ANALYTICAL METHODS FOR QUALITY CONTROL OF NANOFORMULATIONS-A REVIEW
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i10.48073Keywords:
Nanoparticles, Preparation, Characterization, ApplicationsAbstract
There has been a surge in enthusiasm for the creation of innovative medication modes of delivery that utilize nanoparticles in recent years. Nanoparticles provide substantial benefits compared to conventional drug delivery methods with strong stability, specificity, and drug consumption levels. The rate of release, the capacity to use alternative routes of delivery, and the capacity to give off drug compounds that are both hydrophilic and hydrophobic are all advantages. This study concentrates on nanoscale categorization, processing methods, characterization, utilization, and benefits.
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Allemann E, Gurny R, Doekler E. Drug-loaded nanoparticles preparation methods and drug targeting issues. Eur J Pharm Biopharm 1993;39:173-91.
Betancor L, Luckarift HR. Bioinspired enzyme encapsulation for biocatalysis. Trends Biotechnol 2008;26:566-72. doi: 10.1016/j. tibtech.2008.06.009, PMID 18757108 Dunne M, Bodmeier R, Huagang C. Indomethacin polymeric nanosuspensions prepared by micro-fluidization. J Control Release 1990;12:223-33. doi: 10.1016/0168-3659(90)90103-Z
Catarina PR, Ronald JN, Antonio JR. Nano capsulation 1. Method of preparation of drug-loaded polymeric nanoparticles: Nanotechnology. Biol Med 2006;2:8-21.
Cheng Y, Wang J, Rao T, He X, Xu T. Pharmaceutical applications of dendrimers: Promising nanocarriers for drug delivery. Front Biosci 2008;13:1447-71. doi: 10.2741/2774, PMID 17981642
Chorney M, Fishbein I, Danenberg HD, Golomb G. Lipophilic drug loaded nanospheres prepared by nanoprecipitation: Effect of formulation variables on size, drug recovery and release kinetics. J Controll Release 2002;83:389-400. doi: 10.1016/S0168-3659(02)00211-0
Couvreur P, Dubernet C, Puisieux F. Controlled drug delivery with nano particles: Current possibilities and future trends. Eur J Pharm Biopharm 1995;41:2-13.
De Assis DN, Mosqueira VC, Vilela JM, Andrade MS, Cardoso VN. Release profiles and morphological characterization by atomic force microscopy and photon correlation spectroscopy of 99m technetium-fluconazole nanocapsules. Int J Pharm 2008;349:152-60. doi: 10.1016/j. ijpharm.2007.08.002, PMID 17869460
El-Shabouri MH. Positively charged nano particles for improving the oral bioavailability of cyclosporine-A. Int J Pharm 2002;249:101-8. doi: 10.1016/s0378-5173(02)00461-1, PMID 12433438
Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S. Nano capsule formation by interfacial deposition following solvent displacement. Int J Pharm 1989;55:R1-4.
Fu HL, Cheng SX, Zhang XZ, Zhuo RX. Dendrimers/DNA complexes encapsulated in a water soluble polymer and supported on fast degrading star poly (D, L-lactide) for localized gene delivery. J Control Release 2007;124:181-8. doi: 10.1016/j.jconrel.2007.08.031, PMID 17900738
Goldberg M, Langer R, Jia X. Nanostructured materials for applications in drug delivery and tissue engineering. J Biomater Sci Polym Ed 2007;18:241-68. doi: 10.1163/156856207779996931, PMID 17471764
Gurny R, Peppas NA, Harrington DD, Banker GS. Development of biodegradable and injectable lattice for control release of potent drugs. Drug Dev Ind Pharm 1981;7:1-25. doi: 10.3109/03639048109055684
Hagens WI, Oomen AG, de Jong WH, Cassee FR, Sips AJ. What do we (need to) know about the kinetic properties of nanoparticles in the body Regul Toxicol Pharmacol 2007;49:217-29. doi: 10.1016/j. yrtph.2007.07.006, PMID 17868963
Hett A. Nanotechnology: Small matters, many unknown. Switzerland: Swiss Reinsurance Company; 2004. Hoet PH, Brüske-Hohlfeld I, Salata OV. Nanoparticles-known and unknown health risks. J Nanobiotechnology 2004;2:12.
