ANTIPYRETIC ACTIVITY OF ANNONA PLANTS LEAVES ON BREWER'S YEAST INDUCED FEBRILE RATS
Abstract
Objective: To evaluate and compare the in vivo antipyretic activity of the methanolic extracts of selected three Annona plant leaves.
Methods: The acute oral toxicity determined by OECD class method and the in vivo antipyretic activity was determined by brewer's yeast induced
pyrexia method.
Results: The results showed that the methanolic extract of leaves of Annona plants are non-toxic and possessed significant antipyretic effect which
may be attributed to the presence of flavonoids and saponins in the extracts.
Conclusion: This study provides evidences for the antipyretic activity of Annona squamosa, Annona reticulata and Annona muricata possess antipyretic
activity at the tested doses 100 and 200 mg/kg body weight without any side effects, which could partly contribute to its ethno medical use.
Keywords: Annona squamosa L, Annona reticulata L, Annona muricata L, Antipyretic activity, Brewer's yeast.
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