VITAMIN D STATUS AND ITS EFFECT ON FUNCTIONAL OUTCOME IN PATIENTS WITH HIP FRACTURE: AN OBSERVATIONAL STUDY

Authors

  • KARAN HINGANKAR Department of Orthopedics, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli, Maharashtra, India.
  • AVINASH KEDARI Department of Orthopedics, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli, Maharashtra, India.
  • RAJ PRAMOD GANDHI Department of Orthopedics, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli, Maharashtra, India.
  • RAHIL JIWANI Department of Orthopedics, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli, Maharashtra, India

DOI:

https://doi.org/10.22159/ajpcr.2023v16i10.49260

Keywords:

Hip fracture, Modified Harris Hip Score, Vitamin D, Functional Outcome

Abstract

Objectives: The study aimed to study the Vitamin D status of adult patients presenting with hip fractures and analyze potential impact of Vitamin D status on outcome of these patients.

Methods: This was an observational study of Vitamin D status of patients presenting with hip fractures. It was conducted in the department of orthopedics of a tertiary care medical college. One hundred and twenty adult patients presenting with hip fractures were included in this study on the foundation of a predefined inclusion and exclusion criteria. Demographic details of all the patients such as age, gender, and socioeconomic status were noted. Vitamin D status of patients was determined and correlated with functional outcome at the time of final follow-up visit at 6 months.

Results: Among the 120 studied with hip fractures, 64 cases (53.33%) involved females, while 56 cases (46.67%) involved males having a M: F ratio of 1:1.14. The mean age of male and female patients was found to be 45.85±10.12 and 46.74±9.86 years. Overall, 65 (54.17%) patients were Vitamin D sufficient and remaining 55 (45.83%) were either inefficient (26.67%) or deficient (19.17%). Seventy-three (60.83%) patients had excellent to good outcome whereas 31 (25.83%) patients had fair outcome. Out of remaining 16 patients, 11 (9.17%) patients had poor outcome and 5 (4.17%) patients had very poor outcome. The patients with sufficient Vitamin D status were found to have a better outcome as compared to those patients with inefficient or deficient Vitamin D status and the difference was found to be statistically significant (p=0.01).

Conclusion: It is significant to treat Vitamin D deficiency in patients presenting with hip fractures as Vitamin D deficiency is associated with suboptimal functional outcome in cases with hip fractures.

Downloads

Download data is not yet available.

References

Veronese N, Maggi S. Epidemiology and social costs of hip fracture. Injury 2018;49:1458-60.

Marks R, Allegrante JP, MacKenzie C, Lane JM. Hip fractures among the elderly: Causes, consequences and control. Ageing Res Rev 2003;2:57-93.

Gorter EA, Hamdy NA, Appelman-Dijkstra NM, Schipper IB. The role of vitamin D in human fracture healing: A systematic review of the literature. Bone 2014;64:288-97. doi: 10.1016/j.bone.2014.04.026

Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, et al. Vitamin D: Beyond bone. Ann N Y Acad Sci 2013;1287:45-58. doi: 10.1111/nyas.12129

Lips P, Netelenbos JC. Vitamin D deficiency and hip fracture. Tijdschr Gerontol Geriatr 1985;16:239-45.

Parizadeh SM, Rezayi M, Jafarzadeh-Esfehani R, Avan A, Ghazizadeh H, Emadzadeh M, et al. Association of vitamin D status with liver and kidney disease: A systematic review of clinical trials, and cross-sectional and cohort studies. Int J Vitam Nutr Res 2021;91:175-87.

Wiktorowicz ME, Goeree R, Papaioannou A, Adachi JD, Papadimitropoulos E. Economic implications of hip fracture: Health service use, institutional care and cost in Canada. Osteoporos Int 2001;12:271-8.

