ELECTROPHYSIOLOGICAL ASSESSMENT OF NERVE CONDUCTION IN DIABETES MELLITUS AND HYPERTENSION PATIENTS OF TERTIARY CARE HOSPITAL OF CENTRAL INDIA

Authors

  • Namrata Dubey Department of Physiology, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India
  • Shailesh Kumar Department of Physiology, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India
  • Ashima Farrukh Department of Physiology, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India
  • Prabhat Kumar Budholia Department of Physiology, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i10.48380

Keywords:

Diabetes mellitus, Nerve conduction velocity, Hypertension, Sensory nerves, Neurological investigation, Duration of diabetes

Abstract

Objectives: Nerve conduction studies (NCS) are electrophysiological tools used to assess the whole perseverance of the cranial and peripheral nervous systems; consequently, NCS seems to be diagnostically advantageous in the documentation and categorization of disorders concerning nerve roots, peripheral nerves, muscle, and neuromuscular junction, and are often complemented by needle electromyography. Hence, the current research was aimed to evaluate the electrophysiological nerve conduction among cases through diabetes and hypertension (HTN).

Methods: This prospective study was achieved with the cases attending the Department of Physiology, NSCB Medical College, after obtaining ethical clearance from the institution and the consent forms from all the patients, we have enrolled 165 patients on total, which grouped into three groups: Group Diabetes Mellitus [DM] = 55, Group HTN (Hypertension) = 55, and Group DM+ HTN (Diabetes with HTN) = 55. Patients willing to enroll for the study of either sex, of aged between 30 and 79 years with clinical and laboratory evidence of disorder, were included in the study.

Results: The mean duration for DM patients was 7.00±6.99 and for DM+HTN patients was 8.0±5.66 which was observed as statistically significant (p<0.0001). The observed fluctuations in the temperature as well as blood sugar showed statistically significant among the groups (p<0.0001). The variables, namely, median nerve, ulnar nerve, peroneal nerve, tibial nerve, and sural nerve sensory showed statistically significant among the groups (p<0.0001).

Conclusion: The hypertensive cases with diabetes have provocatively abnormal NCV parameters when compared with hypertensive cases without diabetes and cases with diabetes alone.

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References

Lago RM, Singh PP, Nesto RW. Diabetes and hypertension. Nat Clin Pract Endocrinol Metab 2007;3:667. doi: 10.1038/ncpendmet0638, PMID 17893686

Sadikot SM, Nigam A, Das S, Bajaj S, Zargar AH, Prasannakumar KM, et al. The burden of diabetes and impaired glucose tolerance in India using the WHO 1999 criteria: Prevalence of diabetes in India study (P.O.D.I.S.). Diabetes Res Clin Pract 2004;66:301-7. doi: 10.1016/j. diabres.2004.04.008, PMID 15609460

Bansal V, Kalita J, Misra UK. Diabetic neuropathy. Postgrad Med J 2006;82:95-100. doi: 10.1136/pgmj.2005.036137, PMID 16461471

Ashok S, Ramu M, Deepa R, Mohan V. Prevalence of neuropathy in Type 2 diabetic patients attending a diabetes centre in South India. J Assoc Physicians India 2002;50:546-50. PMID 12164406

Levitt NS, Stansberry KB, Wynchank S, Vinik AI. The natural progression of autonomic neuropathy and autonomic function tests in a cohort of people with IDDM. Diabetes Care 1996;19:751-4. doi: 10.2337/diacare.19.7.751, PMID 8799632

Rathmann W, Ziegler D, Jahnke M, Haastert B, Gries FA. Mortality in diabetic patients with cardiovascular autonomic neuropathy. Diabet Med 1993;10:820-4. doi: 10.1111/j.1464-5491.1993.tb00173.x, PMID 8281726

Linnenkamp U, Guariguata L, Beagley J, Whiting DR, Cho NH. The IDF Diabetes Atlas methodology for estimating global prevalence of hyperglycaemia in pregnancy. Diabetes Res Clin Pract 2014;103:186- 96. doi: 10.1016/j.diabres.2013.11.004, PMID 24300016

Dyck PJ. Evaluative procedures to detect, characterize, and assess the severity of diabetic neuropathy. Diabet Med 1991;8 Spec No: S48-51. doi: 10.1111/j.1464-5491.1991.tb02156.x, PMID 1825958

Aminoff MJ. Aminoff’s Electrodiagnosis in Clinical Neurology. Oxford: Elsevier.

