COMPARATIVE OUTCOME OF NEONATES BORN TO SARS-COV2 (RTPCR TEST) POSITIVE MOTHERS IN 1ST, 2ND, AND 3RD WAVE OF COVID PANDEMIC AT A TERTIARY CARE HOSPITAL IN NORTH INDIA
DOI:
https://doi.org/10.22159/ajpcr.2024.v17i3.49007Keywords:
Perinatal, Pregnant mothers, Premature, Positive test, SARS‑CoV‑2, NeonatesAbstract
Objectives: To access the incidence of perinatal transmission of SARS‑CoV‑2 virus from pregnant mothers having RTPCR test positive for SARS‑CoV‑2 virus to their newborn babies, to evaluate the morbidity and mortality in these neonates, and to compare the outcomes of these neonates during the first, second, and third waves of the COVID pandemic (March 2020–July 2022) admitted at a tertiary care health facility in North India (Punjab).
Methods: Data were retrospectively gathered from hospital records for all neonates born to pregnant women who had tested positive for the virus using the RTPCR method from March 2020 to July 2022, when the SARS‑CoV‑2 pandemic was in full swing. In order to assess the relationship between various maternal and perinatal risk factors, a thorough history of the neonate and the pregnant mother was recorded.
Results: During the COVID-19 outbreak, 168 neonates in total were born to mothers who tested positive for the SARS‑CoV‑2 virus. The majority of these neonates were healthy, although the premature birth rate was higher. Our study’s results show a statistically significant relationship between pregnancy-related issues and newborn problems like premature births, low neonatal weight, newborns exhibiting one or more disease symptoms, and poorer neonatal outcomes.
Conclusions: According to our research, there was very little perinatal transmission of the SARS‑CoV‑2 virus from the pregnant mothers to the newborns. Although there were more premature babies, most of them managed to survive.
Downloads
References
World Health Organization. WHO Coronavirus (COVID-19) Dashboard. p. 2022. Available from: https://www.covid19.who.int
Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;382:1708-20. doi: 10.1056/NEJMoa2002032, PMID 32109013
Chmielewska B, Barratt I, Townsend R, Kalafat E, Meulen J. Impact of the COVID-19 pandemic on maternal and perinatal outcomes: A systematic review and meta-analysis. Lancet Glob Health 2021;9:e759-72.
Royal College of Obstetricians and Gynaecologists. Coronavirus (COVID-19) Infection in Pregnancy. England: Royal College of Obstetricians and Gynaecologists; 2020.
Raschetti R, Vivanti AJ, Vauloup-Fellous C, Loi B, Benachi A, De Luca D. Synthesis and systematic review of reported neonatal SARS-CoV-2 infections. Nat Commun 2020;11:5164. doi: 10.1038/ s41467-020-18982-9, PMID 33060565
Blumberg DA, Underwood MA, Hedriana HL, Lakshminrusimha S. Vertical transmission of SARS-CoV-2: What is the optimal definition? Am J Perinatol 2020;37:769-72. doi: 10.1055/s-0040-1712457, PMID 32503058
Shah PS, Diambomba Y, Acharya G, Morris SK, Bitnun A. Classification system and case definition for SARS-cov-2 infection in pregnant women, fetuses, and neonates. Acta Obstet Gynecol Scand 2020;99:565-8. doi: 10.1111/aogs.13870, PMID 32277845
More K, Chawla D, Murki S, Tandur B, Deorari AK, Kumar P, et al. Outcomes neonates born to mothers coronavirus disease 2019 (COVID-19) - national neonatology forum (NNF) India COVID-19 registry. Indian Pediatr 2021;58:525-31.
Falsaperla R, Giacchi V, Lombardo G, Mauceri L, Lena G, Saporito MA, et al. Neonates born to COVID-19 mother and risk in management within 4 weeks of life: A single-center experience, systematic review, and meta-analysis. Am J Perinatol 2021;38:1010-22. doi: 10.1055/s- 0041-1729557. PMID 34082444
Dhir SK, Kumar J, Meena J, Kumar P. Clinical features and outcome of SARS-CoV-2 infection in neonates: A systematic review. J Trop Pediatr 2021;67:fmaa059. doi: 10.1093/tropej/fmaa059, PMID 32856065
Ohuma E, Moller AB, Bradley E, Chakwera S, Hussain-Alkhateeb L, Lewin A, et al. National, regional, and worldwide estimates of preterm birth in 2020, with trends from 2010: A systematic analysis. Lancet 2023;402:1261-71.
