy, and potency testing phases without causing any negative side effects, especially in high-risk individuals, such as the elderly, pregnant women, people with comorbidities, health-care workers, and others. The present study was conducted to determine common symptoms following the COVID-19 vaccine, the intensity of symptoms after the first and second doses, and estimate the prevalence of acquiring COVID-19 infection after getting vaccinated with the COVID-19 vaccine.
Methods: An observational cross-sectional study was conducted in the rural field practice area, including 445 participants from 19 villages. The statistical analysis was done using Microsoft Excel, and the data were represented in frequency and graphs.
Results: In the present study, the maximum (74%) of participants were Covishield recipients. The top three symptoms experienced after the first dose were headache (189), fever (130), and pain in the arm at which the vaccine was given (77). After the second dose, the top three symptoms were fever (281), headache (137), and fatigue (73). The top three psychosomatic symptoms were increased sleep (162), decreased sleep (122), and the third ranker was anxiety (93). More participants reported having severe symptoms after the first dose than after the second. Three percent of research participants contracted COVID-19 infection after the first dose, and 2% after the second.
Conclusion: Fever and headache were common symptoms after the first and second doses, but symptoms were more severe after administration of the first dose of the COVID-19 vaccine. Following vaccination, COVID-19 infection was extremely rare among participants.
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References
Clark R. Business Continuity and the Pandemic Threat. England: IT Governance Ltd; 2016.
Yatoo MI, Hamid Z, Parray OR, Wani AH, Ul Haq A, Saxena A, et al. COVID-19-Recent advancements in identifying novel vaccine candidates and current status of upcoming SARS-CoV-2 vaccines. Hum Vaccin Immunother 2020;16:1-14. doi: 10.1080/21645515.2020.1788310 3. Sharun K, Tiwari R, Patel SK, Karthik K, Yatoo MI, Malik YS, et al. Coronavirus disease 2019 (COVID-19) in domestic animals and wildlife: Advances and prospects in the development of animal models for vaccine and therapeutic research. Hum Vaccin Immunother 2020e;16:3043-54. doi: 10.1080/21645515.2020.1807802
Yaqub O, Castle-Clarke S, Sevdalis N, Chataway J. Attitudes to vaccination: A critical review. Soc Sci Med 2014;112:1-11. https://doi.org/10.1016/j.socscimed.2014.04.018
Dubé E, MacDonald NE. Vaccine acceptance: Barriers, perceived risks, benefits, and irrational beliefs. In: The Vaccine book. United States: Academic Press; 2016. p. 507-28.
World’s Largest Vaccination Programme Begins in India on January 16. The Hindu; 2021. Available from: https://www.thehindu.com/ news/national/coronavirus-worlds-largest-vaccination-programme-begins-in-india-on-january-16/article33582069.ece#:~:text=A%20 health%20official%20shows%20a,30%20a.m.%20via%20video%20 conferencing [Last accessed on 2023 May 04].
State-Wise Vaccination. Ministry of Health and Family Welfare. Available from: https://www.mohfw.gov.in/pdf/ COVID19VaccineOG111Chapter16.pdf. [Last accessed on 2021 May 04].
Lwanga SK, Lemeshow S. Sample Size Determination in Health Studies, A practical Manual. Geneva: World Health Organization; 1991. p. 1-3.
Menni C, Klaser K, May A, Polidori L, Capdevila J, Louca P, et al. Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study. The Lancet Infectious Diseases, 21(7), 939–949. https://doi.org/10.1016/s1473-3099(21)00224-3.
Goldman RD, Yan TD, Seiler M, Cotanda CP, Brown JC, Klein EJ, et al. Caregiver willingness to vaccinate their children against COVID-19: Cross sectional survey. Vaccine 2020;38:7668-3.
Zhang KC, Fang Y, Cao HE, Chen H, Hu T, Chen YQ, et al. Parental acceptability of COVID-19 vaccination for children under the age of 18 years: Cross-sectional online survey. JMIR Pediatr Parent 2020;3:e24827.
AlHajri B, Alenezi D, Alfouzan H, Altamimi S, Alzalzalah S, Almansouri W, et al. Willingness of parents to vaccinate their children against influenza and the novel coronavirus disease-2019. J Pediatr 2021;231:298-99.
Bell S, Clarke R, Mounier-Jack S, Walker JL, Paterson P. Parents’ and guardians’ views on the acceptability of a future COVID-19 vaccine: A multi-methods study in England. Vaccine 2020;38:7789-98.
Patrick, S. W., Henkhaus, L. E., Zickafoose, J. S., Lovell, K., Halvorson, A., Loch, S., Letterie, M., & Davis, M. M. (2020, July 24). Well-being of Parents and Children During the COVID-19 Pandemic: A National Survey. Pediatrics, 146(4), e2020016824. https://doi.org/10.1542/ peds.2020-016824.
