ASSOCIATION BETWEEN TYPE 2 DIABETES MELLITUS AND COVID-19 SEVERITY: A LITERATURE REVIEW
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i5.47961Keywords:
Diabetes, Infection, Coronavirus, COVID-19, SARS-CoV-2Abstract
Objective: Globally, there is a rise in the frequency of type 2 diabetes mellitus and diabetes is severe co-morbidity in COVID-19 patients. We conducted a review and evaluated the already documents reports for the relationship among diabetes and COVID-19.
Methods: Full text was retrieved using PubMed database and Google Scholar using the key phrases ‘COVID-19’, ‘SARS-CoV-2’, ‘diabetes’.
Results: The review outcome shows that the COVID-19 severity seems to be greater among patients with diabetes as comorbidity. So, strict glycemic control is imperative in patients infected with COVID-19.
Conclusions: Thus, world-wide diabetes burden and COVID-19 pandemic must be deliberated as diabetes increases the COVID-19 severity. Established on this, it is precise significant to follow specific treatment protocols and clinical management in COVID-19 patients affected with diabetes to prevent morbidity and mortality.
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Sharma A, Tiwari S, Deb MK, Marty JL. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): A global pandemic and treatment strategies. Int J Antimicrob Agents 2020;56:106054. doi: 10.1016/j.ijantimicag.2020.106054, PMID: 32534188; PMCID: PMC7286265
Wu YC, Chen CS, Chan YJ. The outbreak of COVID-19: An overview. J Chin Med Assoc 2020;83:217-20. doi: 10.1097/ JCMA.0000000000000270, PMID: 32134861; PMCID: PMC7153464
Hasan SS, Capstick T, Ahmed R, Kow CS, Mazhar F, Merchant HA, et al. Mortality in COVID-19 patients with acute respiratory distress syndrome and corticosteroids use: A systematic review and meta-analysis. Expert Rev Respir Med 2020;14:1149-63. doi: 10.1080/17476348.2020.1804365, PMID: 32734777; PMCID: PMC7544968
Guo W, Li M, Dong Y, Zhou H, Zhang Z, Tian C, et al. Diabetes is a risk factor for the progression and prognosis of COVID-19. Diabetes Metab Res Rev 2020;36:e3319.
Yang JK, Feng Y, Yuan MY, Yuan SY, Fu HJ, Wu BY, et al. Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS. Diabet Med 2006;23:623-8. doi: 10.1111/j.1464-5491.2006.01861.x
Wang Z, Du Z, Zhu F. Glycosylated hemoglobin is associated with systemic inflammation, hypercoagulability, and prognosis of COVID-19 patients. Diabetes Res Clin Pract 2020;164:108214. doi: 10.1016/j. diabres.2020.108214, PMID: 32416121; PMCID: PMC7233217
Eastin C, Eastin T. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;58:711-2. doi: 10.1056/ NEJMoa2002032. Guan W, Ni Z, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. J Emerg Med 2020;382:1708-20. doi: 10.1016/j.jemermed.2020.04.004; PMCID: PMC7266766
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497-506. doi: 10.1016/S0140-6736(20)30183-5. Erratum in: Lancet 2020. PMID: 31986264; PMCID: PMC7159299
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020;323:1061-9. doi: 10.1001/ jama.2020.1585. Erratum in: JAMA 2021;325:1113. PMID: 32031570; PMCID: PMC7042881
Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: A systematic review and meta-analysis. Int J Infect Dis 2020;94:91-5. doi: 10.1016/j.ijid.2020.03.017, PMID: 32173574; PMCID: PMC7194638
Chen Y, Gong X, Wang L, Jiao G. Effects of hypertension, diabetes and coronary heart disease on Covid-19 diseases severity: A systematic review and meta-analysis. medRxiv 2020:1-12. doi. org/10.1101/2020.03.25.20043133
Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for disease control and prevention. JAMA 2020;323:1239-42. doi: 10.1001/jama.2020.2648, PMID: 32091533
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet 2020;395:1054-62. doi: 10.1016/S0140-6736(20)30566-3. Erratum in: Lancet 2020;395:1038. PMID: 32171076; PMCID: PMC7270627
Singh AK, Gupta R, Misra A. Comorbidities in COVID-19: Outcomes in hypertensive cohort and controversies with renin angiotensin system blockers. Diabetes Metab Syndr 2020;14:283-7. doi: 10.1016/j. dsx.2020.03.016, PMID: 32283499; PMCID: PMC7144598
Epidemiology Working Group for NCIP Epidemic Response CC for DC and P. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Zhonghua Liu Xing Bing Xue Za Zhi 2020;41:145-51. doi: 10.3760/cma.j.is sn.0254-6450.2020.02.003, PMID: 32064853
Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA 2020;323:1775-6. doi: 10.1001/jama.2020.4683. Erratum in: JAMA 2020;323:1619. PMID: 32203977
Bhatraju PK, Ghassemieh BJ, Nichols M, Kim R, Jerome KR, Nalla AK, et al. Covid-19 in critically ill patients in the seattle region-case series. N Engl J Med 2020;382:2012-22. doi: 10.1056/NEJMoa2004500, PMID: 32227758; PMCID: PMC7143164
COVID-19 Surveillance Group. Characteristics of COVID-19 Patients Dying in Italy Report Based on Available Data on March 20th, 2020. COVID-19 Surveillance Group; 2020.
