IMPACT OF PHARMACOLOGICAL TREATMENT ON CARDIOVASCULAR AUTONOMIC FUNCTION TESTS IN PATIENTS OF OCD AND ITS CLINICAL RELEVANCE: A FOLLOW-UP STUDY

Sharanjeet kaur; Rajeev Sharma; Prinka arora; Arvind Sharma

doi:10.22159/ajpcr.2024.v17i2.48944

Authors

Sharanjeet kaur Department of Psychiatry, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.
Rajeev Sharma Department of Physiology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India. https://orcid.org/0009-0001-5550-0403
Prinka arora Department of Psychiatry, GMCH, Chandigarh, Punjab, India. https://orcid.org/0000-0002-1577-2789
Arvind Sharma Department of Psychiatry, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India. https://orcid.org/0000-0001-5780-2184

DOI:

https://doi.org/10.22159/ajpcr.2024.v17i2.48944

Keywords:

Autonomic function test, Heart rate variability, Obsessive-compulsive disorder

Abstract

Objectives: Obsessive-compulsive disorder (OCD) is associated with increased mortality due to coronary artery disease. Autonomic dysfunction has been associated with an increased risk of developing cardiovascular illness. Thus, this study examined that autonomic dysfunction is inherent in the disease process and it improves with early initiation of treatment.

Methods: A total of 50 drug-naive patients meeting the ICD-10 criteria for OCD were subjected to autonomic function tests at baseline and then follow-up assessments were done at the 3rd and 6th month of treatment. The follow-up parameters were compared statistically with the baseline parameters.

Results: Difference of time domain parameters of heart rate variability at baseline and second follow-up were statistically significant (p<0.05). Difference of frequency domain parameters of HRV at baseline and second follow-up were also statistically significant (p=0.000).

Conclusion: OCD is characterized by inherent autonomic dysfunction. Thus, physicians should carefully monitor metabolic and cardiovascular health in patients with OCD early in the course of the disorder and early initiation of treatment can further prevent these cardiovascular events.

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Author Biographies

Sharanjeet kaur, Department of Psychiatry, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

She was PG Resident in Department of Psychiatry, Guru Gobind Singh Medical college and hospital, Faridkot. Currently working as Medical officer in BATHINDA

Rajeev Sharma, Department of Physiology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

He is Professor & Head, Department of Physiology, Guru Gobind Singh Medical college and hospital, Faridkot.

Arvind Sharma, Department of Psychiatry, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

He is Ex Professor & Head, Department of Psychiatry, Guru Gobind Singh Medical college and hospital, Faridkot. Currently working as Consultant Psychiatrist at his own clinic.

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