Jaiswal J, Gupta SK, Kreuter J. Preparation of biodegradable cyclosporine nanoparticles by high-pressure emulsification-solvent evaporation process. J Control Release 2004;96:169-78. doi: 10.1016/j. jconrel.2004.01.017, PMID 15063039
Jani P, Halbert GW, Langridge J, Florence AT. Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency. J Pharm Pharmacol 1990;42:821-6. doi: 10.1111/j.2042- 7158.1990.tb07033.x, PMID 1983142
Jani P, Halbert GW, Langridge J, Florence AT. The uptake and translocation of latex nanospheres and microspheres after oral administration to rats. J Pharm Pharmacol 1989;41:809-12. doi: 10.1111/j.2042-7158.1989.tb06377.x, PMID 2576440
Jores K, Mehnert W, Drechsler M, Bunjes H, Johann C, Mäder K. Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy. J Control Release 2004;95:217-27.
Jung T, Kamm W, Breitenbach A, Kissel T, Kaiserling E, Xiao JK. Biodegradable nano particles for oral delivery of peptides: Is there a role for polymer to affect mucosal uptake. J Appl Pharm Sci 2011;1:228-34.
Kohler M, Fritzsche W. Nanotechnology: An Introduction to Nanostructuring. United States: Wiley; Koosha F, Muller RH, Davis SS, Davies MC. The surface chemical structure of poly (-hydroxybutyrate) microparticles produced by solvent evaporation process. J Control Release 1989;9:149-57.
Lademann J, Weigmann H, Rickmeyer C, Barthelmes H, Schaefer H, Mueller G, et al. Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol Appl Skin Physiol 1999;12:247-56. doi: 10.1159/000066249, PMID 10461093
Lambert G, Fattal E, Couvreur P. Nanoparticulate systems for the delivery of antisense oligonucleotides. Adv Drug Deliv Rev 2001;47:99- 112. doi: 10.1016/s0169-409x(00)00116-2, PMID 11251248
Larson DR, Zipfel WR, Williams RM, Clark SW, Bruchez MP, Wise FW, et al. Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science 2003;300:1434-6. doi: 10.1126/science.1083780, PMID 12775841
Bhavyasri K, Rambabu D, Prasad PS, Balaram VM. Separation of the two enantiomers of gatifloxacin by SFC on amylose based stationary phase. J Chem Pharm Res 2012;4:4915-20.
Forim MR, Costa ES, da Silva MF, Fernandes JB, Mondego JM, Boiça Junior AL. Development of a new method to prepare nano-/ microparticles loaded with extracts of Azadirachta indica, their characterization and use in controlling Plutella xylostella. J Agric Food Chem 2013;61:9131-9. doi: 10.1021/jf403187y, PMID 23991702
Krämer W, Schirmer U. Modern Crop Protection Compounds. Weinheim: Wiley; 2007. p. 1069-86.
Jansson R, Brown R, Cartwright B, Cox D, Dunbar D, Dybas R, et al. Proceedings of the 3rd International Workshop on Management of Diamondback Moth and Other Crucifer Pests. Kuala Lumpur, Malaysia: MARDI; 1997.
