SERUM FERRITIN AND SERUM LACTATE DEHYDROGENASE LEVELS AMONG COVID-19 PATIENTS
DOI:
https://doi.org/10.22159/ajpcr.2024.v17i1.49572Keywords:
Covid-19, SARS-CoV-2, Ferritin, LDH, AOSD, Cytokine StormAbstract
Objectives: The aim of this study was to estimate serum ferritin and serum lactate dehydrogenase (LDH) values among COVID-19-positive and COVID-19-negative subjects.
Methods: The study was conducted on 152 cases; 76 were COVID-19 diseased, and 76 were COVID-19 free. Serum ferritin and serum LDH levels were estimated.
Result: Average ferritin levels among COVID-19 diseased were 529.33 ng/ml compared to 450.92 ng/ml among negative individuals. Similarly, the LDH level among positive persons was 338.50 IU/L and 303.30 IU/L among hostile people.
Conclusion: The uncontrolled and dysfunctional immune response is connected with macrophage activation and hyperferritinemic syndrome. Elevated LDH readings seem to reflect that multiple organ injury and failure may play a more prominent role in influencing the clinical outcomes in patients with COVID-19.
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Jiang Y, Rubin L, Peng T, Liu L, Xing X, Lazarovici P, et al. Cytokine storm in COVID-19: From viral infection to immune responses, diagnosis and therapy. Int J Biol Sci 2022;18:459-72. doi: 10.7150/ ijbs.59272, PMID 35002503
Lei J, Kusov Y, Hilgenfeld R. Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein. Antiviral Res 2018;149:58- 74. doi: 10.1016/j.antiviral.2017.11.001, PMID 29128390
Kaftan AN, Hussain MK, Algenabi AA, Naser FH, Enaya MA. Predictive value of C-reactive protein, lactate dehydrogenase, ferritin and D-dimer levels in diagnosing COVID-19 patients: A retrospective study. Acta Inform Med 2021;29:45-50. doi: 10.5455/aim.2021.29.45- 50, PMID 34012213
Cheng L, Li H, Li L, Liu C, Yan S, Chen H, et al. Ferritin in the coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. J Clin Lab Anal 2020;34:e23618. doi: 10.1002/jcla.23618, PMID 33078400
Oreshkova N, Molenaar RJ, Vreman S, Harders F, Oude Munnink BB, Hakze-van der Honing RW, et al. SARS-CoV-2 infection in farmed minks, the Netherlands, April and May 2020. Euro Surveill 2020;25:2001005. doi: 10.2807/1560-7917.ES.2020.25.23.2001005, PMID 32553059
Davies NG, Barnard RC, Jarvis CI, Russell TW, Semple MG, Jit M, et al. Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: A modelling study. Lancet Infect Dis 2021;21:482-92. doi: 10.1016/S1473- 3099(20)30984-1, PMID 33357518
Feld J, Tremblay D, Thibaud S, Kessler A, Naymagon L. Ferritin levels in patients with COVID‐19: A poor predictor of mortality and hemophagocytic lymphohistiocytosis. Int J Lab Hematol 2020;42:773- 9. doi: 10.1111/ijlh.13309, PMID 32790918
Challen R, Brooks-Pollock E, Read JM, Dyson L, Tsaneva- Atanasova K, Danon L. Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: Matched cohort study. BMJ 2021;372:n579. doi: 10.1136/bmj.n579, PMID 33687922
Davies NG, Jarvis CI, Edmunds WJ, Jewell NP, Diaz-Ordaz K, Keogh RH. Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7. Nature 2021;593:270-4.
Grint DJ, Wing K, Williamson E, McDonald HI, Bhaskaran K, Evans D, et al. Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February. Euro Surveill 2021;26:2100256.
Tegally H, Wilkinson E, Giovanetti M, Iranzadeh A, Fonseca V, Giandhari J, et al. Detection of a SARS-CoV-2 variant of concern in South Africa. Nature 2021;592:438-43. doi: 10.1038/s41586-021- 03402-9, PMID 33690265
Wibmer CK, Ayres F, Hermanus T, Madzivhandila M, Kgagudi P, Oosthuysen B, et al. SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. Nat Med 2021;27:622-5. doi: 10.1038/s41591-021-01285-x, PMID 33654292
Mwenda M, Saasa N, Sinyange N, Busby G, Chipimo PJ, Hendry J, et al. Detection of B.1.351 SARS-CoV-2 Variant Strain - Zambia, December 2020. MMWR Morb Mortal Wkly Rep 2021;70:280-2. doi: 10.15585/mmwr.mm7008e2, PMID 33630820
Ruscitti P, Berardicurti O, Di Benedetto P, Cipriani P, Iagnocco A, Shoenfeld Y, et al. Severe COVID-19, another piece in the puzzle of the hyperferritinemic syndrome. An immunomodulatory perspective to alleviate the storm. Front Immunol 2020;11:1130. doi: 10.3389/ fimmu.2020.01130, PMID 32574264
Perricone C, Bartoloni E, Bursi R, Cafaro G, Guidelli GM, Shoenfeld Y, et al. COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy. Immunol Res 2020;68:213-24. doi: 10.1007/ s12026-020-09145-5, PMID 32681497
Biryukov J, Boydston JA, Dunning RA, Yeager JJ, Wood S, Ferris A, et al. SARS-CoV-2 is rapidly inactivated at high temperatures. Environ Chem Lett 2021;19:1773-7. doi: 10.1007/s10311-021-01187-x, PMID 33551702
Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med 2020;26:450-2. doi: 10.1038/s41591-020-0820-9, PMID 32284615
Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, et al. Tracking changes in SARS-CoV-2 Spike: Evidence that D614G increases infectivity of the COVID-19 virus. Cell 2020;182:812-27. e19. doi: 10.1016/j.cell.2020.06.043
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