SEROPREVALENCE OF TRANSFUSION-TRANSMITTED INFECTIONS AMONG VOLUNTARY BLOOD DONORS AT A TERTIARY CARE HOSPITAL
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i12.48560Keywords:
Hepatitis B, seroprevalence, Syphilis, Transfusion transmitted infectionsAbstract
Objectives: Blood transfusion is an effective treatment for saving millions of lives. However, transfusion-transmitted infections (TTIs) hamper blood safety. To prevent transmission of these diseases, screening for infections is an essential step for blood safety.
Aim: The aim of this study was to assess the seroprevalence of TTI among healthy voluntary blood donors.
Methods: This was a retrospective cross-sectional study at the Department of Immunohematology and Blood Transfusion, Tirunelveli Medical College and Hospital, Tirunelveli, for a period of 6 years from January 2017 to December 2022. Data of the blood donors screened were retrieved and analyzed with the aid of screening register and seropositive donor register over 2 months (December 2022 and January 2023).
Results: Among 53522 donors, 0.44% were seropositive for TTI (0.44%, n=233/53522) in which 99.57% (n=232/233) were male donors. Prevalence was more in 18–25 age group (39.91%, n=93/233). Hepatitis B virus (HBV) was the most prevalent microbe (n=144/53522) (0.27%). The prevalence of HBV showed a decreasing trend, while the prevalence of syphilis showed an increasing trend. The prevalence of human immunodeficiency virus, hepatitis C virus and malaria was unchanged.
Conclusion: Seroprevalence and changing trends of TTI among blood donors reveal the prevalence of infections in the general population which gives an idea of disease burden on society. Education about confidential unit exclusion and implementation can help reduce transmission risk and wastage.
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Bisetegen FS, Bekele FB, Ageru TA, Wada FW. Transfusion-transmissible infections among voluntary blood donors at Wolaita Sodo university teaching referral hospital, South Ethiopia. Can J Infect Dis Med Microbiol 2016;2016:8254343. doi: 10.1155/2016/8254343, PMID 27597875
Arun R, Subash S, Joshua DJ, Arumugam P. Seroprevalence of human Cytomegalovirus among voluntary blood donors in Chennai. Int J Med Health Sci 2012;1:21-6.
Makroo RN, Hegde V, Chowdhry M, Bhatia A, Rosamma NL. Seroprevalence of infectious markers and their trends in blood donors in a hospital based blood bank in North India. Indian J Med Res 2015;142:317-22. doi: 10.4103/0971-5916.166598, PMID 26458348
Sundaramoorthy R, Arunagiri R, Ganesan V, Perumal S, Tiruvanamalai R, Charles J. Seroprevalence of transfusion transmissible infections among blood donors by chemiluminescent assay in a tertiary care centre. J Infect Dev Ctries 2018;12:31-6. doi: 10.3855/jidc.9430, PMID 31628831
Pallavi P, Ganesh CK, Jayashree K, Manjunath GV. Seroprevalence and trends in transfusion transmitted infections among blood donors in a university hospital blood bank: A 5 year study. Indian J Hematol Blood Transfus 2011;27:1-6. doi: 10.1007/s12288-010-0047-x, PMID 22379287
Sujatha J, Raveendran M, Saranya D. Prevalence of transfusion transmissible infections among voluntary blood donors in a tertiary care hospital in Tamil Nadu. Paripex Indian J Res 2019;8:27-8.
Radhiga ST, Arumugam P, Kalpana S, Natarajan MV. Patterns of transfusion transmitted infection in past ten years among voluntary blood donors in Chennai-a cross sectional study. IOSR J Pharm Biol Sci 2012;2:1-4. doi: 10.9790/3008-0210104
Kumar R, Gupta S, Kaur A, Jindal A, Sharma H. Sero-prevalence and changing trends of transfusion transmitted infections among blood donors in a tertiary Care Hospital. Indian J Community Health 2015;27:25-9.
Dobariya GH, Raja KA, Unagar CA, Pandya AN, Patel JN, Jarag MA, et al. Prevalence and trends of transfusion transmitted infections among blood donors of blood bank attached to government hospital of South Gujarat, India. Int J Res Med Sci 2016;4:4123-7. doi: 10.18203/2320- 6012.ijrms20162946
Giri PA, Deshpande JD, Phalke DB, Karle LB. Seroprevalence of transfusion transmissible infections among voluntary blood donors at a tertiary care teaching hospital in rural area of India. J Family Med Prim Care 2012;1:48-51. doi: 10.4103/2249-4863.94452, PMID 24479001
Pachori S, Pachori P, Tiwari D, Purohit N. Seropositivity of transfusion transmitted infections in blood donors in blood bank, tertiary care centre of pediatric institute SPMCH hospital, Jaipur. Int J Med Sci Educ 2020;7:28-34.
Negi G, Gaur DS. Trends of transfusion transmissible diseases among blood donors at Uttarakhand, India. Indian J Community Med 2014;39:183-6. doi: 10.4103/0970-0218.137161, PMID 25136161
Siraj N, Achila OO, Issac J, Menghisteab E, Hailemariam M, Hagos S, et al. Seroprevalence of transfusion-transmissible infections among blood donors at national blood transfusion service, Eritrea: A seven-year retrospective study. BMC Infect Dis 2018;18:264. doi: 10.1186/ s12879-018-3174-x, PMID 29879912
Gaikwad AL, Poflee SV. Seroprevalence of transfusion transmitted infections among blood donors in a tertiary care teaching hospital in central India. Indian J Appl Res 2017;7:6-7.
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