HISTOPATHOLOGICAL SPECTRUM OF PROSTATIC LESIONS AND THEIR CORRELATION WITH SERUM PROSTATE SPECIFIC ANTIGEN LEVELS

Pushpa; Namita Goyal; Ritul; Sukharam Bhamu

doi:10.22159/ajpcr.2024.v17i2.48487

Authors

Pushpa Department of Pathology, RNT Medical College, Udaipur, Rajasthan, India. https://orcid.org/0009-0000-6513-4913
Namita Goyal Department of Pathology, RNT Medical College, Udaipur, Rajasthan, India.
Ritul Department of Pathology, RNT Medical College, Udaipur, Rajasthan, India.
Sukharam Bhamu Department of Radiodiagnosis, GMCH, Udaipur, Rajasthan, India. https://orcid.org/0009-0000-6513-4913

DOI:

https://doi.org/10.22159/ajpcr.2024.v17i2.48487

Keywords:

Prostate, Benign prostatic hyperplasia, Prostate-specific antigen, Gleason grade

Abstract

Objectives: The present study is conducted to find out the histopathological spectrum of different prostatic biopsies and compare them with respective serum prostate-specific antigen (PSA) levels and grading, scoring of malignant lesions according to Gleason’s group grading system.

Methods: A total 165 prostatic biopsies from patients of >50 years of age groups were included in the study. This cross-sectional study was conducted in the Department of Pathology, R.N.T. Medical College, Udaipur, over a period of 1 year. The specimens were examined for various prostatic pathologies by doing histopathological examination and their serum PSA values were correlated.

Results: On histopathological examination, 76.9% of cases were of benign lesions, 14% of cases had prostatic malignancy, 6.6% of cases of inflammatory lesions, and 2.4% of cases of prostatic intraepithelial neoplasia. Majority of inflammatory lesions, prostate intraepithelial neoplasia, benign prostatic hyperplasia (BPH), and BPH with prostatitis had PSA level <4 ng/mL. In malignant cases, majority had PSA levels above 10 ng/mL. In prostatic adenocarcinoma, 56.32% of cases were found moderately differentiated grade (G2) followed by 30.43% of cases were of well-differentiated grade (G1) and 13.04% of cases of poorly differentiated grade (G3-G4).

Conclusion: The study showed a statistically positive correlation between histological diagnosis and serum PSA level.

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Author Biographies

Namita Goyal, Department of Pathology, RNT Medical College, Udaipur, Rajasthan, India.

Professor, Department of Pathology,

RNT MC, Udaipur

Ritul, Department of Pathology, RNT Medical College, Udaipur, Rajasthan, India.

Resident, Department of Pathology,

RNT MC, Udaipur

Sukharam Bhamu, Department of Radiodiagnosis, GMCH, Udaipur, Rajasthan, India.

Assistant Professor,

Department of Radiodiagnosis

GMCH Udaipur

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