A CASE REPORT ON STENOTROPHOMONAS MALTOPHILIA

Authors

  • VIJETA SHARMA Department of Microbiology, Mahaveer Institute of Medical sciences, Bhopal, Madhya Pradesh, India https://orcid.org/0000-0001-6550-0725
  • SATENDRA SARASWAT Department of Microbiology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India. https://orcid.org/0000-0002-0088-8877
  • VIJAYLAXMI SHARMA Department of Anatomy, SMS Medical College, Jaipur, India
  • PREETI CHAUHAN Technologist, Scientific Pathology, Agra, Uttar Pradesh, India

DOI:

https://doi.org/10.22159/ajpcr.2024.v17i5.49632

Keywords:

Gram-negative bacilli, Community-acquired pneumonia, Empiric antibiotic treatment

Abstract

Stenotrophomonas maltophilia is stated as the Gram-negative bacterium that is often resistant to multiple antibiotics. It is among the most common cause of community-acquired pneumonia in patients with underlying medical conditions, such as diabetes and hypertension. In this case, the patient’s pneumonia did not respond to empiric antibiotic treatment with ceftriaxone and azithromycin. However, his symptoms resolved after treatment with levofloxacin. This case report highlights the importance of considering S. maltophilia in the differential diagnosis of community-acquired pneumonia in patients with underlying medical conditions. Sputum culture with an antibiogram is essential for making the diagnosis and selecting appropriate antibiotic treatment.

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References

Senol E. Stenotrophomonas maltophilia: The significance and role as a nosocomial pathogen. J Hosp Infect. 2004;57(1):1-7. doi: 10.1016/j. jhin.2004.01.033, PMID 15142709

Muder RR, Yu VL, Dummer JS, Vinson C, Lumish RM. Infections caused by Pseudomonas maltophilia. Expanding clinical spectrum. Arch Intern Med. 1987;147:1672-4.

Calza L, Manfredi R, Chiodo F. Stenotrophomonas (Xanthomonas) maltophilia as an emerging opportunistic pathogen in association with HIV infection: A 10-year surveillance study. Infection. 2003;31(3):155- 61. doi: 10.1007/s15010-003-3113-6, PMID 12789473

Cernohorská L, Votava M. Determination of minimal regrowth concentration (MRC) in clinical isolates of various biofilm-forming bacteria. Folia Microbiol (Praha). 2004;49(1):75-8. doi: 10.1007/ BF02931650, PMID 15114870

Yeshurun M, Gafter-Gvili A, Thaler M, Keller N, Nagler A, Shimoni A. Clinical characteristics of Stenotrophomonas maltophilia infection in hematopoietic stem cell transplantation recipients: A single center experience. Infection. 2010;38(3):211-5. doi: 10.1007/s15010- 010-0023-2, PMID 20425134

Hentrich M, Schalk E, Schmidt-Hieber M, Chaberny I, Mousset S, Buchheidt D, et al. Central venous catheter-related infections in hematology and oncology: 2012 updated guidelines on diagnosis, management and prevention by the infectious diseases working party of the German society of hematology and medical oncology. Ann Oncol. 2014;25:936-47. doi: 10.1093/annonc/mdt545

Gnanasekaran S, Bajaj R. Stenotrophomonas maltophilia bacteremia in end-stage renal disease patients receiving maintenance hemodialysis. Dial Transplant. 2009;38:30-2. doi: 10.1002/dat.20276

De Oliveira-Garcia D, Dall’Agnol M, Rosales M, Azzuz AC, Alcántara N, Martinez MB, et al. Fimbriae and adherence of Stenotrophomonasmaltophilia to epithelial cells and to abiotic surfaces. Cell Microbiol. 2003;5:625-36. doi: 10.1046/j.1462-5822.2003.00306.x

Brooke JS. Stenotrophomonas maltophilia: An emerging global opportunistic pathogen. Clin Microbiol Rev. 2012;25(1):2-41. doi: 10.1128/CMR.00019-11, PMID 22232370