Cao Y, Huang L, Chen J, Liang J, Long S, Lu Y. Development of a controlled release formulation based on a starch matrix system. Int J Pharm 2005;298:108-16. doi: 10.1016/j.ijpharm.2005.04.005, PMID 15905051. Akelah A. Novel utilizations of conventional agrochemicals by controlled release formulations. Mater Sci Eng C 1996;4:83-98. doi: 10.1016/0928-4931(96)00133-6
Akelah A. In: Charcosset C, editor. Functionalized Polymeric Materials in Agriculture and the Food Industry. London: Springer; 2013. p. 133-92. Charcosset C, El-Harati A, Fessi H. Preparation of solid lipid nanoparticles using a membrane contactor. J Control Release 2005;108:112-20. doi: 10.1016/j.jconrel.2005.07.023
Choudhury SR, Pradhan S, Goswami A. Preparation and characterisation of acephate nano-encapsulated complex. Nanosci Methods 2012;1:9- 15. doi: 10.1080/17458080.2010.533443
Pradhan S, Roy I, Lodh G, Patra P, Choudhury SR, Samanta A, et al. Entomotoxicity and biosafety assessment of PEGylated acephate nanoparticles: A biologically safe alternative to neurotoxic pesticides. J Environ Sci Health B 2013;48:559-69. doi: 10.1080/03601234.2013.774891
Yang FL, Li XG, Zhu F, Lei CL. Structural characterization of nanoparticles loaded with garlic essential oil and their insecticidal activity against Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae). J Agric Food Chem 2009;57:10156-62. doi: 10.1021/jf9023118, PMID 19835357
Guo M, Zhang W, Ding G, Guo D, Zhu J, Wang B, et al. Preparation and characterization of enzyme-responsive emamectin benzoate microcapsules based on a copolymer matrix of silica-epichlorohydrin-carboxymethylcellulose. RSC Adv 2015;5:93170-9. doi: 10.1039/ C5RA17901G
Li ZZ, Chen JF, Liu F, Liu AQ, Wang Q, Sun HY, et al. Study of UV-shielding properties of novel porous hollow silica nanoparticle carriers for avermectin. Pest Manag Sci 2007;63:241-6. doi: 10.1002/ps.1301
Wang Y, Cui H, Sun C, Zhao X, Cui B. Construction and evaluation of controlled-release delivery system of abamectin using porous silica nanoparticles as carriers. Nanoscale Res Lett 2014;9:2490. doi: 10.1186/1556-276X-9-655, PMID 26088998. Popat A, Liu J, Hu Q, Kennedy M, Peters B, Lu GQ, et al. Adsorption and release of biocides with mesoporous silica nanoparticles. Nanoscale 2012;4:970- 5. doi: 10.1039/c2nr11691j, PMID 22200056
Meyer WL, Gurman P, Stelinski LL, Elman NM. Functional nano-dispensers (FNDs) for delivery of insecticides against phytopathogen vectors. Green Chem 2015;17:4173-7. doi: 10.1039/C5GC00717H
Musić S, Filipović-Vinceković N, Sekovanić L. Precipitation of amorphous SiO2 particles and their properties. Braz J Chem Eng 2011;28:89-94. doi: 10.1590/S0104-66322011000100011. Kim T, Chung P, Lin VS. Facile synthesis of monodisperse spherical MCM- 48 mesoporous silica nanoparticles with controlled particle size. Chem Mater 2010;22:5093-104. doi: 10.1021/cm1017344
Wang Y, Gao Z, Shen F, Li Y, Zhang S, Ren X, et al. Physicochemical characteristics and slow release performances of chlorpyrifos encapsulated by poly(butyl acrylate-co-styrene) with the cross-linker ethylene glycol dimethacrylate. J Agric Food Chem 2015;63:5196-204. doi: 10.1021/acs.jafc.5b01378, PMID 25946639
Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm 1983;15:25-35. doi: 10.1016/0378-5173(83)90064-9. Gu X, Kumar S, Kim E, Kim Y. A whole genome screening and RNA interference identify a juvenile hormone esterase-like gene of the diamondback moth, Plutella xylostella. J Insect Physiol 2015;80:81-7. doi: 10.1016/j. jinsphys.2015.02.001, PMID 25721055
Robertson JL, Smith KC, Savin N, Lavigne RJ. Effects of dose selection and sample size on the precision of lethal dose estimates in dose-mortality regression. J Econ Entomol 1984;77:833-7. Abbott WS. A method of computing the effectiveness of an insecticide. J Econ Entomol 1925;18:265-7.
Finney D. Probit Analysis. 3rd ed. London: Cambridge University Press; 1971.
Fernández-Pérez M, Villafranca-Sánchez M, Flores-Céspedes F, Daza-Fernández I. Ethylcellulose and lignin as bearer polymers in controlled release formulations of chloridazon. Carbohydr Polym 2011;83:1672-1679. Rao BS, Murthy KR. Studies on rifampicin release from ethylcellulose coated nonpareil beads. Int J Pharm 2002;231:97-106.
Wen LX, Li ZZ, Zou HK, Liu AQ, Chen JF. Controlled release of avermectin from porous hollow silica nanoparticles. Pest Manag Sci 2005;61:583-90. doi: 10.1002/ps.1032
Sayyed AH, Wright DJ. Genetics and evidence for an esterase-associated mechanism of resistance to indoxacarb in a field population of diamondback moth (Lepidoptera: Plutellidae). Pest Manag Sci 2006;62:1045-51. doi: 10.1002/ps.1270. Fernandes JB, da Silva MF, Forim MR, de Souza Bergo PL. Trdan S, editors. Insecticide Development of Safer and More Effective Technologies. Vol. 20. London: IntechOpen; 2013. p. 523-50.
