DIAGNOSTIC METHODS FOR NON-ALCOHOLIC FATTY LIVER DISEASES ALTERNATIVE TO LIVER BIOPSY: A REVIEW
Abstract
Non-alcoholic fatty liver diseases (NAFLD) are the most occurring chronic liver diseases caused by hepatic manifestation of metabolic syndromes
like insulin resistance in Type-2 diabetes, obesity and hyperlipidemic condition. Indian men have a high prevalence of NAFLD. Genetic factor is also
an important consideration for NAFLD. The core aim of this study is to focus on non-invasive biochemical markers for diagnosis of NAFLD as an
alternative to liver biopsy. Biopsy is the gold standard for NAFLD; however a variety of studies powerfully suggest that due to the limitation and risk
of biopsy, as well as improvement of the diagnostic accuracy of biochemical markers, biopsy should no longer be considered obligatory. Thus, due to
the limitation of liver biopsy, numerous biomarkers has been developed recently, which may provide more accurate results than an inferior quality
liver biopsy. Some important biomarkers are caspase-cleaved cytokeratin-18, breath biomarker, circulating microRNAs, abdominal ultrasound,
adipocytokines, etc.
Keywords: Adipocytokines, Cytokeratin-18, Liver biopsy, MicroRNAs, Non-alcoholic fatty liver diseases, Non-invasive biomarkers
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