CONSUMPTION OF HYPERLIPIDEMIC DIET AND WATER INTAKE IN ALBINO RATS TREATED WITH ECLIPTA ALBA – ORIGINAL RESEARCH PAPER
DOI:
https://doi.org/10.22159/ajpcr.2023v16i9.47989Keywords:
Key words: Albino rats, Eclipta alba, Hyperlipidemic diet.Abstract
Objective: A high-fat (HF) diet described as higher calories generating from fat instead of carbohydrate or protein. HF usually diets a typical low-carbohydrate diet.
Methods: Thirty adult Albino rats of Wistar strain accurately weighing between 165 and 215 g utilized for the present the study. As per CPCSEA guidelines, the protocol was approved by the institutional animal ethical committee no. BMCH/IAEC/01 Anat/2015 dated June 4, 2015. Animals were maintained and fed with standard rat chow, HF diet, and clean drinking water ad libitum, commercially available and manufactured by the National Institute of Nutrition, Hyderabad.
Results: Rate of food consumption increased in rats fed with the HF diet for 8 weeks and decreased significantly in rats treated with Eclipta alba for 1, 2, and 3 weeks progressively compared to control group. Water intake increased in the rats fed with an HF diet (43±2.1) compared to rats fed with a normal diet, decreased significantly in the rats treated with E. alba (31±1.4) compared to the HF diet-fed animals.
Conclusion: The rate of food consumption increased in rats fed with the HF diet for 8 weeks and decreased significantly in rats treated with E. alba for 1, 2, and 3 weeks progressively compared to control group. Water intake increased in the rats fed with an HF diet compared to rats fed with a normal diet, decreased significantly in the rats treated with E. alba compared to the HF diet-fed animals
Downloads
References
Wang YC, Kong WZ, Jin QM, Chen J, Dong L. Effects of salvianolic acid B on liver mitochondria of rats with nonalcoholic steatohepatitis. World J Gastroenterol 2015;21:10104-12. doi: 10.3748/wjg.v21. i35.10104, PMID 26401075
Wang MY, Grayburn P, Chen S, Ravazzola M, Orci L, Unger RH. Adipogenic capacity and the susceptibility to Type 2 diabetes and metabolic syndrome. Proc Natl Acad Sci U S A 2008;105:6139-44. doi: 10.1073/pnas.0801981105, PMID 18413598
Soni KK, Soni SJ. Eclipta alba (L.) an ethnomedicinal herb plant, traditionally use in Ayurveda Hortic 2017;3:1-2.
Singh PA. Naturally occurring thiophene derivatives from Eclipta alba species. Bioact Mol 1988;7:179-86.
Mani DN, Bawankule DU, Saroj BK. Hyperlipidemic model: Studying lipid profile in small experimental animal 2012. Int J Pharm Pharm Sci 2012;4:337-40.
Marty M, Lui F. In: Stat Pearls. Treasure Island, FL: Stat Pearls Publishing; 2019.
Ramirez I. Does dietary hyperphagia contradict the lipostatic theory? Neurosci Biobehav Rev 1990;14:117-23. doi: 10.1016/s0149- 7634(05)80212-x, PMID 2190112
Chen WP, Ho BY, Lee CL, Lee CH, Pan TM. Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet. Int J Obes (Lond) 2008;32:1694-704. doi: 10.1038/ ijo.2008.156, PMID 1879489
Akagiri S, Naito Y, Ichikawa H, Mizushima K, Takagi T, Handa O, et al. A mouse model of metabolic syndrome; increase in visceral adipose tissue precedes the development of fatty liver and insulin resistance in high-fat diet-fed male KK/Ta mice. J Clin Biochem Nutr 2008;42:150-7. doi: 10.3164/jcbn.2008022, PMID 18385833
Buettner R, Schölmerich J, Bollheimer LC. High-fat diets: Modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring) 2007;15:798-808. doi: 10.1038/oby.2007.608, PMID 17426312
Matsuzawa-Nagata N, Takamura T, Ando H, Nakamura S, Kurita S, Misu H, et al. Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity. Metabolism 2008;57:1071-7. doi: 10.1016/j.metabol.2008.03.010, PMID 18640384
McIntyre N. Plasma lipids and lipoproteins in liver disease. Gut 1978;19:526-30. doi: 10.1136/gut.19.6.526, PMID 355066
Shiraev T, Chen H, Morris MJ. Differential effects of restricted versus unlimited high-fat feeding in rats on fat mass, plasma hormones and brain appetite regulators. J Neuroendocrinol 2009;21:602-9. doi: 10.1111/j.1365-2826.2009.01877.x, PMID 19490368
Published
How to Cite
Issue
Section
Copyright (c) 2023 Satheesh Naik K, B Ramanath, Bheemshetty S Patil, Lokanadham Sadhu
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.