Safdar A, Rolston KV. Stenotrophomonas maltophilia: Changing spectrum of a serious bacterial pathogen in patients with cancer. Clin Infect Dis. 2007;45(12):1602-9. doi: 10.1086/522998, PMID 18190323

Willsey GG, Eckstrom K, LaBauve AE, Hinkel LA, Schutz K, Meagher RJ, et al. Stenotrophomonas maltophilia differential gene expression in synthetic cystic fibrosis sputum reveals shared and cystic fibrosis strain-specific responses to the sputum environment. J Bacteriol. 2019;201(15):e00074-19. doi: 10.1128/JB.00074-19, PMID 31109991

Looney WJ, Narita M, Mühlemann K. Stenotrophomonas maltophilia: An emerging opportunist human pathogen. Lancet Infect Dis. 2009;9(5):312-23. doi: 10.1016/S1473-3099(09)70083-0, PMID 19393961

Nicodemo AC, Paez JI. Antimicrobial therapy for Stenotrophomonas maltophilia infections. Eur J Clin Microbiol Infect Dis. 2007;26(4):229-37. doi: 10.1007/s10096-007-0279-3, PMID 17334747

Matson HH, Jones BM, Wagner JL, Motes MA, Bland CM. Growing resistance in Stenotrophomonas maltophilia? Am J Health Syst Pharm. 2019 2;76(24):2004-5. doi: 10.1093/ajhp/zxz247, PMID 31789358

Abbott IJ, Slavin MA, Turnidge JD, Thursky KA, Worth LJ. Stenotrophomonas maltophilia: Emerging disease patterns and challenges for treatment. Expert Rev Anti Infect Ther. 2011;9(4):471-88. doi: 10.1586/eri.11.24, PMID 21504403

Weiss K, Restieri C, De Carolis E, Laverdière M, Guay H. Comparative activity of new quinolones against 326 clinical isolates of Stenotrophomonas maltophilia. J Antimicrob Chemother. 2000;45(3):363-5. doi: 10.1093/jac/45.3.363, PMID 10702558

Watson L, Esterly J, Jensen AO, Postelnick M, Aguirre A, McLaughlin M. Sulfamethoxazole/trimethoprim versus fluoroquinolones for the treatment of Stenotrophomonas maltophilia bloodstream infections. J Glob Antimicrob Resist. 2018;12:104-6. doi: 10.1016/j.jgar.2017.09.015, PMID 28964955

Jacobson S, Junco Noa L, Wallace MR, Bowman MC. Clinical outcomes using minocycline for Stenotrophomonas maltophilia infections. J Antimicrob Chemother. 2016;71(12):3620. doi: 10.1093/ jac/dkw327, PMID 27516472

Gales AC, Reis AO, Jones RN. Contemporary assessment of antimicrobial susceptibility testing methods for polymyxin B and colistin: Review of available interpretative criteria and quality control guidelines. J Clin Microbiol. 2001;39(1):183-90. doi: 10.1128/ JCM.39.1.183-190.2001, PMID 11136768

Doi Y. Treatment options for carbapenem-resistant Gram-negative bacterial infections. Clin Infect Dis. 2019 13;69(Suppl 7):S565- 75. doi: 10.1093/cid/ciz830, PMID 31724043

Hu LF, Gao LP, Ye Y, Chen X, Zhou XT, Yang HF, et al. Susceptibility of Stenotrophomonas maltophilia clinical strains in China to antimicrobial combinations. J Chemother. 2014;26(5):282-6. doi: 10.1179/1973947814Y.0000000168, PMID 24588423

Gil-Gil T, Martínez JL, Blanco P. Mechanisms of antimicrobial resistance in Stenotrophomonas maltophilia: A review of current knowledge. Expert Rev Anti Infect Ther. 2020;18(4):335-47. doi: 10.1080/14787210.2020.1730178, PMID 32052662

Published

07-05-2024

How to Cite

SHARMA, V., S. SARASWAT, V. SHARMA, and P. CHAUHAN. “A CASE REPORT ON STENOTROPHOMONAS MALTOPHILIA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 17, no. 5, May 2024, pp. 5-7, doi:10.22159/ajpcr.2024.v17i5.49632.

Issue

Section

Case Study(s)