CDC COVID-19 Response Team. Preliminary estimates of the prevalence of selected underlying health conditions among patients with coronavirus disease 2019-United States, February 12-March 28, 2020. MMWR Morb Mortal Wkly Rep 2020;69:382-6. doi: 10.15585/ mmwr.mm6913e2, PMID: 32240123; PMCID: PMC7119513
Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med 2020;180:934-43. doi: 10.1001/jamainternmed.2020.0994. Erratum in: JAMA Intern Med 2020;180:1031. PMID: 32167524; PMCID: PMC7070509.
Wang T, Du Z, Zhu F, Cao Z, An Y, Gao Y, et al. Comorbidities and multi-organ injuries in the treatment of COVID-19. Lancet 2020;395:e52. doi: 10.1016/S0140-6736(20)30558-4, PMID: 32171074; PMCID: PMC7270177
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: Retrospective study. BMJ 2020;368:m1295. doi: 10.1136/ bmj.m1295. PMID: 32234718
Apicella M, Campopiano MC, Mantuano M, Mazoni L, Coppelli A, Del Prato S. COVID-19 in people with diabetes: Understanding the reasons for worse outcomes. Lancet Diabetes Endocrinol 2020;8:782- 92. doi: 10.1016/S2213-8587(20)30238-2. Erratum in: Lancet Diabetes Endocrinol 2020;8:e5. Erratum in: Lancet Diabetes Endocrinol 2020;8:e6. PMID: 32687793; PMCID: PMC7367664
Yang JK, Zhao MM, Jin JM, Liu S, Bai P, He W, et al. New-onset COVID-19-related diabetes: An early indicator of multi-organ injury and mortally of SARS-CoV-2 infection. Curr Med (Cham) 2022;1:6. doi: 10.1007/s44194-022-00006-x. PMID: 35673632; PMCID: PMC9132601
Li H, Tian S, Chen T, Cui Z, Shi N, Zhong X, et al. Newly diagnosed diabetes is associated with a higher risk of mortality than known diabetes in hospitalized patients with COVID-19. Diabetes Obes Metab 2020;22:1897-906. doi: 10.1111/dom.14099, PMID: 32469464; PMCID: PMC7283710
Wang S, Ma P, Zhang S, Song S, Wang Z, Ma Y, et al. Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: A multi-centre retrospective study. Diabetologia 2020;63:2102-11. doi: 10.1007/ s00125-020-05209-1, PMID: 32647915; PMCID: PMC7347402
Fadini GP, Morieri ML, Boscari F, Fioretto P, Maran A, Busetto L, et al. Newly-diagnosed diabetes and admission hyperglycemia predict COVID-19 severity by aggravating respiratory deterioration. Diabetes Res Clin Pract 2020;168:108374. doi: 10.1016/j.diabres.2020.108374, PMID: 32805345; PMCID: PMC7428425
World Health Organization. COVID-19 Significantly Impacts Health Services for Noncommunicable Diseases. Geneva: World Health Organization. Available from: https://wwwwhoint/news-room/ detail/01-06-2020-covid-19-significantly-impacts-health-services-for-noncommunicable-diseases
Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: A systematic overview. Lancet 2000;355:773-8. doi: 10.1016/S0140-6736(99)08415-9, PMID: 10711923
Coppelli A, Giannarelli R, Aragona M, Penno G, Falcone M, Tiseo G, et al. Hyperglycemia at hospital admission is associated with severity of the prognosis in patients hospitalized for COVID-19: The pisa COVID-19 study. Diabetes Care 2020;43:2345-8. doi: 10.2337/dc20- 1380, PMID: 32788285
Wilson C. Is covid-19 causing diabetes? New Sci 2022;254:14. doi: 10.1016/S0262-4079(22)00688-1. PMID: 35498156; PMCID: PMC9033286
White DL, Ratziu V, El-Serag HB. Hepatitis C infection and risk of diabetes: A systematic review and meta-analysis. J Hepatol 2008;49:831-44. doi: 10.1016/j.jhep.2008.08.006, PMID: 18814931; PMCID: PMC2642971
