USAGE OF SUGAR ESTER IN THE PREPARATION OF AVOCADO OIL NANOEMULSION
Objectives: Due to the high dynamics of pharmaceutical products markets, developments of new products using latest innovative technology are
becoming a norm of many pharmaceutical companies. Nanoscale materials such as nanoemulsion (NE) offer advantages such as the controllable
droplet size, long-term stability, and power solubilization ability. It is beneficial in various delivery systems either for transdermal, ocular, nasal,
vaginal, and parenteral drug delivery. The objective of the study was to prepare avocado oil NE using different surfactants to find the most suitable
nanosized droplets, as avocado oil offers a variety of purported nutritional and medicinal benefits.
Methods: Sucrose esters, glycerol, and avocado oil with different ratio were used to produce pre-NE by phase inversion technique then pre-NE
were self-emulsified with water to produce NE. The influence of the sucrose esters surfactants on the NE formulations were determined using three
different types of sucrose esters surfactant (laureate, oleate, and palmitate). Stability study was conducted for NE at different temperatures (4Â°C, 25Â°C,
and 40Â°C) for 6 months.
Results: The NE contained sucrose laureate produced best nanosized formulations compared to other oleate and palmitate, with optimum droplet
size 106 Â± 1.70 nm, size distribution 0.156 Â± 0.01, and zeta potential âˆ’30.4 Â± 0.70. The NE formulations were very stable at 4Â°C compared to 25Â°C and
40Â°C while at 25Â°C NE showed moderate stability, but it was unstable at 40Â°C.
Conclusion: Sucrose laureate was able to produce NE with phase inversion and self-emulsification techniques and the ideal storage condition for NE is 4Â°C.
Keywords: Avocado oil, Nanoemulsions, Self-nanoemulsification, Phase inversion technique, Sucrose ester, Stability.
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