TO STUDY THE EFFICACY OF TROPICAL APPLICATION OF CANNABIS IN CHRONIC KNEE JOINT PAIN PATIENTS
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i12.49934Keywords:
Chronic knee joint pain, Cannabis oil, Osteoarthritis.Abstract
Objectives: The objective of this study was to study the decrease in pain at specified time intervals after tropical application of cannabis oil in chronic joint pain patients and to study the change in the visual analog score (VAS) and numeric rating scale (NRS) scoring of patient’s pain before and after the application.
Methods: Patients were pre-informed about the process. VAS and NRS scores were noted before tropical application of the Cannabis oil. Cannabis oil was applied tropically on patients with chronic joint pain on the specified site, that is, B/L knee joints. Then, the decrease in the severity of pain at specific time interval was recorded on the pre-set pro forma. The VAS score and NRS score were recorded 30 min after the application. The final data were represented in the form of tables and graphs.
Results: The mean improvement values at 0–5 min, 5–10 min, 15–20 min, and 20–30 min were 35.90%, 41.80%, 47.90%, and 56.50%, respectively. The mean VAS score before application 7.00 reduced significantly to 2.32 after 30 min of application (p<0.05). Similarly, the mean NRS score also reduced significantly to 2.52 from mean value 7.08 at before application (p<0.05), that is, pain is significantly reduced.
Conclusion: From the data analysis, we reach to the conclusion that tropical application of Cannabis oil is effective in B/L knee joint osteoarthritis chronic pain.
Downloads
References
Siripongpan A, Sindhupakorn B. A Comparative study of osteoarthritic knee patients between urban and rural areas in knee severity and quality of life. Health Psychol Res 2022;10:35466. doi: 10.52965/001c.35466
Creamer P, Lethbridge-Cejku M, Hochberg MC. Factors associated with functional impairment in symptomatic knee osteoarthritis. Rheumatology (Oxford) 2000;39:490-6. doi: 10.1093/ rheumatology/39.5.490, PMID 10852978
Helmick CG, Felson DT, Lawrence RC, Gabriel S, Hirsch R, Kwoh CK, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part I. Arthritis Rheum 2008;58:15-25. doi: 10.1002/art.23177, PMID 18163481
Fransen M, Bridgett L, March L, Hoy D, Penserga E, Brooks P. The epidemiology of osteoarthritis in Asia. Int J Rheum Dis 2011;14:113-21. doi: 10.1111/j.1756-185X.2011.01608.x, PMID 21518309
Cho HJ, Chang CB, Kim KW, Park JH, Yoo JH, Koh IJ, et al. Gender and prevalence of knee osteoarthritis types in elderly Koreans. J Arthroplasty 2011;26:994-9. doi: 10.1016/j.arth.2011.01.007, PMID 21414750
Clark PA, Capuzzi K, Fick C. Medical marijuana: Medical necessity versus political agenda. Med Sci Monit 2011;17:RA249-61. doi: 10.12659/msm.882116, PMID 22129912
Rolsson P. Cannabis as medicine: time for the phoenix to rise. BMJ 1998;316:1034-5.
Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990;346:561-4. doi: 10.1038/346561a0, PMID 2165569
Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993;365:61-5. doi: 10.1038/365061a0, PMID 7689702
Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, et al. International union of pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 2002;54:161-202. doi: 10.1124/ pr.54.2.161, PMID 12037135
Pertwee RG. Cannabinoid receptors and pain. Prog Neurobiol 2001;63:569-611. doi: 10.1016/s0301-0082(00)00031-9, PMID 11164622
Jhaveri MD, Richardson D, Chapman V. Endocannabinoid metabolism and uptake: Novel targets for neuropathic and inflammatory pain. Br J Pharmacol 2007;152:624-32. doi: 10.1038/sj.bjp.0707433, PMID 17704819
Rea K, Roche M, Finn DP. Supraspinal modulation of pain by cannabinoids: The role of GABA and glutamate. Br J Pharmacol 2007;152:633-48. doi: 10.1038/sj.bjp.0707440, PMID 17828292
Pertwee R. Pharmacological actions of cannabinoids. Handb Exp Pharmacol 2005;168:1-37.
Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, et al. Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci 2007;10:870-9. doi: 10.1038/nn1916, PMID 17558404
Rukwied R, Watkinson A, McGlone F, Dvorak M. Cannabinoid agonists attenuate capsaicin-induced responses in human skin. Pain 2003;102:283-8. doi: 10.1016/S0304-3959(02)00401-3, PMID 12670670
Walker JM, Hohmann AG. Cannabinoid mechanisms of pain suppression. Handb Exp Pharmacol 2005;168:509-54. doi: 10.1007/3- 540-26573-2_17, PMID 16596786
Guindon J, Hohmann AG. Cannabinoid CB2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain. Br J Pharmacol 2008;153:319-34. doi: 10.1038/sj.bjp.0707531, PMID 17994113
Hame SL, Alexander RA. Knee osteoarthritis in women. Curr J Musculoskelet Med 2013;6:182-7.
Mahajan A, Patni R. Menopause and osteoarthritis: Any association? J Mid Life Health 2018;9:171-2. doi: 10.4103/jmh.JMH_157_18, PMID 30692810
Published
How to Cite
Issue
Section
Copyright (c) 2023 Dr. Dileep Dandotiya
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.