Kusmartseva I, Wu W, Syed F, Van Der Heide V, Jorgensen M, Joseph P, et al. Expression of SARS-CoV-2 entry factors in the pancreas of normal organ donors and individuals with COVID-19. Cell Metab 2020;32:1041-51.e6. doi: 10.1016/j.cmet.2020.11.005, PMID: 33207244; PMCID: PMC7664515
Monteil V, Kwon H, Prado P, Hagelkrüys A, Wimmer RA, Stahl M, et al. Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2. Cell 2020;181:905-13.e7. doi: 10.1016/j.cell.2020.04.004, PMID: 32333836; PMCID: PMC7181998
Roca-Ho H, Riera M, Palau V, Pascual J, Soler MJ. Characterization of ACE and ACE2 expression within different organs of the NOD mouse. Int J Mol Sci 2017;18:563. doi: 10.3390/ijms18030563, PMID: 28273875; PMCID: PMC5372579
Drucker DJ. Coronavirus infections and Type 2 diabetes-shared pathways with therapeutic implications. Endocr Rev 2020;41:bnaa011. doi: 10.1210/endrev/bnaa011. PMID: 32294179
Philips BJ, Meguer JX, Redman J, Baker EH. Factors determining the appearance of glucose in upper and lower respiratory tract secretions. Intensive Care Med 2003;29:2204-10. doi: 10.1007/s00134-003-1961- 2, PMID: 14647890
Kohio HP, Adamson AL. Glycolytic control of vacuolar-type ATPase activity: A mechanism to regulate influenza viral infection. Virology 2013;444:301-9. doi: 10.1016/j.virol.2013.06.026, PMID: 23876457
Reading PC, Allison J, Crouch EC, Anders EM. Increased susceptibility of diabetic mice to influenza virus infection: Compromise of collectin-mediated host defense of the lung by glucose? J Virol 1998;72:6884-7. doi: 10.1128/JVI.72.8.6884-6887.1998, PMID: 9658139
Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LF. The trinity of COVID-19: Immunity, inflammation and intervention. Nat Rev Immunol 2020;20:363-74. doi: 10.1038/s41577-020-0311-8, PMID: 32346093; PMCID: PMC7187672
Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol 2020;20(6):363-374. doi: 10.1038/s41577-020-0311-8. PMID: 32346093; PMCID: PMC7187672.
Kim JH, Park K, Lee SB, Kang S, Park JS, Ahn CW, et al. Relationship between natural killer cell activity and glucose control in patients with Type 2 diabetes and prediabetes. J Diabetes Investig 2019;10:1223-8.
Menart-Houtermans B, Rütter R, Nowotny B, Rosenbauer J, Koliaki C, Kahl S, et al. Leukocyte profiles differ between Type 1 and Type 2 diabetes and are associated with metabolic phenotypes: Results from the German Diabetes Study (GDS). Diabetes Care 2014;37:2326-33. doi: 10.2337/dc14-0316. PMID: 25061140
Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City Area. JAMA 2020;323:2052-9. doi: 10.1001/ jama.2020.6775. Erratum in: JAMA 2020;323:2098. PMID: 32320003; PMCID: PMC7177629
Darvishi-Khezri H, Alipour A, Zeydi AE, Firouzian A, Mahmudi G, Omrani-Nava M. Is Type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia? J Res Med Sci 2016;21:19. doi: 10.4103/1735- 1995.179887. PMID: 27904565; PMCID: PMC5121997
Anandhalakshmi S, Manikandan S, Ganeshkumar P, Ramachandran C. Alveolar gas exchange and pulmonary functions in patients with Type II diabetes mellitus. J Clin Diagn Res 2013;7:1874-7. doi: 10.7860/JCDR/2013/6550.3339. PMID: 24179886; PMCID: PMC3809625.874-7.
