VITAMIN C AS AN ADD ON SUPPLEMENTATION TO STANDARD ANTITUBERCULAR TREATMENT IMPROVES SPUTUM SMEAR CONVERSION IN NEWLY DIAGNOSED DRUG SENSITIVE PULMONARY TUBERCULOSIS PATIENTS

Mrugank Patel; Anita Sinha; Jeenal Mistry; Parul Vadgama; Khushbu Rathod; Bhargavi Patel

doi:10.22159/ajpcr.2024.v17i1.48683

Authors

Mrugank Patel Department of Pharmacology, Government Medical College, Surat, Gujarat, India. https://orcid.org/0009-0001-8070-9057
Anita Sinha Department of Pharmacology, Government Medical College, Surat, Gujarat, India.
Jeenal Mistry Department of Pharmacology, Government Medical College, Surat, Gujarat, India. https://orcid.org/0009-0007-3919-4614
Parul Vadgama Department of TB and Chest, Government Medical College, Surat, Gujarat, India.
Khushbu Rathod Department of Pharmacovigilance, APCER Life Sciences Limited, Ahmedabad, Gujarat, India.
Bhargavi Patel Department of Pharmacology, Dr. M. K. Shah Medical College and Research Centre and Smt. S. M. S. Multi-Specialty Hospital, Chandkheda, Ahmedabad, Gujarat, India. https://orcid.org/0009-0001-4710-4902

DOI:

https://doi.org/10.22159/ajpcr.2024.v17i1.48683

Keywords:

Tuberculosis, Vitamin C, Sputum Smear Conversion, Anti-tubercular Treatment

Abstract

Objective: This study was aimed to evaluate the effect of oral supplementation of Vitamin C along with standard anti-tubercular (anti-TB) drugs on the sputum smear conversion in newly diagnosed pulmonary tuberculosis (TB) patients.

Methods: This was a prospective, observational study in which 49 newly diagnosed pulmonary TB patients were given oral vitamin C supplementation along with standard anti-TB treatment during the intensive phase (2 months) of the treatment. An examination of the sputum smear at the end of the intensive phase of anti-tubercular treatment was done. At the end of the intensive phase, a comparison was done between the results of the sputum smear examination of the study population and the TB patients of the general population from the same locality who were receiving only standard anti-TB treatment and not add on Vitamin C supplementation.

Results: The comparison between the results of the study population (sputum conversion–100%) with those of the general population (sputum conversion–92.47%) shows a significant difference between both populations with p<0.05 (p=0.041).

Conclusion: This study showed that Vitamin C supplementation as an add-on therapy to the existing standard anti-TB treatment improves sputum smear conversion and decreases disease activity to a greater extent than routine standard anti-TB treatment alone.

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