A CLINICOPATHOLOGICAL STUDY OF LESIONS OF BONE

Kaushik Bhuva; Anand  Vachhani; Paritosh Parmar; DIPMALA PATEL

doi:10.22159/ajpcr.2023.v16i12.48478

Authors

Kaushik Bhuva Department of Pathology, Shantabaa Medical College and General Hospital, Amreli, Gujarat, India.
Anand Vachhani Department of Pathology, Shantabaa Medical College and General Hospital, Amreli, Gujarat, India.
Paritosh Parmar Department of Anesthesiology, Shantabaa Medical College and General Hospital, Amreli, Gujarat, India.
DIPMALA PATEL Department of Pathologist, Lotus Pathology Laboratory, Ahmedabad, Gujarat, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i12.48478

Keywords:

Bone biopsy, Benign lesion, Malignant lesion, Tumor like lesions

Abstract

Objective: The objective is to study the clinico-pathological diagnosis of bone lesions.

Methods: The present study was a prospective and observational (non-interventional) type of study. A total of 100 patients from March 2012 to April 2013 were recruited. All excised bone specimens received in the Department of Pathology, SBKS MI and RC, Pipariya, constituted the study material. The specimens were subjected to a detailed histopathological examination. In each case, the pathological reaction pattern was studied carefully and documented.

Results: The total number of cases studied was one hundred, of which 63 were males and 37 were females in the age group of 3 years–65 years. The most common presenting symptoms were pain and swelling in all bone lesions. Out of 100 cases, non-neoplastic cases were 54% and neoplastic cases were 46%. Among 46% of neoplastic lesions, we found that 30% were benign and 16% were malignant. Among non-neoplastic lesions, 14% were tumor-like lesions, 13% were non-specific osteomyelitis, 12% were tuberculosis inflammation, and 15% were avascular necrosis. The most common benign lesion was a giant cell tumor (17%). The most common malignant lesion was osteosarcoma (6%). The most common tumor-like lesion was fibrous dysplasia (9%). The majority of bone tumors were located in the epiphysis of long bones.

Conclusion: Light microscopy or histopathological examination is the gold standard in the diagnosis of bone lesions and is invariably accurate when correlated with clinico-radiological features.

Downloads

Download data is not yet available.

References

Rosenberg AE. Bones, Joints, and soft tissue tumours. Kumar V, Abbas AK, Fausto N. Robbin and Cotran Pathologic Basis of Disease. 7th ed., Ch 26. India: Elsevier Inc; 2004. p. 1273-324.

Katchy KC, Ziad F, Alexander S, Gad H, Abdel Mota’al MA. Malignant bone tumours in Kuwait: A 10-year clinicopathological study. Int Orthop 2005;29:406-11. doi: 10.1007/s00264-005-0014-6, PMID 16200421

Birch JM, Alston RD, Kelsey AM, Quinn MJ, Babb P, McNally RJ. Classification and incidence of cancers in adolescents and young adults in England 1979-1997. Br J Cancer 2002;87:1267-74. doi: 10.1038/ sj.bjc.6600647, PMID 12439716

Negash BE, Admasie D, Wamisho BL, Tinsay MW. Bone tumours at Addis Ababa university, Ethiopia: Agreement between radiological and histopathological diagnoses, a-5-year analysis at Black-Lion teaching Hospital. Int J Med Med Sci 2009;1:119-25.

Obalum DC, Giwa SO, Banjo AF, Akinsulire AT. Primary bone tumours in a tertiary hospital in Nigeria: 25 year review. Niger J Clin Pract 2009;12:169-72. PMID 19764668

Popat VC, Sata VR. Role of histopathology in lytic lesions of bone. Internet J Orthop Surg 2011;19:1.

Peh SC, Cheah PL, Sengupta S. The pathology of tumour and ”tumour-lee” lesions of bone in the university hospital, Kuala Lumpur. Malays J Pathol 1988;10:45-50.

Rao VS, Pai MR, Rao RC, Adhikary MM. Incidence of primary bone tumours and tumour like lesions in and around Dakshina Kannada district of Karnataka. J Indian Med Assoc 1996;94:103-4, 124. PMID 8810207

Bahebeck J, Atangana R, Eyenga V. Bone tumours in Cameroon: Incidence, demography and histopathology. Int J Orthop 2003;27:315-7.