Chen IY, Moriyama M, Chang MF, Ichinohe T. Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome. Front Microbiol 2019;10:50. doi: 10.3389/fmicb.2019.00050. PMID: 30761102; PMCID: PMC6361828
Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet 2020;395:1417-8. doi: 10.1016/S0140- 6736(20)30937-5. PMID: 32325026; PMCID: PMC7172722
Short KR, Kroeze EJ, Fouchier RA, Kuiken T. Pathogenesis of influenza-induced acute respiratory distress syndrome. Lancet Infect Dis 2014;14:57-69. doi: 10.1016/S1473-3099(13)70286-X. PMID: 24239327
Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 2020;18:844-7. doi: 10.1111/jth.14768. PMID: 32073213; PMCID: PMC7166509
Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost 2020;18:1421-4. doi: 10.1111/ jth.14830. PMID: 32271988; PMCID: PMC7262324
Antoniak S. The coagulation system in host defense. Res Pract Thromb Haemost 2018;2:549-57. doi: 10.1002/rth2.12109. PMID: 30046760; PMCID: PMC6046589
Stegenga ME, Van der Crabben SN, Blümer RM, Levi M, Meijers JC, Serlie MJ, et al. Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia. Blood 2008;112:82-9. doi: 10.1182/ blood-2007-11-121723. PMID: 18316629; PMCID: PMC2435690
Ibrahim S, Lowe JR, Bramante CT, Shah S, Klatt NR, Sherwood N, et al. Metformin and Covid-19: Focused review of mechanisms and current literature suggesting benefit. Front Endocrinol (Lausanne) 2021;12:587801. doi: 10.3389/fendo.2021.587801, PMID: 34367059; PMCID: PMC8342037
Li J, Wei Q, Li WX, McCowen KC, Xiong W, Liu J, et al. Metformin use in diabetes prior to hospitalization: Effects on mortality in Covid-19. Endocr Pract 2020;26:1166-72. doi: 10.4158/EP-2020-0466. PMID: 33471718; PMCID: PMC7834011
Cheng X, Liu YM, Li H, Zhang X, Lei F, Qin JJ, et al. Metformin is associated with higher incidence of acidosis, but not mortality, in individuals with COVID-19 and pre-existing Type 2 diabetes. Cell Metab 2020;32:537-47.e3. doi: 10.1016/j.cmet.2020.08.013, PMCID: PMC7439986, PMID: 32861268
Rodrigues TS, De Sá KS, Ishimoto AY, Becerra A, Oliveira S, Almeida L, et al. Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients. J Exp Med 2021;218:e20201707. doi: 10.1084/jem.20201707, PMID: 33231615; PMCID: PMC7684031
Lamkanfi M, Mueller JL, Vitari AC, Misaghi S, Fedorova A, Deshayes K,et al. Glyburide inhibits the cryopyrin/Nalp3 inflammasome. J Cell Biol 2009;187:61-70. doi: 10.1083/jcb.200903124, PMID: 19805629; PMCID: PMC2762099
Xiao L, Sakagami H, Miwa N. ACE2: The key molecule for understanding the pathophysiology of severe and critical conditions of COVID-19: Demon or Angel? Viruses 2020;12:491. doi: 10.3390/ v12050491, PMID: 32354022; PMCID: PMC7290508
Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003;426:450-4. doi: 10.1038/nature02145, PMID: 14647384; PMCID: PMC7095016
Mirabelli M, Chiefari E, Puccio L, Foti DP, Brunetti A. Potential benefits and harms of novel antidiabetic drugs during COVID-19 crisis. Int J Environ Res Public Health 2020;117:3664. doi: 10.3390/ ijerph17103664. PMID: 32456064; PMCID: PMC7277613
Sun B, Huang S, Zhou J. Perspectives of antidiabetic drugs in diabetes with coronavirus infections. Front Pharmacol 2021;11:592439. doi: 10.3389/fphar.2020.592439, PMID: 33584268; PMCID: PMC7878391
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