ANTI-INFLAMMATORY, ANALGESIC AND ANTI - PYRETIC ACTIVITY OF CASSAVA LEAVES EXTRACT
Abstract
Objective: The objective of this study was to evaluate the in-vivoanti-inflammatory, anti pyretic and analgesic activities and phytochemical analysis of cassava leaf extract.
Material and method:The leaf extract was prepared with ethanol filter and rotary evaporated and stored in desiccator.Preliminary phytochemical screening terpernoids, tannins, flavonoids, anthraquinones, alkaloids, and cardiac glycosides and carotenoids were carried out. A different concentration (100,250,500mg/kg) of the leaf extract was evaluated for their anti-inflammary, analgesic and anti-pyretic effect using carrageenan and histamine induced oedema, acetic acid induced writhing and yeast induced pyrexia in rats respectively.
Result and Conclusion: The extract at concentration100, 250,500mg/kg was able to inhibit carrageenan and histamine induced oedema,acetic acid induced writhing and yeast induced pyrexia in rats. Terpernoids, tannins, flavonoids,carotenoids were found present in the cassava leaf extract.
key words: cassava leaves, anti-inflammatory, anti pyretic, analgesic, phytochemicals
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