Kushwaha AK, Gupta N, Chattopadhyaya MC. Adsorption behavior of lead onto a new class of functionalized silica gel. Arab J Chem 2017;10:S81-9. doi: 10.1016/j.arabjc.2012.06.010
Lokhande AB, Mishra S, Kulkarni RD, Naik JB. Influence of different viscosity grade ethylcellulose polymers on encapsulation and in vitro release study of drug loaded nanoparticles. J Pharm Res 2013;7:414- 20. Latheef MA, Dailey O, Franz E. Pesticide Formulations and Application Systems. Vol. 13. Philadelphia: American Society for Testing and Materials; 1993. p. 300-12.
Debnath N, Mitra S, Das S, Goswami A. Synthesis of surface functionalized silica nanoparticles and their use as entomotoxic nanocides. Powder Technol 2012;221:252-6. doi: 10.1016/j. powtec.2012.01.009
Vani C, Brindhaa U. Silica nanoparticles as nanocides against Corcyra cephalonica (S.), the stored grain pest. Int J Pharm Biol Sci 2013;4:B1108-18.
Choi E, Lu J, Tamanoi F, Zink JI. Drug release from three-dimensional cubic mesoporous silica nanoparticles controlled by nanoimpellers. Z Anorg Allg Chem 2014;640:588-94. doi: 10.1002/zaac.201300503
Izquierdo-Barba I, Sousa E, Doadrio JC, Doadrio AL, Pariente JP, Martínez A, et al. Influence of mesoporous structure type on the controlled delivery of drugs: Release of ibuprofen from MCM-48, SBA- 15 and functionalized SBA-15. J Sol Gel Sci Technol 2009;50:421-9. doi: 10.1007/s10971-009-1932-3
Trikalitis PN, Ding N, Malliakas C, Billinge SJ, Kanatzidis MG. Mesostructured selenides with cubic MCM-48 type symmetry: Large framework elasticity and uncommon resiliency to strong acids. J Am Chem Soc 2004;126:15326-7. doi: 10.1021/ja044954r, PMID 15563128. Schumacher K, Ravikovitch PI, Chesne AD, Neimark AV, Unger KK. Characterization of MCM-48 materials. Langmuir 2000;16:4648-54. doi: 10.1021/la991595i
O’Brien RW, Midmore BR, Lamb A, Hunter RJ. Electroacoustic studies of moderately concentrated colloidal suspensions. Faraday Discuss Chem Soc 1990;90:301-12. doi: 10.1039/dc9909000301
Hanaor D, Michelazzi M, Leonelli C, Sorrell CC. The effects of carboxylic acids on the aqueous dispersion and electrophoretic deposition of ZrO2. J Eur Ceram Soc 2012;32:235-44. doi: 10.1016/j. jeurceramsoc.2011.08.015
Bhattacharjee S. DLS and zeta potential-What they are and what they are not J Control Release 2016;235:337-51. Murtaza G. Ethylcellulose microparticles: A review. Acta Pol Pharm 2012;69:11-22.
Wang Y, Wang A, Wang C, Cui B, Sun C, Zhao X, et al. Synthesis and characterization of emamectin-benzoate slow-release microspheres with different surfactants. Sci Rep 2017;7:12761. doi: 10.1038/s41598- 017-12724-6, PMID 28986529
Torney F, Trewyn BG, Lin VS, Wang K. Mesoporous silica nanoparticles deliver DNA and chemicals into plants. Nat Nanotechnol 2007;2:295- 300. doi: 10.1038/nnano.2007.108, PMID 18654287
Rosenholm JM, Sahlgren C, Lindén M. Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles-- opportunities and challenges. Nanoscale 2010;2:1870-83. doi: 10.1039/ c0nr00156b, PMID 20730166
Saini P, Gopal M, Kumar R, Srivastava C. Development of pyridalyl nanocapsule suspension for efficient management of tomato fruit and shoot borer (Helicoverpa armigera). J Environ Sci Health B 2014;49:344-51. doi: 10.1080/03601234.2014.882168
Zhang DX, Li BX, Zhang XP, Zhang ZQ, Wang WC, Liu F. Phoxim microcapsules prepared with polyurea and urea-formaldehyde resins differ in photostability and insecticidal activity. J Agric Food Chem 2016;64:2841-6. doi: 10.1021/acs.jafc.6b00231, PMID 27010712
Hamedi SH. Determination of the scientific name of Zoufa: A traditional Persian medicinal plant. Trad Integr Med 2016;1:79-81.
