STUDY OF THYROID PROFILE, URIC ACID, CREATININE AND LIPID PROFILE IN PRE-ECLAMPSIA PATIENT

CHANCHLESH DEHARIYA; CHANDRASHEKHAR JAISWAL; RITESH UPADHYAY; DILEEP DANDOTIYA

doi:10.22159/ajpcr.2023.v16i6.48268

Authors

CHANCHLESH DEHARIYA Department of Pathology, CIMS, Chhindwara, Madhya Pradesh, India.
CHANDRASHEKHAR JAISWAL Department of Dermatology, CIMS, Chhindwara, Madhya Pradesh, India.
RITESH UPADHYAY Department of Community Medicine, CIMS, Chhindwara, Madhya Pradesh, India.
DILEEP DANDOTIYA Department of Community Medicine, CIMS, Chhindwara, Madhya Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i6.48268

Keywords:

Thyroid profile, Uric acid, Creatinine, Lipid profile, Pre-eclampsia

Abstract

Objectives: (1) To evaluate and compare the thyroid profile and lipid profile in preeclampsia in a normotensive pregnant female in the third trimester of pregnancy. (2) To estimate and compare serum uric acid and serum creatinine in preeclampsia in normotensive pregnant females.

Methods: In the present study, 154 patients, of which 79 preeclampsia (cases) and 75 (controls), were selected randomly and matched with their gestational age in patients who attended an ANC clinic at the Department of Obstetrics and Gynecology, NSCB Medical College, Jabalpur, from March 2016 to August 2017. All patients were evaluated for their lipid profile, thyroid profile, serum uric acid, and serum creatinine. The study includes patient’s specific detailed clinical history, physical examination findings, and a report of relevant investigations recorded from the patient who presented with pre-eclampsia and normotensive pregnant female attending the ANC Clinic of N.S.C.B. Medical College, Jabalpur.

Results: The most common age group for preeclampsia was 20–24 years. Preeclampsia was most common in the nullipara as compared to the multipara. Pre-eclampsia cases commonly occur in low-socioeconomic and rural areas. In this study, pre-eclamptic women showed higher serum concentrations of total cholesterol (221.60±22.55), low density lipoprotein (LDL) (134.44±16.96), Very LDL (48.48±6.88) and Triglyceride (243.50±32.33) when compared to normotensive women, which was statistically significant. In this study, a statistically significant decrease in HDLC (34.55±5.37) was observed in pre-eclamptic women. An increase in serum creatinine was observed in women with pre-eclampsia. The mean serum creatinine level was (1.21±0.47).

Conclusion: Our study concludes that nulliparous and low-socio-economic women had a higher risk of pre-eclampsia. Maternal age between 20 and 24 years are more prone to develop pre-eclampsia. Serum uric acid levels are significantly higher in pre-eclampsia patients and could be a useful indicator of maternal and fetal complications in hypertensive patients.

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References

Cunnigham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Wenstrom KD, et al. Hypertensive disorders in pregnancy. In: Cunnigham FG, Leveno KL, Bloom SL, editors. Williams Obstetrics. 22nd ed., ch. 34. New York: McGraw-Hill; 2005. p. 1237.

Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005;365:785-99. doi: 10.1016/S0140-6736(05)17987-2, PMID 15733721

Bellany L, Casas JP, Hingorani AD, Williams DJ. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: Systematic review and meta-analysis. BMJ 2007;335:974.

Solomon CG, Seely EW. Brief review: Hypertension in pregnancy: A manifestation of the insulin resistance syndrome? Hypertension 2001;37:232-9.

Gohil JT, Patel PK, Gupta P. Estimation of lipid profile in subjects of preeclampsia. J Obstet Gynaecol India 2011;61:399-403.

Arias F, Daftary SN, Bhide AG. Hypertensive Disorders of Pregnancy. Practical Guide to High Risk Pregnancy and Delivery. 3rd ed. p. 398.

Lampinen KH, Ronnback M, Groop PH, Kaaja RJ. A relationship between insulin sensitivity and vasodilation in women with a history of preeclamptic pregnancy. Hypertension 2008;52:394-401.