Segheto KJ, Pereira M, Silva DC, Carvalho CJ, Massardi FR, Kakehasi AM, et al. Vitamin D and bone health in adults: A systematic review and meta-analysis. Cien Saude Colet 2021;26:3221-44. doi: 10.1590/1413-81232021268.15012020

Kazley JM, Banerjee S, Abousayed MM, Rosenbaum AJ. Classifications in brief: Garden classification of femoral neck fractures. Clin Orthop Relat Res 2018;476:441-5. doi: 10.1007/s11999.0000000000000066 10. Vishwanathan K, Akbari K, Patel AJ. Is the modified Harris hip score valid and responsive instrument for outcome assessment in the Indian population with pertrochanteric fractures? J Orthop 2018;15:40-6. doi: 10.1016/j.jor.2017.12.001. PMID: 29326497

Alpantaki K, Papadaki C, Raptis K, Dretakis K, Samonis G, Koutserimpas C. Gender and Age differences in hip fracture types among elderly: A retrospective cohort study. Maedica (Bucur) 2020;15:185-90. doi: 10.26574/maedica.2020.15.2.185. PMID: 32952683

Hawkes WG, Wehren L, Orwig D, Hebel JR, Magaziner J. Gender differences in functioning after hip fracture. J Gerontol A Biol Sci Med Sci 2006;61:495-9. doi: 10.1093/gerona/61.5.495

Orwig DL, Chan J, Magaziner J. Hip fracture and its consequences: Differences between men and women. Orthop Clin North Am 2006;37:611-22. doi: 10.1016/j.ocl.2006.08.003

George J, Sharma V, Farooque K, Mittal S, Trikha V, Malhotra R. Injury mechanisms of hip fractures in India. Hip Pelvis 2021;33:62-70. doi: 10.5371/hp.2021.33.2.62

Endo Y, Aharonoff GB, Zuckerman JD, Egol KA, Koval KJ. Gender differences in patients with hip fracture: A greater risk of morbidity and mortality in men. J Orthop Trauma 2005;19:29-35.

Moayyeri A, Soltani A, Larijani B, Naghavi M, Alaeddini F, Abolhassani F. Epidemiology of hip fracture in Iran: Results from the Iranian multicenter study on accidental injuries. Osteoporos Int 2006;17:1252-7.

Ramason R, Selvaganapathi N, Ismail NH, Wong WC, Rajamoney GN, Chong MS. Prevalence of vitamin D deficiency in patients with hip fracture seen in an orthogeriatric service in sunny Singapore. Geriatr Orthop Surg Rehabil 2014;5:82-6. doi: 10.1177/2151458514528952

Bischoff-Ferrari HA, Can U, Staehelin HB, Platz A, Henschkowski J, Michel BA, et al. Severe vitamin D deficiency in Swiss hip fracture patients. Bone 2008;42:597-602.

Khadgawat R, Brar KS, Gahlo M, Yadav CS, Malhotra R, Guptat N, et al. High prevalence of vitamin D deficiency in Asian-Indian patients with fragility hip fracture: A pilot study. J Assoc Physicians India 2010;58:538-42.

Ingstad F, Solberg LB, Nordsletten L, Thorsby PM, Hestnes I, Frihagen F. Vitamin D status and complications, readmissions, and mortality after hip fracture. Osteoporos Int 2021;32:873-81. doi: 10.1007/s00198-020- 05739-9.

Published

07-09-2023

How to Cite

KARAN HINGANKAR, AVINASH KEDARI, RAJ PRAMOD GANDHI, and RAHIL JIWANI. “VITAMIN D STATUS AND ITS EFFECT ON FUNCTIONAL OUTCOME IN PATIENTS WITH HIP FRACTURE: AN OBSERVATIONAL STUDY”. Asian Journal of Pharmaceutical and Clinical Research, vol. 16, no. 9, Sept. 2023, pp. 171-4, doi:10.22159/ajpcr.2023v16i10.49260.

Issue

Section

Original Article(s)