DRUG UTILIZATION PATTERN IN INDOOR PATIENT OF RADIOTHERAPY DEPARTMENT AT A TERTIARY CARE HOSPITAL IN SOUTHERN RAJASTHAN

Authors

  • RAHUL DAMOR Department of Pharmacology, RNT Medical College, Udaipur, Rajasthan, India
  • MEENA ATRAY Department of Pharmacology, RNT Medical College, Udaipur, Rajasthan, India
  • RAMKIRAN NV Department of Pharmacology, RNT Medical College, Udaipur, Rajasthan, India.
  • CHETAN JANI Department of Pharmacology, RNT Medical College, Udaipur, Rajasthan, India.
  • HARSH K BRAHMBHATT Department of Pharmacology, RNT Medical College, Udaipur, Rajasthan, India
  • ARVIND SINGH TANWAR Department of Pharmacology, RNT Medical College, Udaipur, Rajasthan, India

DOI:

https://doi.org/10.22159/ajpcr.2024v17i10.52526

Keywords:

Drug utilization, Anticancer drugs, Prescribing pattern

Abstract

Objective: The study was planned to evaluate on drug utilization pattern of drug use in the indoor of radiotherapy department, using the World Health Organization recommended core drug use indicators, to compare the cost of drug used and to provide feedback to the concerned department to improve rational prescribing.

Methods: Four hundred and five newly diagnosed cases of cancer with age more than 18 of both genders were included in the study. The demographic data, diagnosis, group of anticancer drugs, individual anticancer drug, combinations of anticancer drugs, and cost of drug reactions were recorded and analyzed statistically, using descriptive study statistics.

Results: Cervical cancer (19.51%) was the most frequently diagnosed cancer, followed by lung cancer (17.04%). Platinum compounds (76.30%) were maximum utilized group of drugs. Carboplatin was the most commonly prescribed drug (53.09). Average number of drugs prescribed per prescription was 8.77. Carboplatin + Paclitaxel combination was the most commonly prescribed combination. Pantoprazole was maximally used adjuvant drug.

Conclusion: About 100% of drugs were prescribed by generic name and 86.27% of drugs were prescribed from National List of Essential Medicines of India, 2022 indicates rational prescribing. The cost of anticancer drugs was much less in comparison to other studies.

Downloads

Download data is not yet available.

References

Bray F, Laversanne M, Weiderpass E, Soerjomataram I. The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer. 2021;127(16):3029-30. doi: 10.1002/cncr.33587

Mathur P, Sathishkumar K, Chaturvedi M, Das P, Sudarshan KL, Santhappan S, et al. Cancer Statistics, 2020: Report from national cancer registry programme, India. JCO Glob Oncol. 2020;6:1063-75.

Haskell CM. Introduction. Cancer Treatment. 4th ed. Philadelphia, PA, USA: WB Saunders; 1995. p. 3-9.

Rang HP, Dale MM, Ritter JM, Flower RJ. Rang and Dale’s Pharmacology. Philadelphia, PA: Elsevier Publisher; 2007. p. 718-38.

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90.

Takiar R, Nadavil D, Nandakumar A. Projections of number of cancer cases in India (2010-2020) by cancer groups. Asian Pac J Cancer Prev. 2010;11:1045-9.

Malhotra V, Perry MC. Classical chemotherapy: Mechanisms, toxicities and the therapeutic window. Cancer Biol Ther. 2003;2:S2-4.

World Health Organization. WHO: Introduction to Drug Utilization Research. WHO International Working Group for Drug Statistics Methodology, WHO Collaborating Centre for Drug Statistics Methodology, WHO Collaborating Centre for Drug Utilization Research and Clinical Pharmacological Services. Geneva: WHO; 2003. Available from: https://www.whocc.no/filearchive/publications/drug_ utilization_research.pdf

Sood P, Bindra S. Modified Kuppuswamy socioeconomic scale: 2022 update of India. Int J Community Med Public Health. 2022;9:3841-4.

National List of Essential Medicines (NLEM); 2022. Available from: https://www.nhp.gov.in/sites/default/files/2022_national_list_of_ essential_medicines.pdf

Aggarwal M, Chawla S, Singh K, Rana P. Evaluation of anticancer drug utilization and monitoring of adverse drug reaction in the indoor patients receiving cancer chemotherapy in a tertiary care hospital in New Delhi. J Basic Clin Pharma. 2018;9:118-24.

Mandal A, Gangopadhyay T, Mandal S. Drug utilization study in a radiotherapy unit of a tertiary care teaching hospital in rural West Bengal, India. Asian J Pharm Clin Res. 2022;15(11):126-30.

Kamlekar SK, Agarwal A, Latha PA, Gupta S. Evaluation of drug utilization pattern of anticancer drugs in oncology department of a tertiary care teaching hospital of Southern Rajasthan. Natl J Physiol Pharm Pharmacol. 2020;10(1):15-20.

Chandan NG, Ranganathan T, Nagabushan H. Study of drug utilization pattern in the department of radiotherapy in a tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2019;8:945-9.

Mugada V, Paruchuri A, Munagala M. Drug utilization evaluation of anticancer drugs in a tertiary care teaching hospital: A descriptive observational study. J Appl Pharm Sci. 2016;6:98-101. doi: 10.7324/ japs.2016.601013

Bepari A, Sakre N, Rahman I, Niazi SK, Dervesh AM. The assessment of drug utilization study of anticancer drugs using WHO prescribing indicators in a government tertiary care hospital of the Hyderabad - Karnataka region of India. Open Access Maced J Med Sci. 2019;7(7):1203-8. doi: 10.3889/oamjms.2019.249

Kumar BS, Maria S, Shejila CH, Udaykumar P. Drug utilization review and cost analysis of anticancer drugs used in a tertiary care teaching hospital. Indian J Pharm Sci. 2018;80(4):686-693. doi: 10.4172/ pharmaceutical-sciences.1000408

Dutta K, Dutta S, Mishra KC, Hrangkhol NT, Chandan NG. Drug utilisation pattern and cost analysis of anticancer drugs in a cancer care hospital, Diphu Medical College and Hospital. Int J Toxicol Pharmacol Res. 2023;13(10):107-12.

Published

07-10-2024

How to Cite

RAHUL DAMOR, MEENA ATRAY, RAMKIRAN NV, CHETAN JANI, HARSH K BRAHMBHATT, and ARVIND SINGH TANWAR. “DRUG UTILIZATION PATTERN IN INDOOR PATIENT OF RADIOTHERAPY DEPARTMENT AT A TERTIARY CARE HOSPITAL IN SOUTHERN RAJASTHAN”. Asian Journal of Pharmaceutical and Clinical Research, vol. 17, no. 10, Oct. 2024, pp. 46-49, doi:10.22159/ajpcr.2024v17i10.52526.

Issue

Section

Original Article(s)