FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF RANITIDINE HYDROCHLORIDE BY HOLE TECHNOLOGY
Abstract
Attempts were made to prepare ranitidine fast dissolving tablets by Novel Hole technology. When these fast dissolving tablets contact with gastro intestinal fluids, the fluid will enters the hole present in the tablet and immediate breaking of the tablet is going to takes place. This fast disintegration of tablets is also influenced by the formation of new absolute area. The prepared FDTs were subjected to various pre and post formulation studies. Its disintegration and dissolution rates were compared with the control formulation (without hole).In-vitro drug release of FDTs (DH6) showed almost 100.92percent of the drug was released at 6th minute, whereas the control formulation D12, shows the 99percent drug release at 20th minute. Overall, this technique is novel and most useful for formulation into fast dissolving tablets.
Key words: Novel Fast Dissolving Tablets, Ranitidine, Hole technologyDownloads
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