FORMULATION AND EVALUATION OF OPHTHALMIC GEL BASED ON DRUG-POLYMER-POLYMER TERNARY INTERACTION
Abstract
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Objective: The objective was to enhance the amount of active substance reaching the target tissue or exerting a local effect in the cul-de-sac, the
approach we use is the application of in-situ gelling systems or phase transition systems, which are instilled in a liquid form and shift to a gel or solid
phase in the cul-de-sac. The present study will focus on the development of formulation of ophthalmic gels. The polymer physicochemical properties
were studied for the improvement in gel characteristics.
Methods: The formulations were varied by the amount of the anionic and cationic polymer concentration. The 10 and 20-fold excess anionic polymer
were used. The 10 and 20-fold excess anionic polymer were used. Further cationic polymers were utilized to see any ternary interaction between
drug and polymers.
Results: From the present study it could be shown that most of the formulations were isotropic and could be clearly separated from the anisotropic
ones which were situated at the cationic side of the phase diagram only as well as at 10% polyvinyl alcohol. Furthermore, excess 20HA, 10PAA, and
20PAA as well as HCS (HCS/20PAA) contributes to improve drug release control.
Conclusion: The above formulation of were found to be quite stable and useful in the novel format of sol-gel transformations. Further, the physical
characteristics gels show better tolerability with anionic and cationic polymer.
Keywords: Cationic, Anionic, Poloxamer, Sol-gel.
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