Amin GR. Popular Medicinal Plants of Iran. Tehran: Iranian Ministry of Health Publications;. p. 40-4.
Joharchi MR, Amiri MS. Taxonomic evaluation of misidentification of crude herbal drugs marketed in Iran. Avicenna J Phytomed 2012;2:105- 12. PMID 25050238
Faraz M, Nickavar B, Tehrani HH. Essential oil analysis of nepetacrispa and N. menthoides from Iran. Iran J Pharm Sci 2009;5:43-6.
Kiritikar KR, Basu BD. Indian Medicinal Plants. Dehradun, India: International Book Distributers; 1990.
Avicenna. Kitabul Adviyatul Qalbia. Aligarh: National Printing Co.; 1956.
Bhatt J, Qudsia N, Aslam M, Ahmad S, Tanveer S. Pharmacognostical and phytochemical evaluation of nepeta bractaeta and HPTLC finger printing of its extracts. Int J Univers Pharm Life Sci 2012;2:147-8.
Said HM. Medicinal Herbs. Karachi: Hamdard Foundation Pakistan; 1996. p. 29-130.
Nadkarni AK. Indian Materia Medica. Bombay, India: Popularbook Depot; 1954. p. 673.
Ibn B. Al Jamiul Mufradatul Advia wal Aghzia (Urdu). New Delhi: Ministry of Health and Family Welfare; 1999. p. 185.
Ibn-e-Sina AA. In: Kantoori GH, Transl. Alqanoon Fit-Tibb. Lucknow: Matba Nawal Kishore; 1887. p. 288.
Hakeem MA. Bustanul Mufradat (Urdu Translation). Lucknow, India. Idara Taraqqi Urdu Publication; 1893. p. 188.
Lubhaya HR. Goswami Bayan-ul-Advia. New Delhi: Goswami Kutub Khana Gali Qasim; 1977. p. 303-4.
Ghani MN. Khazain-ul-Advia (Urdu Translation). Lahore, Pakistan: Sheikh Mohd Bashir and Sons; 1921. p. 768.
Vohora SB. Unani joshandah drugs for common cold, catarrh, cough and associated fevers. J Ethnopharmacol 1986;16:201-11.doi: 10.1016/0378-8741(86)90090-5, PMID: 3747564
Wang J, Li FS, Pang NN, Tian G, Jiang M, Zhang HP, et al. Inhibition of asthma in OVA sensitized mice model by a traditional Uygur herb Nepeta bracteata Benth. Evid Based Complement Alternat Med 2016;2016:5769897.
Bahmani M, Tajeddini P, Naghdi N, Kopaei MR. An ethno-medicinal study of medicinal plants used for thetreatment of diabetes. J Nephropathol 2016;5:44-50.
Latif A, Zeenat SN, Rauf A. Physiochemical standardization of market sample of Gul-e-Zoofa. Int J Drug Formul Res 2013;83:
Rahman K. Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging 2007;2:219-36.
Piluzza G, Bullitta S. Correlations between phenolic content and antioxidant properties in twenty-four plant species of traditional ethno veterinary use in the Mediterranean area. Pharm Biol 2011;49:240-7.
Fecka I, Raj D, Krauze-Baranowska M. Quantitative deter-mination of four water-soluble compounds in herbal drug from Lamiaceae using different chromatographic techniques. Chro-Matographia 2007;66:87-93.
Saeed N, Khan MR, Shabbir M. Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L. BMC Complement Altern Med 2012;12:221. doi: 10.1186/1472-6882- 12-221, PMID 23153304
Kumar S, Sandhir R, Ojha S. Evaluation of antioxidant activity and total phenol in different varieties of Lantana camara leaves. BMC Res Notes 2014;7:560. doi: 10.1186/1756-0500-7-560, PMID 25145266
Esmaeili AK, Taha RM, Mohajer S, Banisalam B. Antioxidant activity and total phenolic and flavonoid content of various solvent extracts from in vivo and in vitro Grown Trifolium pratense L. (Red Clover). Biomed Res Int 2015;2015:643285.
Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 1965;16:144-58.
Jain MK, Sharma SC. Modern Organic Chemistry. Jalandhar, India: Vishal Publishing Co; 2004. p. 1036-99.
Kumar D, Kumar K, Kumar S, Kumar T, Kumar A, Prakash O. Pharmacognostic evaluation of leaf and root bark of Holoptelea integrifolia Roxb. Asian Pac J Trop Biomed 2012;2:169-75. doi: 10.1016/S2221-1691(12)60036-7, PMID 23569892
Arya V, Gupta R, Gupta VK. Pharmacognostic and phyto-chemical investigations on Pyrus pashia Buch. Ham.ex D. Donstem bark. J Chem Pharm Res 2011;3:447-456.
Ansari SH. Essential of Pharmacognosy. 1st ed. New Delhi: Birla Publications Pvt, Ltd; 2007.
Kokoski CJ, Kokoski RJ, Slama FJ. Fluorescence of powdered vegetable drugs under ultraviolet radiation. J Am Pharm Assoc Am Pharm Assoc 1958;47:715-7.
Chase CR Jr., Pratt R. Fluorescence of powdered vegetable drugs with particular reference to development of a system of identification. J Am Pharm Assoc Am Pharm Assoc 1949;38:324-31.
Kähkönen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Kujala TS, et al. Antioxidant activity of plant extracts containing phenolic compounds. J Agric Food Chem 1999;47:3954-62. doi: 10.1021/ jf990146l.
Siddiqui N, Rauf A, Latif A, Mahmood Z. Spectrophotometric determination of the total phenolic content, spectral and fluorescence study of the herbal Unani drug Gul-e-Zoofa (Nepeta bracteata Benth). J Taibah Univ Med Sci 2017;12:360-3.
Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 2001;70:1-20. doi: 10.1016/s0168-3659(00)00339-4, PMID 11166403
Tabata Y, Ikada Y. Protein precoating of polylactide microspheres containing a lipophilic immunopotentiator for enhancement of macrophage phagocytosis and activation. Pharm Res 1989;6:296-301. doi: 10.1023/a:1015942306801, PMID 2748517
Takeuchi H, Yamamoto H, Kawashima Y. Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv Drug Deliv Rev 2001;47:39-54. doi: 10.1016/s0169-409x(00)00120-4, PMID 11251244
Tice TR, Gilley RM. Preparation of injectable controlledrelease microcapsules by solvent- evaporation process. J Control Release 1985;2:343-52. doi: 10.1016/0168-3659(85)90056-2
Tomalia DA. Birth of a new macromolecular architecture: Dendrimers as quantized building blocks for nanoscale synthetic organic chemistry. Aldrichimca Acta 2004;37:39-57.
Tomalin DA. Dendrimer as quantized building blocks for nanoscale synthetic organic chemistry. Aldrichimca Acta 2004;37:39-57.
Ubrich N, Bouillot P, Pellerin C, Hoffman M, Maincent P. Preparation and characterization of propranolol hydrochloride nanoparticles: A comparative study. J Control Release 2004;97:291-300. doi: 10.1016/j.jconrel.2004.03.023, PMID 15196756
Ueda M, Kreuter J. Optimization of the preparation of loperamide-loaded poly (L-lactide) nanoparticles by high pressure emulsification-solvent evaporation. J Microencapsul 1997;14:593-605. doi: 10.3109/02652049709006812, PMID 9292435
Vandervoort J, Ludwig A. Biocompatible stabilizers in the preparation of PLGA nanoparticles: A factorial design study. Int JPharm 2002;238:77-92. doi: 10.1016/s0378-5173(02)00058-3, PMID 11996812
Vargas A, Pegaz B, Debefve E, Konan-Kouakou Y, Lange N, Ballini JP, et al. Improved photodynamic activity of porphyrin loaded into nanoparticles: An in vivo evaluation using chick embryos. Int J Pharm 2004;286:131-45. doi: 10.1016/j.ijpharm.2004.07.029, PMID 15501010
Wiener EC, Brechbiel MW, Brothers H, Magin RL, Gansow OA, Tomalia DA, et al. Dendrimer-based metal chelates: A new class of magnetic resonance imaging contrast agents. Magn Reson Med 1994;31:1-8. doi: 10.1002/mrm.1910310102, PMID 8121264
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