CLINICAL PROFILE AND PREGNANCY OUTCOMES OF COVID POSITIVE PREGNANT WOMEN IN PHASE I ANDII INFECTION – A COMPARATIVE STUDY

Authors

  • DEEPTHI PS Department of Obstetrics and Gynecology, Government T D Medical College, Alappuzha, Kerala, India.
  • SATHIAMMA PK Department of Obstetrics and Gynecology, Government T D Medical College, Alappuzha, Kerala, India.

DOI:

https://doi.org/10.22159/ajpcr.2024v17i7.51090

Keywords:

First and second phases, Antenatal complications and comorbidities, Neonatal outcome, Maternal outcome,, Coronavirus disease 2019 infection

Abstract

Objectives: This study aims to assess the clinical features, the impact of coronavirus disease 2019 (COVID-19) infection during pregnancy, and the perinatal and obstetric outcomes in phases I and II.

Methods: The current study was performed from January 2020 to August 2021 at the Government T D Medical College, Alappuzha. The pregnant women were registered instantly after each infected woman was known as per the inclusion and exclusion criteria. Demographic parameters, related comorbid disorders, intensive care unit admission, and complete treatment details of each woman were noted. Neonatal outcomes were documented.

Results: There were 254 women in wave 1 and 164 women in wave 2 in the obstetric admissions. Still was seen in 3 cases (wave 1) and 2 cases (wave 2). In both phases, most pregnant women fall under the age category between 21 and 30. Multi-parity was found to be 50.8% in wave 1 women and 59.2% in wave 2 women were common in both waves. The period of gestation and obstetric comorbidities were found to be statistically significant with a p=0.007 (phase I) and 0.008 (phase II).

Conclusion: Pregnancy-related COVID-19 infection may increase the threat of maternal death but has no influence on the morbidity and death of newborns. It is not possible to totally rule out the possibility of maternal-fetal transfer. Every wave of COVID-19 may have different characteristics and severity; therefore, our treatment plans must change. To confirm this transmission, more research or meta-analysis reports are needed.

Downloads

Download data is not yet available.

References

World Health Organization. Coronavirus Disease 2019 (COVID-19) Situation Report-52. Geneva: World Health Organization; 2020.

Liang H, Acharya G. Novel corona virus disease (COVID-19) in pregnancy: What clinical recommendations to follow? Acta Obstet Gynecol Scand. 2020;99(4):439-42. doi: 10.1111/aogs.13836, PMID: 32141062.

Nelson‐Piercy C. Handbook of Obstetric Medicine. New York: CRC Press; 2015. p. 371.

Van Well GT, Daalderop LA, Wolfs T, Kramer BW. Human perinatal immunity in physiological conditions and during infection. Mol Cell Pediatr. 2017;4(1):4. doi: 10.1186/s40348-017-0070-1, PMID: 28432664

The Guardian. India’s Shocking Surge in COVID Cases Follows Baffling Decline. London: The Guardian; 2021.

Nayak AH, Kapote DS, Fonseca M, Chavan N, Mayekar R, Sarmalkar M, et al. Impact of the coronavirus infection in pregnancy: A preliminary study of 141 patients. J Obstet Gynaecol India. 2020;70(4):256-61. doi: 10.1007/s13224-020-01335-3, PMID: 32760169

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. doi: 10.1001/jama.2020.1585, PMID: 32031570

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet. 2020;395(10223):507-13. doi: 10.1016/S0140-6736(20)30211-7, PMID: 32007143

Mullins E, Hudak ML, Banerjee J, Getzlaff T, Townson J, Barnette K, et al. Pregnancy and neonatal outcomes of COVID-19: Coreporting of common outcomes from PAN-COVID and AAP-SONPM registries. Ultrasound Obstet Gynecol. 2021;57(4):573-81. doi: 10.1002/ uog.23619, PMID: 33620113

Fan C, Lei D, Fang C, Li C, Wang M, Liu Y, et al. Perinatal transmission of 2019 coronavirus disease-associated severe acute respiratory syndrome coronavirus 2: Should we worry? Clin Infect Dis. 2021;72(5):862-4. doi: 10.1093/cid/ciaa226, PMID: 32182347

Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records. Lancet. 2020;395(10226):809-15. doi: 10.1016/ S0140-6736(20)30360-3, PMID: 32151335

Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: A retrospective, single-centre, descriptive study. Lancet Infect Dis. 2020;20(5):559-64. doi: 10.1016/S1473-3099(20)30176-6, PMID: 32220284

Qiancheng X, Jian S, Lingling P, Lei H, Xiaogan J, Weihua L, et al. Coronavirus disease 2019 in pregnancy. Int J Infect Dis. 2020;95:376-83. doi: 10.1016/j.ijid.2020.04.065, PMID: 32353549

Schwartz DA, Graham AL. Potential maternal and infant outcomes from (Wuhan) coronavirus 2019-nCoV infecting pregnant women: Lessons from SARS, MERS, and other human coronavirus infections. Viruses. 2020;12(2):194. doi: 10.3390/v12020194, PMID: 32050635

Creanga AA, Johnson TF, Graitcer SB, Hartman LK, Al-Samarrai T, Schwarz AG, et al. Severity of 2009 pandemic influenza A (H1N1) virus infection in pregnant women. Obstet Gynecol. 2010;115(4):717-26. doi: 10.1097/AOG.0b013e3181d57947, PMID: 20308830

Gajbhiye RK, Mahajan NN, Waghmare RB, Zala S, Chaaithanya IK, Kuppusamy P, et al. Clinical characteristics, outcomes, and mortality in pregnant women with COVID-19 in Maharashtra, India: Results from PregCovid registry. Indian J Med Res. 2021;153(5-6):629-36. doi: 10.4103/ijmr.ijmr_1938_21, PMID: 34596595

Martinez-Portilla RJ, Sotiriadis A, Chatzakis C, Torres-Torres J, Sosa SE, Sandoval-Mandujano K, et al. Pregnant women with SARS-CoV-2 infection are at higher risk of death and pneumonia: Propensity score matched analysis of a nationwide prospective cohort (COV19Mx). Ultrasound Obstet Gynecol. 2021;57(2):224-31. doi: 10.1002/uog.23575, PMID: 33320401

Soriano V, Ganado-Pinilla P, Sanchez-Santos M, Gómez-Gallego F, Barreiro P, de Mendoza C, et al. Main differences between the first and Second waves of COVID-19 in Madrid, Spain. Int J Infect Dis. 2021;105:374-6. doi: 10.1016/j.ijid.2021.02.115, PMID: 33684560

Published

29-06-2024

How to Cite

PS, D., and S. PK. “CLINICAL PROFILE AND PREGNANCY OUTCOMES OF COVID POSITIVE PREGNANT WOMEN IN PHASE I ANDII INFECTION – A COMPARATIVE STUDY”. Asian Journal of Pharmaceutical and Clinical Research, vol. 17, no. 7, June 2024, doi:10.22159/ajpcr.2024v17i7.51090.

Issue

Section

Original Article(s)