STUDY OF RENAL FUNCTION TESTS IN THYROID DISORDER PATIENTS
DOI:
https://doi.org/10.22159/ajpcr.2024v17i12.52950Keywords:
Creatinine, Urea, Glomerular filtration rate, HypothyroidismAbstract
Objective: To analyse serum creatine, urea, fT3, fT4 and TSH among thyroid disorder patients.
Method: 75 thyroid disorder patients were included in the study. Serum creatinine and blood urea were determined by the colorimeteric method using an autoanalyzer c311. Thyroid Profile-fT3, fT4, and TSH were estimated by chemiluminescence immunoassay. Serum creatinine and blood urea were found to be raised among hypothyroidisms.
Results: The mean fT3=2.09, mean fT4= 0.88 and mean TSH=17.82μIU/ml, mean urea=72.32 mg/dl and mean creatinine=2.4 mg/dl. The highest creatinine value was 12 mg/dl and highest urea value among the hypothyroidism patient was found to be 180.4 mg/dl.
Conclusion: Assessment of hypothyroidism and its effect on kidney will be helpful in early diagnosis and management of the patients
Downloads
References
Bahn Chair RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, et al. Hyperthyroidism and other causes of thyrotoxicosis: Management guidelines of the American thyroid association and American association of clinical endocrinologists. Thyroid. 2011 Apr;21(6):593-646. doi: 10.1089/thy.2010.0417, PMID 21510801
Mariani LH, Berns JS. The renal manifestations of thyroid disease. J Am Soc Nephrol. 2012 Jan;23(1):22-6. doi: 10.1681/ASN.2010070766, PMID 22021708
Avasthi G, Malhotra S, Narang AP, Sengupta S. Study of thyroid function in patients of chronic renal failure. Indian J Nephrol. 2001 Jan;11(4):165-70. doi: 10.4103/0971-4065.34830
Iglesias P, Díez JJ. Thyroid dysfunction and kidney disease. Eur J Endocrinol. 2009 Apr;160(4):503-15. doi: 10.1530/EJE-08-0837, PMID 19095779
Van Hoek I, Daminet S. Interactions between thyroid and kidney function in pathological conditions of these organ systems: A review. Gen Comp Endocrinol. 2009 Feb;160(3):205-215. doi: 10.1016/j. ygcen.2008.12.008, PMID 19133263
Iglesias P, Bajo MA, Selgas R, Díez JJ. Thyroid dysfunction and kidney disease: an update. Rev Endocr Metab Disord. 2017 Mar;18(1):131-44. doi: 10.1007/s11154-016-9395-7, PMID 27864708.
Stojanoski S, Pop Gjorceva D, Gruev T, Ristevska-Miceva S, Ristevska N. Impact of thyroid dysfunction on serum cystatin C, serum creatinine and glomerular filtration rate. Maced J Med Sci. 2011 Mar;4(1):25-30.
Osman AI, Morsi AN. Correlation between renal function tests and thyroid hormones in Sudanese patients with hypo-and hyperthyroidism. Int J Sci Res. 2017 May;6(5):1239-42.
Saini V, Yadav A, Arora MK, Arora S, Singh R, Bhattacharjee J. Correlation of creatinine with TSH levels in overt hypothyroidism-a requirement for monitoring of renal function in hypothyroid patients? Clin Biochem. 2012 Feb;45(3):212-4. doi: 10.1016/j. clinbiochem.2011.10.012, PMID 22061337
Montenegro J, González O, Saracho R, Aguirre R, González O, Martínez I. Changes in renal function in primary hypothyroidism. Am J Kidney Dis. 1996 Feb;27(2):195-198. doi: 10.1016/s0272- 6386(96)90539-9, PMID 8659492
Ghosh M, Bandyopadhyay K, Sinha B, Biswas MK, Biswas DM. Evaluation of kidney function in hypothyroid subjects and its correlation with fT4 and TSH level. Int J Acad Med Pharm. 2023 Jun;5(3):1928-1931.
Attaullah S, Haq BS and Ahmed Z. Correlation of thyroid dysfunction with serum creatinine. Int J Multidiscip Res Dev. 2015 Aug;2(8):89-90.
Yang Z, Duan P, Li W, Nie R, Lou X, Wang L, et al. The correlation between thyroid hormone levels and the kidney disease progression risk in patients with type 2 diabetes. Diabetes Metab Syndr Obes. 2022 Jan;15:59-67. doi: 10.2147/DMSO.S347862, PMID 35023940.
Published
How to Cite
Issue
Section
Copyright (c) 2024 VANITA SHARMA, USHYENDER SHARMA, BHARTI KAWATRA, J P BHARTIYA, H K WALIA
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
