EVALUATION OF MUTAGENIC EFFECT (ANTIMUTAGENIC) OF DALBERGIA LATIFOLIA ON SWISS ALBINO MICE
Abstract
Dalbergia latifolia Roxb. (Family: Fabaceae) is a traditional herb, contain latinone and    dalcriodain flavonoid having excellence medicinal value8.
Thepresentstudy wasdesignedtoevaluatetheanti-mutagenicpotentialofMethanolic extractof Dalbergia latifolia,usingmicronucleus(MN)andchromosomalaberration(CA)assay inmice bonemarrow.Theanti-mutageniceffectofDalbergia latifoliawasassessed usingcyclophosphamideMNformationandCAinmice.Theanimalswerepre-treatedwiththe MethanolicextractofDalbergia latifoliaorallyattwodosesof100, 200mg/kgbody weightforsevendays.InMNandCAtestthetwodosesprovidedprotectionwhengiven24hrs priortoasinglei.padministrationofcyclophosphamide(100mg/kgbodyweight). Theseresults demonstrate thatMethanolic extractofDalbergia latifoliahas got anti-mutagenic potential.
Keywords: Dalbergia latifolia, Methanolic extract, anti-mutagenic activityDownloads
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