Goldman RD, Marneni SR, Seiler M, Brown JC, Klein EJ, Cotanda CP, et al. Caregivers’ willingness to accept expedited vaccine research during the COVID-19 pandemic: A cross-sectional survey. Clin Ther 2020;42:2124-33.
Hetherington E, Edwards SA, MacDonald SE, Racine N, Madigan S, McDonald S, Tough S. SARS-CoV-2 vaccination intentions among mothers of children aged 9 to 12 years: a survey of the All Our Families cohort. CMAJ Open. 2021 May 21;9(2):E548-E555. doi: 10.9778/ cmajo.20200302. Erratum in: CMAJ Open. 2021 Jul 27;9(3):E795. PMID: 34021012; PMCID: PMC8177949.
Yigit M, Ozkaya-Parlakay A, Senel E. Evaluation of COVID-19 vaccine refusal in parents. Pediatr Infect Dis J 2021;40 e134-6.
Yilmazbaş NP, Terzi O, Ozceker D. Did covid-19 pandemic changed parents’ approach to vaccination? Erciyes Med J 2020;43;130-4.
Yilmaz M, Sahin MK. Parents’ willingness and attitudes concerning the COVID-19 vaccine: A cross-sectional study. Int J Clin Pract 2021;75:e14364. https://doi.org/10.1111/ijcp.14364
Ganesan S, Al Ketbi LM, Al Kaabi N, Al Mansoori M, Al Maskari NN, Al Shamsi MS, et al. Vaccine side effects following COVID-19 vaccination among the residents of the uae-an observational study. Front Public Health 2022;10:876336. doi: 10.3389/fpubh.2022.876336
Saeed BQ, Al-Shahrabi R, Alhaj SS, Alkokhardi ZM, Adrees AO. Side effects and perceptions following sinopharm COVID-19 vaccination. Int J Infect Dis 2021;111:219-26. https://doi.org/10.1016/j.ijid.2021.08.013
Bareiß A, Uzun G, Mikus M, Becker M, Althaus K, Schneiderhan- Marra N, et al. Vaccine side effects in health care workers after vaccination against SARS-CoV-2: Data from TüSeRe: exact study. Viruses 2023;15:65. https://doi.org/10.3390/v15010065
Ruiz-Quiñones JA, Narváez-Osorio VM, Ulín-Tejeda OA, Flores- Barrientos OI, Suárez-Méndez S, Baeza-Flores GD, et al. Side effects of the Pfizer BioNTech vaccine J Infect Dev Ctries 2022;16:1413-6. doi:10.3855/jidc.15545
Singh A, Khillan R, Mishra Y, Khurana S. The safety profile of COVID-19 vaccinations in the United States. Am J Infect Control 2022;50:15-9. https://doi.org/10.1016/j.ajic.2021.10.015
Oğuz SH, Şendur SN, İremli BC, Gürlek A, Erbas T, Ünlütürk U. SARS-CoV-2 vaccine-induced thyroiditis: Safety of revaccinations and clinical follow-up. J Clin Endocrinol Metab 2022;107:e1823-34. https://doi.org/10.1210/clinem/dgac049
Onyango J, Mukunya D, Napyo A, Nantale R, Makoko BT, Matovu JK, et al. Side-effects following Oxford/AstraZeneca COVID-19 vaccine in Tororo district, Eastern Uganda: A cross-sectional study. Int J Environ Res Public Health 2022;19:15303. https://doi.org/10.3390/ ijerph1922153030
Desalegn M, Garoma G, Tamrat H, Desta A, Prakash A. The prevalence of AstraZeneca COVID-19 vaccine side effects among Nigist Eleni Mohammed memorial comprehensive specialized hospital health workers. Cross sectional survey. PLoS One 2022;17:e0265140. https:// doi.org/10.1371/journal.pone.0265140
Sv P, Tandon J, Vikas, Hinduja H. Indian citizen’s perspective about side effects of COVID-19 vaccine - A machine learning study. Diabetes Metab Syndr. 2021 Jul-Aug;15(4):102172. doi: 10.1016/j. dsx.2021.06.009. Epub 2021 Jun 10. PMID: 34186350; PMCID: PMC8189737.
Pokharel K, Dawadi BR, Karki A. Side effects after second dose of covishield vaccine among healthcare workers: A descriptive cross-sectional study. JNMA J Nepal Med Assoc 2021;59:577-9.
Amit S, Beni SA, Biber A, Grinberg A, Leshem E, Regev-Yochay G. Postvaccination COVID-19 among healthcare workers, Israel. Emerg Infect Dis 2021;27:1220-2.
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