EMERGING AND RE-EMERGING BACTERIAL ZOONOSES SCREENING OF HIGH RISK GROUPS FOR LEPTOSPIRAL SEROVARS
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i10.47942Keywords:
Bacterial Zoonoses, Leptopsirosis, SeroprevalenceAbstract
Objective: To collect information related to leptospirosis among high-risk groups: agricultural workers, butchers, construction workers, and hospital sanitary workers through questionnaires and to determine the presence of leptospires among these high-risk groups (both genus and serovarspecific).
Methods: A total of 367 eligible subjects were included (112 agricultural workers, 108 construction site workers, 89 sanitary workers, and 58 butchers).
Results: The genus-specific enzyme-linked immunosorbent assay was performed for all the serum samples (n=367) and showed reactiveness among 149 subjects. The results were compared with the serovar-specific microscopic agglutination test, which showed positivity in 158 subjects.
Conclusion: Screening the occupational risk group for the presence of leptopsiral prints in order to provide appropriate medical check-ups and the earliest treatment. An educational program for rodent control and infection control where the seroprevalence is high should be organized.
Downloads
References
Adler B, Faine S, Gordon LM. The enzyme-linked immunosorbent assay (ELISA) as a serological test for detecting antibodies against Leptospira interrogans serovar hardjo in sheep. Aust Vet J 1981;57:414- 7. doi: 10.1111/j.1751-0813.1981.tb00546.x, PMID 7034708
Goris MG, Boer KR, Duarte TA, Kliffen SJ, Hartskeerl RA. Human leptospirosis trends, the Netherlands, 1925–2008. Emerg Infect Dis 2013;19:371-8. doi: 10.3201/eid1903.111260, PMID 23622144
Adler B, Faine S. The antibodies involved in the human immune response to leptospiral infection. J Med Microbiol 1978;11:387-400. doi: 10.1099/00222615-11-4-387, PMID 722781
Ko AI, Galvão Reis M, Ribeiro Dourado CM, Johnson WD Jr., Riley LW. Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study Group. Lancet 1999;354:820-5. doi: 10.1016/ s0140-6736(99)80012-9, PMID 10485724
Prabhusaran N, Natarajaseenivasan K, Joseph PI. In vitro determination of 5-fluorouracil as a selective agent for leptospiral culture medium. Int J Sci Clin Invent 2017;4:3311-3.
Raagavendhar VB, Prabhusaran N, Uma A, Hemalatha K, Natarajaseenivasan K, Joseph PI. Prevalence of leptospirosis among rice mill workers in Tiruchirapalli, South India. Ann Int Med Dent Res 2019;5:6-13.
Christmas BW, Tennent RB, Lindsay PG. Dairy farm fever in New Zealand: A local outbreak of human leptospirosis. N Z Med J 1974;79:901-4. PMID 4527727
Nascimento AL, Ko AI, Martins EA, Monteiro-Vitorello CB, Ho PL, Haake DA, et al. Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis. J Bacteriol 2004;186:2164-72. doi: 10.1128/JB.186.7.2164-2172.2004, PMID 15028702
Abela-Ridder B, Sikkema R, Hartskeerl RA. Estimating the burden of human leptospirosis. Int J Antimicrob Agents 2010;36:S5-7.
Jayasundara D, Gamage C, Senavirathna I, Warnasekara J, Matthias MA, Vinetz JM, et al. Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of leptospirosis in a low resource, hyperendemic setting with varied microgeographic variation in reactivity. PLoS Negl Trop Dis 2021;15:e0009565.
Torgerson PR, Hagan JE, Costa F, Calcagno J, Kane M, Martinez- Silveira MS, et al. Global burden of leptospirosis: Estimated in terms of disability adjusted life years. PLoS Negl Trop Dis 2015;9:e0004122. doi: 10.1371/journal.pntd.0004122, PMID 26431366
Manikandan N, Prabhusaran N, Jeyaseelan ST, Uma A, Natarajaseenivasan K, Joseph PI. Seroprevalence of leptospiral antibodies among municipal service workers in Tiruchirapalli, South India. Innovations 2021;64:583-93.
Published
How to Cite
Issue
Section
Copyright (c) 2023 Prabhu Nagarajan, Clitus A, Anupriya A
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
