TO STUDY ASSOCIATION OF OBESITY WITH HORMONAL IMBALANCE IN PRIMARY INFERTILITY AND EARLY PREGNANCY LOSS

JASVIR SINGH; SEEMA; MANINDER KAUR; MANJIT KAUR MOHI

doi:10.22159/ajpcr.2024.v17i6.50667

Authors

JASVIR SINGH Department of Biochemistry, Government Medical College, Patiala, Punjab, India
SEEMA Department of Biochemistry, Government Medical College, Patiala, Punjab, India https://orcid.org/0000-0003-0961-8643
MANINDER KAUR Department of Biochemistry, Government Medical College, Patiala, Punjab, India
MANJIT KAUR MOHI Department of Obstetrics and Gynaecology, Government Medical College, Patiala, Punjab, India.

DOI:

https://doi.org/10.22159/ajpcr.2024.v17i6.50667

Keywords:

Follicle-stimulating hormone, Luteinizing hormone, Prolactin, Thyroid-stimulating hormone, Body mass index, Early pregnancy loss

Abstract

Objectives: The study aimed to assess follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, and thyroid-stimulating hormone in obese patients with primary infertility and early pregnancy loss (EPL) and compare with normal fertile patients.

Methods: Patients were divided into two groups. Group A consists of 50 patients with a history of infertility and EPL with a body mass index of more than 30 kg/m2. Group B consists of 50 normal fertile patients. Informed written consent was taken from all the patients. Blood samples were taken and hormone levels in two groups were measured and compared statistically.

Results: Comparison and statistical analysis of FSH levels in obese infertile and normal fertile groups showed the difference to be statistically highly significant. LH levels in both groups were statistically highly significant. When compared statistically, the difference between prolactin levels of both groups was highly significant.

Conclusion: This study supports the impact of obesity on infertility and pregnancy outcomes. Obesity affects dysfunction of the hypothalamus, pituitary ovarian axis, and results in a higher risk of infertility and EPL.

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Author Biography

MANINDER KAUR, Department of Biochemistry, Government Medical College, Patiala, Punjab, India

References

Available from: https://www.nhp.gov.in/disease/gynaecology-and-obstetrics/early-pregnancy-loss

Goldsammler M, Merhi Z, Buyuk E. Role of hormonal and inflammatory alterations in obesity-related reproductive dysfunction at the level of the hypothalamic-pituitary-ovarian axis. Reprod Biol Endocrinol. 2018;16(1):45. doi: 10.1186/s12958-018-0366-6, PMID 29743077

Bheem P, Dinesh P, Sharma NC. A study on serum FSH, LH and prolactin levels among infertile women. Int J Med Res Health Sci. 2015;4:876-8.

World Health Organization. Obesity: Preventing and Managing the Global Eepidemic. WHO Obesity Technical Report Series. Vol. 2000. Geneva: WHO; 2000.

Haslam DW, James WP. Obesity. Lancet. 2005;366(9492):1197-209. doi: 10.1016/S0140-6736(05)67483-1

Pandey S, Pandey S, Maheshwari A, Bhattacharya S. The impact of female obesity on the outcome of fertility treatment. J Hum Reprod Sci. 2010;3(2):62-7. doi: 10.4103/0974-1208.69332, PMID 21209748

Gupta RD, Tamanna N, Siddika N, Haider SS, Apu EH, Haider MR. Obesity and abdominal obesity in Indian population: Findings from a nationally representative study of 698,286 participants. Epidemiologia (Basel). 2023 May 12;4(2):163-72. doi: 10.3390/ epidemiologia4020017, PMID: 37218876, PMCID: PMC10204471

Seth B, Arora S, Singh R. Association of obesity with hormonal imbalance in infertility: A cross-sectional study in north Indian women. Indian J Clin Biochem. 2013 Oct;28(4):342-7. doi: 10.1007/s12291- 013-0301-8, PMID: 24426235, PMCID: PMC3783913

Gautam D, Purandare N, Maxwell CV, Rosser ML, O’Brien P, Mocanu E, et al. The challenges of obesity for fertility: A FIGO literature review. Int J Gynaecol Obstet. 2023;160(Suppl 1):50-5. doi: 10.1002/ijgo.14538, PMID 36635080

Dardar H, Abdulla S, Abdulrazeg A, Elhddad A. Association of BMI and hormonal imbalance with primary and secondary infertility: A cross-sectional study. Alq J Med App Sci. 2022;5(2):565-72.

Nelson OE, Chukwuma EF. Association of body mass index with hypothalamus-pituitary-ovarian axis hormones in infertile women in the Niger Delta region, Nigeria. Open J Obstetr Gynecol. 2022;12(8):671-85. doi: 10.4236/ojog.2022.128060

Baraskar K, Thakur P, Shrivastava R, Shrivastava VK. Female obesity: Association with endocrine disruption and reproductive dysfunction. Obes Med. 2021;28:100375.

Silvestris E, De Pergola G, Rosania R, Loverro G. Obesity as disruptor of the female fertility. Reprod Biol Endocrinol. 2018;16(1):22. doi: 10.1186/s12958-018-0336-z, PMID 29523133

Dağ ZÖ, Dilbaz B. Impact of obesity on infertility in women. J Turk Ger Gynecol Assoc. 2015 Jun 1;16(2):111-7. doi: 10.5152/ jtgga.2015.15232, PMID 26097395