Tesfaye S, Stevens LK, Stephenson JM, Fuller JH, Plater M, Ionescu- Tirgoviste C, et al. prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: The EURODIAB IDDM complications study. Diabetologia 1996;39:1377-84. doi: 10.1007/s001250050586, PMID 8933008

Tehrani KH. A study of nerve conduction velocity in diabetic patients and its relationship with tendon reflexes (T-reflex). Open Access Maced J Med Sci 2018;6:1072-6. doi: 10.3889/oamjms.2018.262, PMID 29983804

Harris M, Eastman R, Cowie C. Symptoms of sensory neuropathy in adults with NIDDM in the U.S. population. Diabetes Care 1993;16:1446-52. doi: 10.2337/diacare.16.11.1446, PMID 8299433

Mold JW, Vesely SK, Keyl BA, Schenk JB, Roberts M. The prevalence, predictors, and consequences of peripheral sensory neuropathy in older patients. J Am Board Fam Pract 2004;17:309-18. doi: 10.3122/ jabfm.17.5.309, PMID 15355943

Hoeldtke RD, Bryner KD, Horvath GG, Phares RW, Broy LF, Hobbs GR. Redistribution of sudomotor responses is an early sign of sympathetic dysfunction in Type 1 diabetes. Diabetes 2001;50:436-43. doi: 10.2337/diabetes.50.2.436, PMID 11272158

Jarmuzewska EA, Mangoni AA. Pulse pressure is independently associated with sensorimotor peripheral neuropathy in patients with Type 2 diabetes. J Intern Med 2005;258:38-44. doi: 10.1111/j.1365- 2796.2005.01500.x, PMID 15953131

Ponirakis G, Petropoulos IN, Alam U, Ferdousi M, Asghar O, Marshall A, et al. hypertension contributes to neuropathy in patients with Type 1 diabetes. Am J Hypertens 2019;32:796-803. doi: 10.1093/ ajh/hpz058, PMID 31013342

Ahmad I, Verma S, Noohu MM, Shareef MY, Hussain ME. Sensorimotor and gait training improves proprioception, nerve function, and muscular activation in patients with diabetic peripheral neuropathy: A randomized control trial. J Musculoskelet Neuronal Interact. 2020;20:234-48. PMID 32481239

Sheng JY, Blackford AL, Bardia A, Venkat R, Rosson G, Giles J, et al. Prospective evaluation of finger two-point discrimination and carpal tunnel syndrome among women with breast cancer receiving adjuvant aromatase inhibitor therapy. Breast Cancer Res Treat 2019;176:617-24. doi: 10.1007/s10549-019-05270-4, PMID 31079282

Kuala GK, Wolide AD, Dibaba FK, Fufa FG, Garedow AW, Tufa BE, et al. Patient awareness, prevalence, and risk factors of chronic kidney disease among diabetes mellitus and hypertensive patients at Jimma University Medical Center, Ethiopia. BioMed Res Int 2019;2019:2383508.

Talib SH, Punde G, Dase RK. Nerve conduction abnormalities in PreDiabetics and asymptomatic diabetics. J Assoc Physicians India 2018;66:29-32. PMID 30347948

Hussain G, Rizvi SA, Singhal S, Zubair M, Ahmad J. Serum levels of TGF-β1 in patients of diabetic peripheral neuropathy and its correlation with nerve conduction velocity in Type 2 diabetes mellitus. Diabetes Metab Syndr 2016;10(Suppl 1):S135-9. doi: 10.1016/j.dsx.2015.10.011, PMID 26559756

Andersen H, Stålberg E, Falck B. F wave latency, the most sensitive nerve conduction parameter in patients with diabetes mellitus. Muscle Nerve 1997;20:1296-302. doi: 10.1002/(sici)1097- 4598(199710)20:10<1296:aid-mus12>3.0.co;2-1, PMID 9324086

Ince H, Taşdemir HA, Aydin M, Ozyürek H, Tilki HE. Evaluation of nerve conduction studies in obese children with insulin resistance or impaired glucose tolerance. J Child Neurol 2015;30:989-99. doi: 10.1177/0883073814550188, PMID 25342307

Alsubiheen A, Petrofsky J, Daher N, Lohman E, Balbas E, Lee H. Tai Chi with mental imagery theory improves soleus H-reflex and nerve conduction velocity in patients with Type 2 diabetes. Complement Ther Med 2017;31:59-64. doi: 10.1016/j.ctim.2017.01.005, PMID 28434472

Singh K, Gupta K, Kaur S. High resolution ultrasonography of the tibial nerve in diabetic peripheral neuropathy. J Ultrason 2017;17:246-52. doi: 10.15557/JoU.2017.0036, PMID 29375899

Uluc K, Isak B, Borucu D, Temucin CM, Cetinkaya Y, Koytak PK, et al. Median plantar and dorsal sural nerve conduction studies increase the sensitivity in the detection of neuropathy in diabetic patients. Clin Neurophysiol 2008;119:880-5. doi: 10.1016/j.clinph.2008.01.001, PMID 18291716

Published

07-10-2023

How to Cite

Dubey, N., S. Kumar, A. Farrukh, and P. K. Budholia. “ELECTROPHYSIOLOGICAL ASSESSMENT OF NERVE CONDUCTION IN DIABETES MELLITUS AND HYPERTENSION PATIENTS OF TERTIARY CARE HOSPITAL OF CENTRAL INDIA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 16, no. 10, Oct. 2023, pp. 72-78, doi:10.22159/ajpcr.2023.v16i10.48380.

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