RED CELL DISTRIBUTION WIDTH – AN IGNORED BUT EMERGING INDICATOR TO PREDICT ADVERSE EVENTS IN HYPERTENSIVE PATIENTS
DOI:
https://doi.org/10.22159/ajpcr.2024.v17i2.49059Keywords:
Erythrocyte, Red blood cell indices, Red blood cell distribution width value, HypertensionAbstract
Objectives: Hypertension (HT) is related to the development of ischemic heart disease, heart failure, stroke, and chronic kidney disease. It is one of the primary causes of long-term morbidity and mortality. Past studies showed that red blood cell (RBC) morphology plays a significant role in inflammatory conditions of HT. Hence, this study was conducted to find association of erythrocyte parameters like RBC distribution width (RDW) with arterial blood pressure in hypertensives.
Methods: The study was conducted in two groups: study and control. Fifty hypertensives and 50 normotensives between 40 and 60 years, matching inclusion and exclusion criteria were involved, and blood samples were taken and analyzed.
Results: Our study has found significantly low values of mean corpuscular volume and mean corpuscular hemoglobin in the study group. However, the study group shows significantly high RDW values as compared to control group.
Conclusion: High RDW values in hypertensives are a strong indicator of RBC abnormality, and it is associated with various vascular complications along with end-organ damage.
Downloads
References
Karabulut A, Karadag A. Clinical implication of hematological indices in the essential hypertension. World J Hypertens 2015;5:93-7. doi: 10.5494/wjh.v5.i2.93
Ghosh S, Kumar M. Prevalence and associated risk factors of hypertension among persons aged 15-49 in India: A cross-sectional study. BMJ Open 2019;9:e029714. doi: 10.1136/bmjopen-2019-029714, PMID 31848161
Hypertension. Available from: https://www.who.int/india/health-topics/ hypertension
Ramakrishnan S, Zachariah G, Gupta K, Shivkumar Rao J, Mohanan PP, Venugopal K, et al. Prevalence of hypertension among Indian adults: Results from the great India blood pressure survey. Indian Heart J 2019;71:309-13. doi: 10.1016/j.ihj.2019.09.012, PMID 31779858
Jacob PR, Sally MK, John BE, Frank BM, Sampson A, Francesco PC. Blood pressure and haematological indices in twelve communities in Ashanti, Ghana. Int J Hypertens 2018;2018:5952021.
Kwon H, Park B. Borderline-high mean corpuscular volume levels are associated with arterial stiffness among the apparently healthy Korean individuals. Korean J Fam Med 2020;41:387-91. doi: 10.4082/ kjfm.19.0061, PMID 31955550
Tsuda K. Red blood cell abnormalities and hypertension. Hypertens Res 2020;43:72-3. doi: 10.1038/s41440-019-0353-0, PMID 31666713
Li N, Zhou H, Tang Q. Red blood cell distribution width: A novel predictive indicator for cardiovascular and cerebrovascular diseases. Dis Markers 2017;2017:7089493. doi: 10.1155/2017/7089493, PMID 29038615
Danese E, Lippi G, Montagnana M. Red blood cell distribution width and cardiovascular diseases. J Thorac Dis 2015;7:E402-11. doi: 10.3978/j.issn.2072-1439.2015.10.04, PMID 26623117
Atsma F, Veldhuizen I, De Kort W, Van Kraaij M, Pasker-de Jong P, Deinum J. Hemoglobin level is positively associated with blood pressure in a large cohort of healthy individuals. Hypertension 2012;60:936-41. doi: 10.1161/HYPERTENSIONAHA.112.193565, PMID 22949533
Lee SG, Rim JH, Kim JH. Association on of haemoglobin levels with blood pressure and hypertension in a large population-based study: The Korea national health and nutrition examination surveys 2008-2011. Clin Chim Acta 2015;438:12-8.
Sunbul M, Gerin F, Durmus E, Kivrak T, Sari I, Tigen K, et al. Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension. Clin Exp Hypertens 2013;36:217-21.
McDonough JR, Hames CG, Garrison GE, Stulb SC, Lichtman MA, Hefelfinger DC. The relationship of hematocrit to cardiovascular states of health in the Negro and white population of Evans County. Georgia. J Chron Dis 1965;18:243-57. doi: 10.1016/0021-9681(65)90151-7, PMID 14278160
Bao W, Dalferes ER, Srinivasan SR, Webber LS, Berenson GS. Normative distribution of complete blood count from early childhood through adolescence: The Bogalusa heart study. Prev Med 1993;22:825- 37. doi: 10.1006/pmed.1993.1075, PMID 8115341
Devereux RB, Case DB, Alderman MH, Pickering TG, Chien S, Laragh JH. Possible role of increased blood viscosity in the hemodynamics of systemic hypertension. Am J Cardiol 2000;85:1265- 8. doi: 10.1016/s0002-9149(00)00744-x, PMID 10802017
Cirillo M, Laurenzi M, Trevisan M, Stamler J. Hematocrit, blood pressure, and hypertension. The Gubbio population study. Hypertension 1992;20:319-26. doi: 10.1161/01.hyp.20.3.319, PMID 1516951
Ali I, Yasmeen N. A comparative study of hematological parameters in normal and hypertensive individuals. Int J Physiol 2017;5:35-40. doi: 10.5958/2320-608X.2017.00008.7
Seo SG, Lee MY, Park SH, Han JM, Lee KB, Kim H, et al. The association between red cell distribution width and incident hypertension in Korean adults. Hypertens Res 2020;43:55-61. doi: 10.1038/s41440- 019-0334-3, PMID 31551565
Published
How to Cite
Issue
Section
Copyright (c) 2023 Dr.Hardikkumar Mistry, Dr.Dharitri Parmar
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
