CLINICAL AND HEMATOLOGICAL PROFILE OF PATIENTS WITH DENGUE FEVER AT A TERTIARY CARE HOSPITAL: AN OBSERVATIONAL STUDY

BASAVARAJ GT; AVINASH ALASHETTY; CHANNAMMA G

doi:10.22159/ajpcr.2023.v16i11.50117

Authors

BASAVARAJ GT Department of General Medicine, M R Medical College, Kalaburagi, Karnataka, India.
AVINASH ALASHETTY Department of General Medicine, M R Medical College, Kalaburagi, Karnataka, India
CHANNAMMA G Department of General Medicine, M R Medical College, Kalaburagi, Karnataka, India

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i11.50117

Keywords:

Dengue fever, Clinical Picture, Haematological Profile, Outcome

Abstract

Objectives: The objective of this study was to analyze the clinical and hematological profile and studying outcome of patients having dengue fever (DF).

Methods: This was an observational study conducted in the Department of General Medicine, Basveshwar Teaching and General Hospital, Kalaburagi, India. One hundred patients with DF were included in this study. Demographic details were obtained, detailed history was taken, and clinical examination was done. The cases were classified into dengue without warning signs, dengue with warning signs, and severe dengue as per world health organization classification of dengue. Clinical features, hematological profile, and outcome were assessed in studied cases. SSPE 21 software was used for statistical analysis. P value less than 0.05 was taken as statistically significant.

Results: Out of these 100 cases, there were 62 (62.00 %) males and 38 (38 %) females with a M: F ratio of 1: 0.61. The mean age of male and female patients was found to be comparable with no statistically significant difference in the age group (p=0.391). Out of 100 studied cases, non-severe dengue was seen in 56 (56%) patients whereas 31 (31.00%) patients had non-severe dengue with warning signs and remaining 13 (13.00%) patients had severe dengue. The most common presenting complaint was fever which was present in all patients (100%). The other complaints included headache (82%) nausea and vomiting (74%). Positive torniquet test was seen in 7 (7%) patients and hypotension, decreased pulse pressure, and altered sensorium were seen in 5 (5%) patients each. In cases of dengue with warning signs or severe dengue out of 44 patients, 21 (21%) patients required blood component therapy and 5 (5%) patients landed up in shock despite fluid therapy. Two (2%) succumbed to complications of severe dengue.

Conclusion: Comprehensive understanding of clinical features, hematological profile, and warning signs in DF is essential for timely diagnosis and effective management. With early diagnosis and proper management, the outcome of patients is usually good.

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References

Murray NE, Quam MB, Wilder-Smith A. Epidemiology of dengue: Past, present and future prospects. Clin Epidemiol 2013;5:299-309. doi: 10.2147/CLEP.S34440, PMID: 23990732; PMCID: PMC3753061

Fernandes-Santos C, Azeredo EL. Innate immune response to dengue virus: Toll-like receptors and antiviral response. Viruses 2022;14:992. doi: 10.3390/v14050992, PMID: 35632732; PMCID: PMC9147118

Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 1998;11:480-96. doi: 10.1128/CMR.11.3.480, PMID: 9665979; PMCID: PMC88892

Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, et al. Dengue hemorrhagic fever - a systemic literature review of current perspectives on pathogenesis, prevention and control. J Microbiol Immunol Infect 2020;53:963-78. doi: 10.1016/j. jmii.2020.03.007, PMID: 32265181

Tsheten T, Clements AC, Gray DJ, Adhikary RK, Furuya-Kanamori L, Wangdi K. Clinical predictors of severe dengue: A systematic review and meta-analysis. Infect Dis Poverty 2021;10:123. doi: 10.1186/ s40249-021-00908-2, PMID: 34627388; PMCID: PMC8501593

Ferraz FO, Bomfim MR, Totola AH, Ávila TV, Cisalpino D, Pessanha JE, et al. Evaluation of laboratory tests for dengue diagnosis in clinical specimens from consecutive patients with suspected dengue in Belo Horizonte, Brazil. J Clin Virol 2013;58:41-6. doi: 10.1016/j. jcv.2013.06.015, PMID: 23871166

Chow VT. Molecular diagnosis and epidemiology of dengue virus infection. Ann Acad Med Singapore 1997;26:820-6. PMID: 9522986

Schexneider KI, Reedy EA. Thrombocytopenia in dengue fever. Curr Hematol Rep 2005;4:145-8. PMID: 15720964

Rajapakse S, Rodrigo C, Rajapakse A. Treatment of dengue fever. Infect Drug Resist. 2012;5:103-12. doi: 10.2147/IDR.S22613, PMID: 22870039; PMCID: PMC3411372

Kalayanarooj S. Clinical manifestations and management of dengue/ DHF/DSS. Trop Med Health 2011;39(4 Suppl):83-7. doi: 10.2149/ tmh.2011-S10, PMID: 22500140; PMCID: PMC3317599

Kalayanarooj S. Dengue classification: Current WHO vs. the newly suggested classification for better clinical application? J Med Assoc Thai 2011;94(Suppl 3):S74-84. PMID: 22043757

Chhotala YH, Suva CM. A study of clinical profile of dengue fever in a tertiary care hospital of Jamnagar, Gujarat, India. Int J Res Med Sci 2016;4:4500-4.

Kumar M, Verma RK, Mishra B. Prevalence of dengue fever in western Uttar Pradesh, India: A gender-based study. Int J Appl Basic Med Res 2020;10:8-11. doi:10.4103/ijabmr.IJABMR_337_18

Anker M, Arima Y. Male-female differences in the number of reported incident dengue fever cases in six Asian countries. Western Pac Surveill Response J 2011;2:17-23. doi:10.5365/WPSAR.2011.2.1.002

Deshkar ST, Raut SS, Khadse RK. Dengue infection in central India: A 5 years study at a tertiary care hospital. Int J Res Med Sci 2017;5:2483-9. doi:10.18203/2320-6012.ijrms20172433

Saini S, Kinikar AG, Deorukhkar S, Bhalerao D, Roushani SB. Epidemiology and seropositivity of dengue fever cases in a rural tertiary care hospital of western Maharashtra, India. Int J Bio Med Res 2013;4:473-7.

Karoli R, Fatima J, Siddiqi Z, Kazmi K, Sultania A. Clinical profile of dengue in India. J Infect Dev Ctries 2012;6:551-4.

Zerfu B, Kassa T, Legesse M. Epidemiology, biology, pathogenesis, clinical manifestations, and diagnosis of dengue virus infection, and its trend in Ethiopia: A comprehensive literature review. Trop Med Health 2023;51:11. doi:10.1186/s41182-023-00504-0

Hasan SR, Riaz M, Jafri FA. Characteristics and outcome of dengue infection; clinical perspective from a secondary care hospital of Karachi. Pak J Med Sci 2013;29:115-8. doi:10.12669/pjms.291.2742

Kulkarni AV, Choudhury AK, Premkumar M, Jain P, Gupta E, Sarin SK. Spectrum, manifestations and outcomes of dengue infection in individuals with and without liver disease. J Clin Transl Hepatol 2019;7:106-11. doi:10.14218/JCTH.2018.00047