Kumar A, Ghosh BK, Murthy NS. Maternal thyroid hormonal status in preeclampsia. Indian J Med Sci 2005;59:57-63. doi: 10.4103/0019- 5359.13904, PMID 15738611

Malarewicz A, Gruszka O, Szymkiewicz J, Rogala J. The usefulness of routine laboratory tests in the evaluation of sudden threat of pregnant woman and fetus in pre-eclampsia. Ginekol Pol 2006;77:276-84. PMID 16875033

Rahman MH, Chowdhury MA, Alam MT. Serum thyroxine and triiodothyronine levels in normal pregnancy and pre-eclampsia. TAJ J Teach Assoc 2007;20:6-10.

Jayanta D, Mukhopadhyay A, Saha PK. Study of serum lipid profile in pregnancy induced hypertension. Indian J Clin Biochem 2006;21:165-8.

Kumar A, Ghosh BK, Murthy NS. Maternal thyroid hormonal status in preeclampsia. Indian J Med Sci 2005;59:57-63. doi: 10.4103/0019- 5359.13904, PMID 15738611

Stamilio DM, Sehdev HM, Morgan MA, Propert K, Macones GA. Can antenatal clinical and biochemical markers predict the development of severe preeclampsia? Am J Obstet Gynecol 2000;182:589-94.

Dekker G, Sibai B. Primary, secondary, and tertiary prevention of pre-eclampsia. Lancet 2001;357:209-15. doi: 10.1016/S0140- 6736(00)03599-6

Zilva JF, Pannal PR, Mayne PD. Clinical Chemistry in Dignosis and Treatment. 5th ed., vol. 18. London: Edward Arnold. p. 147.

Sheraz S, Boota M, Shahzad S. Eclampsia. Prof Med J 2006;13:27-31. doi: 10.29309/TPMJ/2006.13.01.5052

Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: Systematic review of controlled studies. BMJ 2005;330:565. doi: 10.1136/bmj.38380.674340.E0, PMID 15743856

Opitasari C, Andayasari L. Parity, education level and risk for (pre-) eclampsia in selected hospitals in Jakarta. Health Sci J Indones 2014;5:35-9.

Vani I, Gayathri A, Nagamani T, Sunieeta H. Lipid profile parameters in normal and pre-eclampsia complicating pregnancies-a prospective observational study. Ame J Sci Med Res 2015;1:61-6.

Somani SG, Somani VC, Babu PS, Vijayalaxmi A. To determine association of lipid profile, serum uric acid and body mass index as a marker for pre-eclampsia. Int J Curr Respir Res 2015;7.

Gohil JT, Patel PK, Gupta P. Estimation of lipid profile in subjects of preeclampsia. J Obstet Gynaecol India 2011;61:399-403.

Bainbridge SA, Roberts JM. Uric acid as a pathogenic factor in preeclampsia. Placenta 2008;29;Suppl A: S67-72. doi: 10.1016/j. placenta.2007.11.001, PMID 18093648

Sayyed A, Sontakke A. Study of lipid peroxidation and antioxidant status in preeclampsia. J Krishna Inst Med Sci Univ 2013;2:69-76.

Bargale A, Ganu JV, Trivedi DJ, Nagane NS, Mudaraddi R, Sagare A. Serum hs-CRP and uric acid as indicator of severity in preeclampsia. Int J Pharm Bio Sci 2011;2:340-5.

Shah DM. Role of the renin-angiotensin system in the pathogenesis of preeclampsia. Am J Physiol Renal Physiol 2005;288:F614-25.

Irani RA, Xia Y. Renin angiotensin signaling in normal pregnancy and preeclampsia. Semin Nephrol 2011;31:47-58. doi: 10.1016/j. semnephrol.2010.10.005, PMID 21266264

Redman CW, Beilin LJ, Bonnar J. Renal function in preeclampsia. J Clin Pathol 2000;29:91-4.

Kaveti SM, Kumar VS, Lakshmi AR, Audi A, Rajashree TK. Correlation of thyroid and lipid profile in preeclampsia patient. MRIMS J Health Sci 2014;2:84.

Pasupathi P, Mathiyalagan D, Rani P, Sankar KB, Kumar SP. Evaluation of serum lipids and thyroid hormone changes in non-pregnant, pregnant and PE women. Thyroid Sci 2009;4:CLS1-6.

Das S, Char D, Sarkar S, Saha TK, Biswas S. Evaluation of thyroid hormone changes in non-pregnant, normotensive pregnant and pregnancy with preeclampsia. IOSR J Dent Med Sci 2013;11:16-8.