Gale C, Quigley MA, Placzek A, Knight M, Ladhani S, Draper ES, et al. Characteristics and outcomes of neonatal SARS-cov-2 infection in the UK: A prospective national cohort study using active surveillance. Lancet Child Adolesc Health 2021;5:113-21. doi: 10.1016/S2352- 4642(20)30342-4, PMID 33181124
Sánchez-Luna M, Fernández Colomer B, Alba Romero C, Allen AA, Souto AB, Longueira FC, et al. Neonates born to mothers with COVID-19: Data from the Spanish society of neonatology registry. Pediatrics 2021;147:e2020015065.
Kirtsman M, Diambomba Y, Poutanen SM, Malinowski AK, Vlachodimitropoulou E, Parks WT, et al. Probable congenital SARSCoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection. CMAJ 2020;192:E647-50. doi: 10.1503/ cmaj.200821, PMID 32409520
Schwartz DA, Morotti D, Beigi B, Moshfegh F, Zafaranloo N, Patanè L. Confirming vertical fetal infection with COVID-19: Neonatal and pathology criteria for early onset and transplacental transmission of SARSCoV-2 from infected pregnant mothers [published online ahead of print Jul 23, 2020]. Arch Pathol Lab Med 2020;144:1451-6. doi: 10.5858/arpa.2020-0442-SA, PMID 32886737
Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: A retrospective, single-centre descriptive study. Lancet Infect Dis 2020;20:559-64. doi: 10.1016/S1473-3099(20)30176-6, PMID 32220284–56430
World Health Organization. Breastfeeding Advice during the COVID-19 Outbreak. Available from: http://www.emro.who.int/ nutrition/nutrition-infocus/breastfeeding-advice-during-covid-19- outbreak.html [Last accessed on 2020 Jun 15].
Leibowitz J, Krief W, Barone S, Williamson KA, Goenka PK, Rai S, et al. Comparison of clinical and epidemiologic characteristics of young febrile infants with and without severe acute respiratory syndrome coronavirus-2 infection. J Pediatr 2021;229:41-7.e1. Reports on outcomes in newborns infected with SARS-CoV-2 in a medical center in New York. Unique in that it Compares Febrile Infants Seen in the Medical Center Across the years 2018, 2019, and 2020. doi: 10.1016/j.jpeds.2020.10.002, PMID 33045235, Allowing for Investigation of Differences in Newborn Presentation of SARS-CoV-2 Versus other Viruses.
Norman M, Navér L, Söderling J, Ahlberg M, Hervius Askling H, Aronsson B, et al. Association of maternal SARS-CoV-2 infection in pregnancy with neonatal outcomes. JAMA 2021;325:2076-86. Reports on 92% of all live births in Sweden from March 2020 through. doi: 10.1001/jama.2021.5775, PMID 33914014. SARS-CoV-2-infected and uninfected pregnant women were matched based on maternal characteristics known to affect neonatal outcomes, allowing for meaningful comparisons in outcomes between SARS-CoV-2 exposed and unexposed newborns.
Mithal LB, Machut KZ, Muller WJ, Kociolek LK. SARS-CoV-2 infection in infants less than 90 days old. J Pediatr 2020;224:150-2. doi: 10.1016/j.jpeds.2020.06.047, PMID 32565095
Mullins E, Hudak ML, Banerjee J, Getzlaff T, Townson J, Barnette K, et al. Pregnancy and neonatal outcomes of COVID-19: Coreporting of common outcomes from PAN-COVID and AAPSONPM registries. Ultrasound Obstet Gynecol 2021;57:573-81. doi: 10.1002/uog.23619, PMID 33620113
Published
How to Cite
Issue
Section
Copyright (c) 2023 Surinder kaur surinder, Dr Tanya Thakkar, Dr Baljinder kaur
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.