ASSOCIATION OF SERUM LACTATE DEHYDROGENASE AND GAMMA-GLUTAMYL TRANSFERASE WITH PRE-ECLAMPSIA

NEETU KUMARI; NEHA SUTHAR; JASWANT KAUR; JYOTI DWIVEDI; VYAS R K

doi:10.22159/ajpcr.2023.v16i10.48107

Authors

NEETU KUMARI Department of Biochemistry, Dr. S.S. Tantia Medical College Hospital and Research Centre, Sri Ganganagar, Rajasthan, India.
NEHA SUTHAR Department of Biochemistry, Sal Institute of Medical Sciences, Ahmedabad, Gujarat, India.
JASWANT KAUR Department of Biochemistry, Dr. S.S. Tantia Medical College Hospital and Research Centre, Sri Ganganagar, Rajasthan, India.
JYOTI DWIVEDI Department of Physiology, Autonomous State Medical College, Firozabad, Uttar Pradesh, India.
VYAS R K Department of Biochemistry, Sardar Patel Medical College, Bikaner, Rajasthan, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i10.48107

Keywords:

Gamma-glutamyl transferase, Lactate dehydrogenase, Pre-eclampsia

Abstract

Objectives: Pre-eclampsia produces potentially lethal complications including placental abruption, hepatic failure, acute renal failure, and cardiovascular collapse. The present study was planned to find the association between serum lactate dehydrogenase (LDH) and gamma-glutamyl transferase (GGT) with pre-eclampsia and compare it with normal healthy control.

Methods: This hospital-based case–control study was conducted in the biochemistry department in collaboration with the Department of Gynaecology, Sardar Patel Medical College, Bikaner (Raj). 50 subjects to find whether there are any changes in the levels of serum LDH and GGT in pre-eclamptic patients (case group) compared to that of 50 normal pregnant women (control group).

Results: The present study has shown statistically significant (p<0.001) increases in serum LDH levels and GGT in pre-eclamptic patients compared to control subjects.

Conclusion: Serum LDH and GGT screening in early pregnancy may be helpful in predicting the occurrence of pre-eclampsia.

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