ASSOCIATION OF HBA1C, SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR, INSULIN RESISTANCE IN PREDIABETES, DIABETES, AND DIABETIC RETINOPATHY PATIENTS

SOMA KRISHNAVENI; SUJATHA PASULA; PRAVEENA SABBANI

doi:10.22159/ajpcr.2023.v16i10.49297

Authors

SOMA KRISHNAVENI Department of Biochemistry, ESIC Medical College, Hyderabad, Telangana, India.
SUJATHA PASULA Department of Biochemistry, Osmania Medical College, Hyderabad, Telangana, India.
PRAVEENA SABBANI Department of Biochemistry, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i10.49297

Keywords:

Glycated hemoglobin, Serum vascular endothelial growth factor, Insulin resistance

Abstract

Background: In the micro- and macrovascular pathophysiology of diabetes mellitus, vascular endothelial growth factor (VEGF) is crucial. It has become recognized as a critical element contributing to the emergence of diabetes-related retinopathy and as a critical prognostic marker for the illness.

Aims: The aim of this study is to assess the level of glycated hemoglobin (HbA1c), serum VEGF, insulin resistance (IR) in prediabetes, type-2 diabetic patients without microvascular complications, and diabetic retinopathy patients

Methods: Values for serum VEGF, HbA1c, and IR were evaluated. Spearman coefficient correlation was used to perform the correlation.

Results: Our results demonstrate that fasting insulin levels were almost completely correlated with homeostasis model assessment index of IR (HOMA-IR) (r=0.99) and highly correlated with homeostasis model assessment of β-cell function (r= −0.84). We also looked at if there was any relationship between blood VEGF levels and biochemical results (HbA1c, total cholesterol, triglycerides, low-density lipoprotein). According to a study, IR and serum levels of VEGF were considerably greater in diabetic patients than in controls.

Conclusion: Both prediabetes and type 2 diabetes mellitus (T2DM) patients had elevated serum VEGF levels, and these individuals also had favorable relationships with their HOMA-IR scores. In comparison to controls, prediabetes and T2DM patients may have higher VEGF levels due to increased IR.

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