ADVERSE DRUG REACTIONS AMONG PATIENTS IN DEPARTMENT OF MEDICINE IN A TERTIARY CARE TEACHING HOSPITAL, KOLLAM

Authors

  • Beena JS Department of Pharmacology, Government Medical College, Trivandrum, Kerala, India.
  • Rakesh Praveen Raj MR Department of General Surgery, Azeezia Institute of Medical Sciences and Research, Meeyyannoor, Kerala, India. https://orcid.org/0009-0009-2173-4656
  • Reeja R Department of Pharmacology, Government Medical College, Kollam, Kerala, India.
  • Bindulatha Nair R Department of Pharmacology, Azeezia Institute of Medical Sciences and Research, Meeyyannoor, Kerala, India.
  • Reshma L Pavithran Department of General Medicine, Government Medical College, Kollam, Kerala, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i12.48901

Keywords:

Adverse drug reaction, Medicine, Pharmacovigilance, ADR reporting, Patient safety

Abstract

Objectives: Pharmacovigilance practices are still in the infancy in India, more so in South India. adverse drug reactions (ADRs) are often underreported and the risks are higher in adults and elderly due to the association of comorbidities, self-medication, combination of indigenous systems of medicines and modern medicine, and so on. The present study was done with the objective to analyze the ADRs among patients in the general medicine department, Government Medical College, Kollam. The primary objective is to determine the prevalence and nature of ADRs and secondary objective to assess the causality, severity, and preventability of the ADRs.

Methods: In this cross-sectional study done in the Department of Medicine, Government Medical College, Kollam, 1000 patients of either sex were analyzed using CDSCO ADR reporting forms and the approved scales for causality, severity, and preventability.

Results: Among 1000 patients studied, the prevalence of ADRs was 7.6%. The most common system involved were dermatological (41%) followed by cardiovascular (18%) and gastrointestinal and neurology (16% each). Majority of the ADRs came under probable (48.7%) with a Naranjo score of 5 (40.8%), of moderate severity (65.8%) and not preventable (71.1%).

Conclusion: ADRs pose a major problem needing hospital stay or prolonging the duration of stay. Developing an ongoing ADR reporting system with continuous motivation and creating awareness among the healthcare professionals for reporting suspected ADRs will help to continue reporting and improving the patient safety. Improved communication of health-care professionals with the pharmacovigilance centers should be promoted for better patient healthcare.

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Author Biographies

Rakesh Praveen Raj MR, Department of General Surgery, Azeezia Institute of Medical Sciences and Research, Meeyyannoor, Kerala, India.

Dr Rakesh Praveen Raj MR

MS General Surgery

Professor, Dept of General Surgery,

Azeezia Institute of Medical Sciences & Research, Meeyyannoor.

Email: drrakeshpraveenraj@gmail.com

Reeja R, Department of Pharmacology, Government Medical College, Kollam, Kerala, India.

Dr Reeja R.,

MD Pharmacology

Associate Professor, Dept. of Pharmacology,

Govt. Medical College, Kollam, Kerala

Email: drreejapraveen@gmail.com

Bindulatha Nair R, Department of Pharmacology, Azeezia Institute of Medical Sciences and Research, Meeyyannoor, Kerala, India.

Dr Bindhulatha Nair R

MD Pharmacology

Prof & HOD, Dept of Pharmacology

Govt Medical college, Kollam

Email: bln_28@yahoo.com

Reshma L Pavithran, Department of General Medicine, Government Medical College, Kollam, Kerala, India.

Dr Reshma L Pavithran

MBBS, House Surgeon.

Govt Medical college, Kollam

Email: molootty98@gmail.com

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Published

07-12-2023

How to Cite

JS, B., R. P. Raj MR, R. R, B. Nair R, and R. L Pavithran. “ADVERSE DRUG REACTIONS AMONG PATIENTS IN DEPARTMENT OF MEDICINE IN A TERTIARY CARE TEACHING HOSPITAL, KOLLAM”. Asian Journal of Pharmaceutical and Clinical Research, vol. 16, no. 12, Dec. 2023, pp. 65-68, doi:10.22159/ajpcr.2023.v16i12.48901.

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